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Genetic Labs

Houston, Texas

Genetic Laboratory
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Medical Genetics Test Details

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KRAS Mutation Analysis - Tumor
Test Information: Indication for Study:

Identification of mutations in codon 12, 13, and 61 of the KRAS gene.
Test Details
Test Code: 9041
Special Notes: This test can also be performed on FFPE samples (#9040).

KRAS is commonly mutated and thereby activated in various human cancers, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas, and colorectal carcinoma. The most common mutations of KRAS are concentrated at codons 12 and 13 (>90%) and less common codon 61 (~5-7%). These mutations render tumor resistance to various anti-cancer therapies.

Technical Limitations:

The sensitivity of detection is approximately 5-10 mutated cells per 100 total cells in the sample (5-10%).

Results of this test must always be interpreted in the context of relevant clinical and pathological data, and should not be used alone for a diagnosis of malignancy.

Useful Links:
- NCCN
- ASCO
- The Role of KRAS Mutation Testing in the Management of Colorectal Cancer
Technical Information
Methodology: Pyrosequencing®
Gene Name: KRAS
Protein Name: GTPase KRas
Test Type: Mutation Analysis
Sample & Shipping Information
Test Requisition: Tumor Analysis
Specimen Type: Bone Marrow
Requirements: 2-5 mL Bone Marrow (Min: 1 mL) in a EDTA (purple-top) tube(s).

Transport Temperature: Ship at ambient temperature (18-25°C/64-77°F).

Unacceptable Conditions: Frozen specimens.

Stability: Ambient: 48 hours; Frozen: Unacceptable

Shipping Conditions: Ship at ambient temperature (18-25°C/64-77°F) in an insulated container by overnight courier. Specimen should arrive in the laboratory within 48 hrs of collection. Do not heat or freeze.


Specimen Type: Fresh Frozen Tissue
Requirements: 150 mg (0.5-2.0 cm3) Fresh tissue snap frozen at -20°C. Store at -20°C.
Shipping Conditions: Ship on minimum of 10 lbs. of dry ice in an insulated container by overnight courier.


Specimen Type: Leukemic Blood
Requirements: 5-10 mL Leukemic Blood (Min: 1 mL) in a EDTA (purple-top) tube(s).

Transport Temperature: Ship at ambient temperature (18-25°C/64-77°F).

Unacceptable Conditions: Frozen specimens.

Stability: Ambient: 48 hours; Frozen: Unacceptable

Shipping Conditions: Ship at ambient temperature (18-25°C/64-77°F) in an insulated container by overnight courier. Specimen should arrive in the laboratory within 48 hrs of collection. Do not heat or freeze.



Turn Around Time: 7 - 10 days
Billing Information
List Price: *For Insurance or Institutional Prices, please call.
CPT Codes: 81275x1


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