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Houston, Texas

Anatomy instruction at Baylor College of Medicine
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Mandeep Bajaj, M.D.

Professor of Medicine and
Molecular & Cellular Biology

1709 Dryden, Suite 6.41 (MS: BCM620)
Houston, TX 77030
Tel: 713-798-1712
Fax: 713-798-4593


  • M.B.B.S.: All India Institute of Medical Sciences, New Delhi, India -1989
  • Residency: Internal Medicine, Albert Einstein College of Medicine, Bronx , NY - 1994
  • Residency: Internal Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India - 1991
  • Clinical and Research Fellowship: Endocrinology/Diabetes/Metabolism, Harvard Medical School/Beth Israel Deaconess Hospital, Joslin Diabetes Center and Brigham and Womens Hospital Joint Longwood Area Program, Boston, MA - 1997

Research Interests

  • Type 2 diabetes and insulin resistance –pathophysiology
  • Effect of FFA on hepatic and peripheral (muscle) insulin resistance and skeletal muscle insulin signaling
  • Vascular and inflammatory effects of adipocytokines
  • Molecular mechanisms of adiponectin action
  • Relationship between hepatic/intramyocellular fat content and insulin action

Recent Publications

  • Samson SL, Sathyanarayana P, Jogi M, Gonzalez EV, Gutierrez A, Krishnamurthy R, Muthupillai R, Chan L, Bajaj M. Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity & in a drandomised controlled trial. Diabetologia. 2011 Dec;54(12):3093-100. PMID: 21956711
  • Sathyanarayana P, Jogi M, Muthupillai R, Krishnamurthy R, Samson SL, Bajaj M. Effects of combined exenatide & pioglitazone therapy on hepatic fat content in type 2 diabetes. Obesity (Silver Spring). 2011 Dec;19(12):2310-5. PMID: 21660077
  • Choudhary S, Sinha S, Zhao Y, Banerjee S, Sathyanarayana P, Shahani S, Sherman V, Tilton RG, Bajaj M. NF-kappaB-inducing kinase (NIK) mediates skeletal muscle insulin resistance: blockade by adiponectin. Endocrinology. 2011 Oct;152(10):3622-7 PMID: 21846802
  • Holmes RM, Yi Z, De Filippis E, Berria R, Shahani S, Sathyanarayana P, Sherman V, Fujiwara K, Meyer C, Christ-Roberts C, Hwang H, Finlayson J, Dong LQ, Mandarino LJ, Bajaj M. Increased abundance of the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1) in patients with obesity and type 2 diabetes: evidence for altered adiponectin signalling. Diabetologia. 2011 Aug;54(8):2122-31. PMID: 21562756
  • Bajaj M, Baig R, Suraamornkul S, Hardies LJ, Coletta DK, Cline GW, Monroy A, Koul S, Sriwijitkamol A, Musi N, Shulman GI, DeFronzo RA. Effects of pioglitazone on intramyocellular fat metabolism in patients with type 2 diabetes. J Clin Endocrinol Metab. 2010 Apr;95(4):1916-23. Epub 2010 Feb 15. PMCID: PMC2853997
  • Suraamornkul S, Kwancharoen R, Ovartlarnporn M, Rawdaree P, Bajaj M. Insulin clamp-derived measurements of insulin sensitivity and insulin secretion in lean and obese asian type 2 diabetic patients. Metab Syndr Relat Disord. 2010 Apr;8(2):113-8. PMID: 20059360
  • Kashyap SR, Roman LJ, Mandarino L, DeFronzo R, Bajaj M. Hypoadiponectinemia is closely associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects. Metab Syndr Relat Disord. 2010 Oct;8(5):459-63. PMCID: PMC3125557
  • Yi Z, Bowen BP, Hwang H, Jenkinson CP, Coletta DK, Lefort N, Bajaj M, Kashyap S, Berria R, De Filippis EA, Mandarino LJ.Global relationship between the proteome and transcriptome of human skeletal muscle. Proteome Res. 2008 Aug;7(8):3230-41. PMID: 18613714
  • Barseghian A, Gawande D, Bajaj M.Adiponectin and vulnerable atherosclerotic plaques. J Am Coll Cardiol. 2011 Feb 15;57(7):761-70. PMID: 21562756
  • Samson SL, Gonzalez EV, Yechoor V, Bajaj M, Oka K, Chan L. Gene therapy for diabetes: metabolic effects of helper-dependent adenoviral exendin 4 expression in a diet-induced obesity mouse model. Mol Ther. 2008 Nov;16(11):1805-12 . PMCID: PMC2582376

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