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Section of Atherosclerosis

Houston, Texas

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Section of Atherosclerosis and Vascular Medicine
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John W. Gaubatz, M.S.

Photo John Gaubatz, M.S.

Position:

Instructor of Medicine

Contact Information:

Phone: 713-798-4081
Fax: 713-798-4121
E-mail: gaubatz@bcm.edu

Basic and Clinical Research Interests:

My research interests broadly include lipoprotein metabolism related to structure/function relationships. This has focused on the identification and characterization of dense, electronegative low-density lipoprotein (LDL) subfractions in human normolipidemic plasma. Non-esterified fatty acids (NEFA) were identified as one of the primary components directly responsible for the increased electronegative charge. Lipoprotein-associated phospholipase A2 (Lp-PLA2) was highly enriched in the small, dense LDL subfractions. Lp-PLA2 has been implicated in inflammation and serves as a marker of atherosclerosis. Further studies on the mechanism of the association and binding of Lp-PLA2 to these dense, electronegative LDL subfractions and the influence of such factors as NEFA content, particle size, and electronegativity are of interest to our laboratory. Preliminary studies have also demonstrated marked differences in the correlation of mass and activity of Lp-PLA2 bound to these subfractions. The detailed quantitation of Lp-PLA2 mass and activity in subfractions of LDL and HDL and their correlation is also of interest in future studies. Most recently, we have studied the relationship between circulating levels of matrix metalloproteinases and TIMP-1 with carotid artery characteristics as measured by MRI in the ARIC cohort.

Selected Publications:

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