Patrick Barth, Ph.D.
Department of Pharmacology
Department of Biochemistry and Molecular Biology
Lab Website: Barth Lab
- Ph.D., University of Paris XI, France
- Postdoctoral, University of California, Berkeley and University of Washington
Exploring and reprogramming the mechanisms of signal transduction across biological membranes
Our long-term goal is to understand how ligand/ membrane receptor/ downstream effector systems transmit specific signals across biological membranes and to exploit this knowledge to reengineer signaling pathways.
We address these objectives using a combination of computational and experimental approaches to model, design and reprogram ligand/ receptor/ effector interaction networks. Our long-term goal is to deconstruct the complex function and quantitatively describe the basic principles underlying these signaling networks.
We are affiliated with the Department of Pharmacology, the Verna and Marrs McLean Department of Biochemistry and Molecular Biology, the Program in Structural & Computational Biology and Molecular Biophysics, and the Duncan Cancer Center.
Selected Publications (* these authors contributed equally)
- Chen, K.M., Fuguo, Z., Fryszczyn, B.G., Barth, P. Naturally-evolved G protein-coupled receptors adopt metastable conformations (2012) Proc Natl Acad Sci U S A (in press)
- Kufareva, I. et al. Status of GPCR modeling and docking as reflected by community wide GPCR Dock 2010 assessment. (2011) Structure 19(8), 1108-26.
- Barth, P. Prediction of three-dimensional transmembrane helical protein structures. (2010), in Structural Bioinformatics of Membrane Proteins, Springer Editions, 231-49.
- Michino, M., et al. Community-wide assessment of GPCR structure modelling and ligand docking : GPCR Dock 2008 (2009) Nature Review Drug Discovery 8(6), 455-63.
- Barth, P.*, Zhu, J.*, Luo, B.H.*, Schonbrun, J., Baker, D., Springer, T. The structure of a receptor with two associating transmembrane domains on the cell surface : integrin aIIbb3. (2009) Molecular Cell 34(2), 234-49.
- Barth, P.*, Wallner, B.*, Baker, D. Prediction of membrane protein structures with complex topologies using limited constraints. (2009) Proc Natl Acad Sci U S A (Track II) 106(5), 1409-14.
- Barth, P., Schoeffler, A., Alber, T. Targeting metatstable coiled-coil domains by computational design (2008) Journal of the American Chemical Society, 130(36), 12038-44.
- Barth, P. Modulating membrane protein stability and association by design (2007) Current Opinion in Structural Biology 17(4), 460-6.
- Pathak, M.*, Yarov-Yarovoy, V.*, Agarwal, G., Roux, B., Barth, P., Kohout, S., Tombola, F., Isacoff , E.U. Closing in on the resting state of the shaker K+ channel (2007) Neuron 56(1), 124-40.
- Barth, P., Schonbrun, J., Baker D. Toward high-resolution prediction and design of transmembrane helical protein structures (2007) Proc Natl Acad Sci U S A (Track II) 104(40), 15682-7.