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Genetic Labs

Houston, Texas

Genetic Laboratory
Medical Genetics Laboratories
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Medical Genetics Test Details

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Hereditary High Risk Breast Cancer Panel
Test Information: The High Risk Hereditary Breast Cancer Panel uses next-generation sequencing and deletion/duplication analysis to simultaneously analyze selected genes associated with an increased risk of breast cancer. Hereditary breast cancer accounts for approximately 10% of breast cancer cases. Approximately 25-50% of hereditary breast cancer cases have mutations in the BRCA1/2 genes. Additional high-risk breast cancer genes include CDH1, PALB2, PTEN, STK11 and TP53. In general, the test is used when a patient's medical history and family history findings strongly suggest that there is an underlying genetic etiology of breast cancer.
Test Details
Test Code: 9155
Special Notes: The panel includes exon by exon sequencing, indels and gross copy number analyses of 7 genes that associated with high risk of breast cancer.
Certain exons with no known gross deletion/duplication mutations may not be covered by deletion/duplication analysis.
A Hereditary Breast Cancer Panel (Test code: 9170) is also available, which is more comprehensive and includes 20 genes associated with breast/ovarian cancer.

For additional information, the following resources are available:
Hereditary Cancer Panels Gene List
Hereditary Breast Cancer Patient Guide

BRCA1 and BRCA2 gene sequencing and deletion/duplication analysis are performed via next generation sequencing by Counsyl.
Technical Information
Methodology: Next Generation Sequencing, Microarray and MLPA
Gene Name: BRCA1, BRCA2, CDH1, PALB2, PTEN, STK11, TP53
Sample & Shipping Information
Test Requisition: Cancer Molecular Germline
Specimen Type: Blood
Requirements: Draw blood in an EDTA (purple-top) tube(s). Send at least 5cc (children) or 10cc (adults).
Shipping Conditions: Ship at ambient temperature (18-25C/64-77F) in an insulated container by overnight courier. Do not heat or freeze.

Specimen Type: Purified DNA
Requirements: Send at least 5ug of purified DNA (minimal concentration of 50ng/uL; A260/A280 of ~1.7).
Shipping Conditions: Ship at ambient temperature (18-25C/64-77F) in an insulated container by overnight courier. Do not heat or freeze.

Turn Around Time: 3 - 4 weeks
Billing Information
List Price: *For Insurance or Institutional Prices, please call.
CPT Codes: 81211 x 1, 81321 x 1

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