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Golding Lab

Houston, Texas

DNA (purple) and mRNA (red) labeled in individual E. coli cells. (Golding Lab)
Golding Lab
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Publications

P.J. Mears, S. Koirala, C.V. Rao, I. Golding, Y.R. Chemla, "Escherichia coli swimming is robust against variations in flagellar number." eLife 2014 Feb 11;3:e01916. [PubMed]

L. Figard, H. Xu, H.G. Garcia, I. Golding, A.M. Sokac, "The Plasma Membrane Flattens Out to Fuel Cell-Surface Growth during Drosophila Cellularization." Dev Cell. 2013 Dec 23;27(6):648-55 [PubMed]

A. Sanchez, I. Golding, "Genetic determinants and cellular constraints in noisy gene expression." Science 2013 Dec 6;342(6163):1188-93 [PubMed] See also: Science Podcast

L. Zheng, L.A. Sepúlveda, R.C. Lua, O. Lichtarge, I. Golding, A.M. Sokac, "The Maternal-to-Zygotic Transition Targets Actin to Promote Robustness during Morphogenesis." PLoS Genet., 9(11): e1003901. [PubMed]

S.O. Skinner, L.A. Sepúlveda, H. Xu, I. Golding, "Measuring mRNA copy number in individual Escherichia coli cells using single-molecule fluorescent in situ hybridization." Nat Protoc. 2013 Jun;8(6):1100-13. [PubMed] See also: Human Frontier Science Program

T. L. Min, P. J. Mears, I. Golding, Y.R. Chemla, "Chemotactic adaptation kinetics of individual Escherichia coli cells." Proc. Natl. Acad. Sci. USA, 2012 Jun 19;109(25):9869-74. Epub 2012 Jun 7. [PubMed]

J.D. Kessler, K.T. Kahle, T. Sun, K.L. Meerbrey, M.R. Schlabach, E.M. Schmitt, S.O. Skinner, Q. Xu, M.Z. Li, Z.C. Hartman, M. Rao, P. Yu, R. Dominguez-Vidana, A.C. Liang, N.L. Solimini, R.J. Bernardi, B. Yu, T. Hsu, I. Golding, J. Luo, C.K. Osborne, C.J. Creighton, S.G. Hilsenbeck, R. Schiff, C.A. Shaw, S.J. Elledge, T.F. Westbrook, "A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis.", Science, 2012 Jan 20;335(6066):348-53 [PubMed]

L. Zeng, I. Golding, "Following Cell-fate in E. coli After Infection by Phage Lambda", J Vis Exp, 2011 Oct 14;(56) [PubMed]

R. Zhang, E. Rothenberg, G. Fruhwirth, P. D. Simonson, F. Ye, I. Golding, T. Ng, W. Lopes, P. R. Selvin, "Two-photon 3D FIONA of individual quantum dots in an anqueous environment." Nano Lett. 2011 Oct 12;11(10):4074-8 [PubMed]

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, "Optical measurement of cycle-dependent cell growth." Proc. Natl. Acad. Sci. USA, 2011 Aug 9;108(32):13124-9 [PubMed] See also: UIUC press

E. Rothenberg. L. A. Sepúlveda, S. O. Skinner, L. Zeng, P. R. Selvin, and I. Golding, "Single-Virus Tracking Reveals a Spatial Receptor-Dependent Search Mechanism." Biophys. J., 2011 Jun 22;100(12):2875-82 [PubMed]

I. Golding, "Decision Making in Living Cells: Lessons from a Simple System" Annual Review of Biophysics, 2011 Jun 9;40:63-80 [PubMed]

L.-h. So, A. Ghosh, C. Zong, L. A. Sepúlveda, R. Segev, and I. Golding, "General properties of transcriptional time series in Escherichia coli." Nature Genetics, 2011 May 1. [PubMed] See also: Nature Reviews Genetics Research Highlights, Human Frontier Science Program

L.-h. So, "Gene Regulation in Escherichia coli Beyond the 'Rate' Approximation." PhD thesis. Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL. [PDF]

C. Zong, L.-h. So, L. A. Sepúlveda, S. O. Skinner, and I. Golding, "Lysogen stability is determined by the frequency of activity bursts from the fate-determining gene." Molecular Systems Biology, 2010, 6:440 [PubMed]

S. Saini, S. Koirala, E. Floess, P. J. Mears, Y. R. Chemla, I. Golding, C. Aldridge, P. D. Aldridge, and C. V. Rao, "FliZ induces a kinetic switch in flagellar gene expression." J. Bacteriol., 2010 Dec;192(24):6477-81. [PubMed]

L. Zeng, S. O. Skinner, C. Zong, J. Sippy, M. Feiss and I. Golding, "Decision making at a subcellular level determines the outcome of bacteriophage infection." Cell, 2010 May 14, 141(4): 682-91. [PubMed] See also: BCM press, Nature Research Highlights

T. M. Min, P. J. Mears, L. M. Chubiz, C. V. Rao, I. Golding, and Y. R. Chemla, "High-resolution, long-term characterization of bacterial motility using optical tweezers" Nature Methods, 2009, 6, 831-5 [PubMed] See also: UIUC press

