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Department of Biochemistry and Molecular Biology

Houston, Texas

Images from biochemistry and molecular biology research
Verna and Marrs McLean Department of Biochemistry and Molecular Biology
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Ido Golding, Ph.D.

Ido Golding, Ph.D.

Associate Professor
Department of Biochemistry and Molecular Biology

golding@bcm.edu

Lab Web Site: Golding Lab

Education

  • B.Sc., Physics, Technion, Israel Institute of Technology, 1991
  • M.Sc., Physics, Tel Aviv University, Israel, 1997
  • Ph.D., Physics, Tel Aviv University, Israel, 2001
  • Postdoctoral, Molecular Biology, Princeton University, 2006

Using Physical Principles to Understand Living Systems

In my lab, we examine the way living cells process information from their environment and make decisions based on that information. Our aim is to form a quantitative narrative for the dynamics of cellular decision-making and unveil simple principles that underlie such processes. As a model system, we use the bacterium E. coli and its virus, phage lambda. We study their complex interaction at the level of individual events in space and time.

Work in the lab involves a set of skills broader than what is generally mastered within a single discipline, including the techniques of microbiology and molecular genetics; live single-cell microscopy for making dynamic measurements; and data analysis using the engineer's toolbox of signal- and image processing; all accompanied by the theoretical tools of dynamical systems theory, stochastic processes, non-equilibrium phenomena and more. The practice of modern in vivo biology, combined with the intellectual effort of a quantitative approach, will contribute significantly to a young scientist's training experience, better preparing them for the future world of "Systems Biology".

Selected Publications

  • Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang A, Solimini N, Bernardi RJ, Yu B, Hsu T, Golding I, Luo J, Osborne CK, Creighton CJ, Hilsenbeck SG, Schiff R, Shaw CA, Elledge SJ, Westbrook TF. A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science 335(6066):348-53 (2012).
  • Min L, Mears P, Golding I, Chemla YR. Chemotactic adaptation kinetics of individual Escherichia coli cells. Proc. Natl. Acad. Sci. USA 109 (25), 9869-74 (2012).
  • Golding I. Decision making in living cells: lessons from a simple system. Annu. Rev. Biophys. 40:63-80 (2011).
  • So LH, Ghosh A, Zong C, Sepulveda LA, Segev R, Golding I. General properties of the transcriptional time series in Escherichia coli. Nature Genetics 43:554–60 (2011).
  • Zong C, So L, Sepulveda L, Skinner SO, Golding I. Lysogen stability is determined by the frequency of activity bursts from the fate-determining gene. Molecular Systems Biology 6:440 (2010).
  • Zeng L, Skinner SO, Zong C, Sippy J, Feiss M, Golding I. Decision making at a subcellular level determines the outcome of bacteriophage infection. Cell 141 (4) 682-91 (2010).
  • Min TL, Mears PJ, Chubiz LM, Rao CV, Golding I, Chemla YR. High-resolution, long-term characterization of bacterial motility using optical tweezers. Nature Methods 6(11):831-5 (2009).
  • Golding I, Cox EC. Physical nature of bacterial cytoplasm. Phys. Rev. Lett. 96, 098102 (2006).
  • Golding I, Paulsson J, Zawilski SM, Cox EC. Real-time kinetics of gene activity in individual bacteria. Cell 123 (6) 1025-36 (2005).
  • Golding I, Cox EC. RNA dynamics in live E. coli cells. Proc. Natl. Acad. Sci. USA 101 (31) 11310-15 (2004).

computer-generated lysozyme model

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