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diabetes-endocrinology

Houston, Texas

Anatomy instruction at Baylor College of Medicine
Medicine/Endocrinology
not shown on screen

Vijay K. Yechoor, M.D.

Assistant Professor of Medicine and
Molecular & Cellular Biology

One Baylor Plaza (MS: BCM185)
ABBR, Room 612
Houston, TX 77030
Tel: 713-798-4146 or 3879 (lab)
Fax: 713-798-8764
Email: vyechoor@bcm.edu

Education

  • M.B.B.S., All India Institute of Medical Sciences, New Delhi, India, 1991
  • Internship, Michael Reese Medical Center, University of Illinois, Chicago, IL, 1992-1993
  • Residency, Internal Medicine, Baylor College of Medicine, Houston, TX, 1993-1995
  • Clinical and Research Fellowship, Diabetes, Endocrinology & Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, 1996-7 & 2000-2002
  • Molecular Medicine Fellowship: Baylor College of Medicine, Houston, TX, 2003-2004

Research Interests

  • Islet biology
  • Insulin resistance, type 2 diabetes and the metabolic syndrome
  • Autoimmune type 1 diabetes
  • Somatic gene therapy and other molecular therapies for the treatment of diabetes
  • Circadian pathophysiology

Publications

Peer-reviewed Journals

  • Lee J, Kim MS, Li R, Liu VY, Fu L, Moore DD, Ma K, Yechoor VK. Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells. Islets. 2011 Nov 1;3(6):381-8. PMID: 22045262
  • Park YJ, Kim SC, Kim J, Anakk S, Lee JM, Tseng HT, Yechoor V, Park J, Choi JS, Jang HC, Lee KU, Novak CM, Moore DD, Lee YK.Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner. J Lipid Res. 2011 Dec;52(12):2234-44. PMCID: PMC3220290
  • Yang Y, Chang BH, Yechoor V, Chen W, Li L, Tsai MJ, Chan L. The Krüppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice. Diabetologia. 2011 Oct; 54(10):2595-605. PMCID: PMC3184604
  • Yechoor V, Liu V, Paul A, Lee J, Buras E, Ozer K, Samson S, Chan L. Gene therapy with neurogenin 3 and betacellulin reverses major metabolic problems in insulin-deficient diabetic mice. Endocrinology. 2009 Nov;150(11):4863-73. PMCID: PMC2775983
  • Chen W, Yechoor VK, Chang BH, Li MV, March KL, Chan L. The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation. Endocrinology. 2009 Oct;150(10):4552-61. PMCID: PMC2754678
  • Yechoor V, Liu V, Espiritu C, Paul A, Oka K, Kojima H, Chan L. Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev Cell. 2009 Mar;16(3):358-73. PMCID: PMC2676438
  • Samson SL, Gonzalez EV, Yechoor V, Bajaj M, Oka K, Chan L. Gene therapy for diabetes: metabolic effects of helper-dependent adenoviral exendin 4 expression in a diet-induced obesity mouse model. Mol Ther. 2008 Nov;16(11):1805-12. PMCID: PMC2582376
  • Paul A, Chang BH, Li L, Yechoor VK, Chan L. Deficiency of adipose differentiation-related protein impairs foam cell formation and protects against atherosclerosis. Circ Res. 2008 Jun 20;102(12):1492-501. PMCID: PMC2773502
  • Paul A, Yechoor V, Raja R, Li L, Chan L. Microarray gene profiling of laser-captured cells: a new tool to study atherosclerosis in mice. Atherosclerosis. 2008 Oct;200(2):257-63. PMCID: PMC26137

Book Chapters

  • Samson SL, Yechoor V, Chan L (2008) Molecular Therapy for Type 1 and Type 2 Diabetes. In: Gene and Cell Therapy. Nancy Smyth Templeton (ed). Marcel Dekkar, New York, USA.
  • Yechoor V. Cushing’s Syndrome. In: Conns Current Therapy 2010. Edward T. Bope, Robert E. Rakel, Rick Kellerman (eds). Elsevier Inc.

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