N. Chia, I. Golding and Nigel Goldenfeld. "Lambda-prophage induction modeled as a cooperative failure mode of lytic repression." Phys. Rev. E. Rapid Communications, 80, 030901 (R):1-4 (2009). [PubMed] See also: UIUC press

Y. Wang, L. Guo, I. Golding, E. C. Cox and N. P. Ong “Quantitative transcription factor binding kinetics at the single-molecule level” Biophys. J. 96 (2) 609-620 (2009).[PubMed]

I. Golding and E. C. Cox, “Spatiotemporal Dynamics in Bacterial Cells: Real-Time Studies with Single-Event Resolution”, In: H. W. Detrich, and J. J. Correia (Editors), METHODS IN CELL BIOLOGY, Vol. 89, BIOPHYSICAL TOOLS FOR BIOLOGISTS, VOL 2: IN VIVO TECHNIQUES, Academic Press (2008). [PubMed]

I. Golding and E. C. Cox “Protein synthesis molecule by molecule” Genome Biol. 7:212 (2006). [PubMed]

I. Golding and E. C. Cox, "Eukaryotic transcription: what does it mean for a gene to be 'on'?" Curr. Biol. 2006 May 23;16(10)R371-R373 [PubMed]

I. Golding and E. C. Cox, "Physical nature of bacterial cytoplasm", Phys. Rev. Lett. 2006 Mar 10;96(9):098 102. Epub 2006 Mar 10 [PubMed]

I. Golding, J. Paulsson, S. M. Zawilski and E. C. Cox, "Real-time kinetics of gene activity in individual bacteria", Cell, 2005, 123(6);1025-1036. [PubMed]

Y. M. Wang, J. O. Tegenfeldt, W. Reisner, R. Riehn, X.-J. Guan, L. Guo, I. Golding, E. C. Cox, J. Sturm and R. H. Austin “Single-molecule studies of repressor-DNA interactions show long-range interactions” Proc. Natl. Acad. Sci. USA 102 (28) 9796-9801 (2005). [PubMed]

Y. Chen, I. Golding, S. Sawai, L. Guo and E. C. Cox, "Population fitness and the regulation of Escherichia coli genes by bacterial viruses." PloS Biol. 2005 Jul 3(7):e229. Epub 2005 June 21. [PubMed]

I. Golding and E. C. Cox, "RNA dynamics in live E. coli cells." Proc. Natl. Acad. Sci USA, 2004 Aug 3;101(31) 11310-11315. [PubMed]

U. Nevo, I. Golding, A. U. Neumann, M. Schwartz and S. Akselrod “Autoimmunity as an immune defense against degenerative processes: a primary mathematical model illustrating the bright side of autoimmunity” Journal of Theoretical biology 227 (4) 583-592 (2004). [PubMed]

U. Nevo, J. Kipnis, I. Golding, I. Shaked, A. Neumann, S. Akselrod and M. Schwartz “Autoimmunity as a special case of immunity: removing threats from within” Trends in Molecular Medicine 9 (3) 88-93 (2003). [PubMed]

I.G. Ron, I. Golding, B. Lifsitz-Mercer and E. Ben-Jacob “Bursts of sectors in expanding bacterial colonies as a possible model for tumor growth and metastases” Physica A 320 485-496 (2003).

O. Shefi, I. Golding, R. Segev, E. Ben-Jacob and A. Ayali “Morphological characterization of in-vitro neuronal networks” Phys. Rev. E. 66 (2) 021905 (2002). [PubMed]

I. Golding, B. Drossel, Y. Shapira and E. Ben-Jacob “A Quantitative Study of the Dynamics of Adaptive Mutation Appearance” Physica A 294 (1-2) 195-212 (2001).

I. Golding and E. Ben-Jacob “The artistry of bacterial colonies and the antibiotic crisis” in Coherent Structures in Complex Systems (D. Reguera, L.L. Bonilla, and J.M. Rubí, Eds.), Springer-Verlag, Heidelberg (2001).

E. Ben-Jacob, I. Cohen, I. Golding, D.L. Gutnick, M. Tcherpakov, D. Helbing and I.G. Ron “Bacterial cooperative organization under antibiotic stress” Physica A 282 (1-2) 247-282 (2000).

I. Golding, I. Cohen and E. Ben-Jacob “Studies of sector formation in expanding bacterial colonies” Europhys. Lett. 48 (5) 587-593 (1999).

I. Cohen, I. Golding, Y. Kozlovsky and E. Ben-Jacob “Continuous and discrete models of cooperation in complex bacterial colonies” Fractals 7 (3) 235-247 (1999).

Y. Kozlovsky, I. Cohen, I. Golding and E. Ben-Jacob “Lubricating bacteria model for branching growth of bacterial colonies” Phys. Rev. E. 59 (6) 7025-7035 (1999).

I. Golding, Y. Kozlovsky, I. Cohen and E. Ben-Jacob “Studies of bacterial branching growth using reaction-diffusion models of colonial development” Physica A 260 (3-4) 510-554 (1998).

I. Golding and Y. Kantor “Two-dimensional polymers with random short-range interactions” Phys. Rev. E 56 (2) R1318-R1321 (1997).