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diabetes-endocrinology

Houston, Texas

Anatomy instruction at Baylor College of Medicine
Medicine/Endocrinology
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Wenhao Chen, Ph.D.

Wenhao Chen, Ph.D.Assistant Professor of Medicine


One Baylor Plaza (MS: BCM185)
ABBR, Room R608
Houston, TX 77030
Tel: 713-798-1698
Fax: 713-798-4575
E-mail: wenhaoc@bcm.edu




Education

  • Ph.D.: University of Toronto, Ontario, Canada, 2001-2006
  • M.D.: Shanghai Second Medical University, Shanghai China, 1989-1994

Research Interests

  • Define the molecular mechanisms of T-cell tolerance
  • Design immune intervention therapies for type 1 diabetes and transplantation
  • Develop beta cell replacement therapies for type 1 diabetes

Select Publications

Miyahara Y, Khattar M, Schroder P, Mierzejewska B, Deng R, Han R, Hancock WW, Chen W*,Stepkowski S*. An anti-TCRβ mAb induces longterm allograft survival as well as prevents and reverses the onset of type-1 diabetes. Am J Transplant. 2012; Epub ahead of print; PMID: 22420295. *corresponding authors

Li J, Chen G, Ye P, Wang S, Zhang K, Chen W, Stepkowski SM, Li J, Zhong S, Xia J. CCR5 blockade in combination with cyclosporine increased cardiac graft survival and generated alternatively activated macrophages in primates. J Immunol. 2011; 186:3753. PMID: 2130729

Xie A, Wang S, Zhang K, Wang G, Ye P, Li J, Chen W, Xia J. Treatment with Interleukin-12/23p40 Antibody Attenuates Acute Cardiac Allograft Rejection. Transplantation. 2011; 91:27-34. PMID: 21452409

Wang G, Khattar M, Guo Z, Miyahara Y, Linkes SP, Sun Z, He X, Stepkowski SM, Chen W. IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4+CD25+ regulatory T cell which jointly restrain CD4+CD25- cell activation. Immunol Lett. 2010; 132:61. PMCID: PMC2922908

Wang G, Miyahara Y, Guo Z, Khattar M, Stepkowski S, Chen W. "Default" generation of neonatal regulatory T cells. J Immunol. 2010; 185:71. PMID: 20498359

Guo Z, Wang G, Miyahara Y, Khattar M, Linkes SP, Wang C, Xia J, Pan Y, Chen W, He X, Stepkowski SM. IL-7, but not thymic stromal lymphopoietin (TSLP), during priming enhances the generation of memory CD4+ T cells. Immunol Lett. 2010; 128:116. PMID: 20064560

Khattar M, Chen W, Stepkowski SM. Expanding and converting regulatory T cells: a horizon for immunotherapy. Arch Immunol Ther Exp (Warsz). 2009; 57:199. PMID: 19479206

Miyahara Y, Odunsi K, Chen W, Peng G, Matsuzaki J, and Wang RF. Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer. Proc Natl Acad Sci U S A. 2008; 105:15505. PMCID: PMC2563129

Stepkowski SM, Chen W, Ross JA, Nagy ZS, Kirken RA. STAT3: an important regulator of multiple cytokine functions. Transplantation. 2008; 85:1372-7. PMID: 18497672

Stepkowski SM, Chen W. Functional quartet of CD4+ T cells: a concert by multiple cytokines. Expert Reviews of Clinical Immunology. 2008; 4:5-7. PMID: 20477580

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