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Department of Biochemistry and Molecular Biology

Houston, Texas

Images from biochemistry and molecular biology research
Verna and Marrs McLean Department of Biochemistry and Molecular Biology
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Steven J. Ludtke, Ph.D.

Steven J. Ludtke, Ph.D.

Department of Biochemistry and Molecular Biology

Co-Director, National Center for Macromolecular Imaging

National Center for Macromolecular Imaging


  • B.S., Physics, Caltech (1990)
  • M.A., Physics, Rice University (1993)
  • Ph.D., Physics, Rice University (1996)


  • Burton Medal by the Microscopy Society of America, 2008

Research Interests

My work primarily focuses on electron cryomicroscopy and its application to important problems in structural biology. I am interested in a wide range of techniques in this field, including: single particle reconstruction, tomography and single particle tomography. Single particle reconstruction is my primary focus, and my major contribution to the field is the development of EMAN, a software suite for processing images of individual molecules and producing 3D structures at subnanometer resolution. In addition to methods development we also apply these techniques to a wide range of important biological targets, including chaperonins, large ion channels, LDL/HDL and a wide range of other targets.

My broader interests include all aspects of scientific image processing, development of ontology-based scientific databases, Grid (and other massively parallel) computational techniques, scientific visualization and animation and various aspects of the protein folding problem.

Selected Publications

View more publications by Dr. Ludtke.

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