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Pediatrics - Cain Pediatric Neurology Research Foundation

Houston, Texas

BCM pediatricians care for children in various clinical and hospital environments.
Gordon and Mary Cain Pediatric Neurology Research Foundation Laboratories
not shown on screen


(Cain Foundation members in bold)

Epilepsy and Seizures

Ljungberg MC, Sunnen CN, Lugo JN, Anderson AE, D'Arcangelo G. Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia.Dis Model Mech. 2009 Jul-Aug;2(7-8):389-98.

Barnwell LF, Lugo JN, Lee WL, Willis SE, Gertz SJ, Hrachovy RA, Anderson AE. Kv4.2 knockout mice demonstrate increased susceptibility to convulsant stimulation. Epilepsia. 2009 May 9.

Jacobs MP, Leblanc GG, Brooks-Kayal A, Jensen FE, Lowenstein DH, Noebels JL, Spencer DD, Swann JW. Curing epilepsy: progress and future directions. Epilepsy Behav. 2009 Mar;14(3):438-45.

Kelley MS, Jacobs MP, Lowenstein DH; NINDS Epilepsy Benchmark Stewards (Swann JW). The NINDS epilepsy research benchmarks. Epilepsia. 2009 Mar;50(3):579-82.

Schrader LA, Ren Y, Cheng F, Bui D, Sweatt JD, Anderson AE. Kv4.2 is a locus for PKC and ERK/MAPK cross-talk. Biochem J. 2009 Feb 1;417(3):705-15.

Swann JW. The spine loss paradox: clues to mechanisms and meaning.Epilepsy Curr. 2008 Nov-Dec;8(6):168-9.

Lugo JN, Barnwell LF, Ren Y, Lee WL, Johnston LD, Kim R, Hrachovy RA, Sweatt JD, Anderson AE. Altered phosphorylation and localization of the A-type channel, Kv4.2 in status epilepticus. J Neurochem. 2008 Aug;106(4):1929-40.

Nishimura M, Owens J, Swann JW. Effects of chronic network hyperexcitability on the growth of hippocampal dendrites. Neurobiol Dis. 2008 Feb;29(2):267-77.

Lee CL, Frost JD Jr, Swann JW, Hrachovy RA. A new animal model of infantile spasms with unprovoked persistent seizures. Epilepsia. 2008 Feb;49(2):298-307.

Swann JW, Le JT, Lee CL. Recurrent seizures and the molecular maturation of hippocampal and neocortical glutamatergic synapses. Dev Neurosci. 2007;29(1-2):168-78.

Jung S, Jones TD, Lugo JN Jr, Sheerin AH, Miller JW, D'Ambrosio R, Anderson AE, Poolos NP. Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy. J Neurosci. 2007 Nov 21;27(47):13012-21.

Lubin FD, Ren Y, Xu X, Anderson AE. Nuclear factor-kappa B regulates seizure threshold and gene transcription following convulsant stimulation. J Neurochem. 2007 Nov;103(4):1381-95.

Swann JW, Le JT, Lam TT, Owens J, Mayer AT. The impact of chronic network hyperexcitability on developing glutamatergic synapses. Eur J Neurosci. 2007 Aug;26(4):975-91.

Ren Y, Lyndon BF, Alexander JC, Lubin FD, Adelman JP, Pfaffinger PJ, Schrader LA, Anderson AE. Regulation of surface localization of the small-conductance CA2+-activated potassium channel, SK2 through direct phosphorylation by cylic amp-dependent protein kinase. J Biol Chem. 2006 Mar 2.

Schrader LA, Birnbaum SG, Nadin BM, Ren Y, Bui D, Anderson AE, Sweatt JD. ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit. Am J Physiol Cell Physiol. 2006 Mar;290(3):C852-61.

Fan Y, Fricker D, Brager DH, Chen X, Lu HC, Chitwood RA, Johnston D. Activity-dependent decrease of excitability in rat hippocampal neurons through increases in I(h). Nat Neurosci. 2005 Nov;8(11):1542-51.

Jiang M, Swann JW. A role for L-type calcium channels in the maturation of parvalbumin-containing hippocampal interneurons. Neuroscience. 2005 Sep 7

Lubin FD, Johnston LD, Sweatt JD, Anderson AE. Kainate mediates nuclear factor-kappa B activation in hippocampus via phosphatidylinositol-3 kinase and extracellular signal-regulated protein kinase. Neuroscience. 2005;133(4):969-81.

Swann JW. The impact of seizures on developing hippocampal networks. Prog Brain Res. 2005;147:347-54.

Shah MM, Anderson AE, Leung V, Lin X, Johnston D. Seizure-Induced Plasticity of h Channels in Entorhinal Cortical Layer III Pyramidal Neurons. Neuron. 2004 Oct 28;44(3):495-508.

Bernard C, Anderson A, Becker A, Poolos NP, Beck H, Johnston D. Acquired dendritic channelopathy in temporal lobe epilepsy. Science. 2004 Jul 23;305(5683):532-5.

Misonou H, Mohapatra DP, Park EW, Leung V, Zhen D, Misonou K, Anderson AE, Trimmer JS. Regulation of ion channel localization and phosphorylation by neuronal activity. Nature Neuroscience. 2004 Jul;7(7):711-8.

Varga AW, Yuan LL, Anderson AE, Schrader LA, Wu GY, Gatchel JR, Johnston D, Sweatt JD. Calcium-calmodulin-dependent kinase II modulates Kv4.2 channel expression and upregulates neuronal A-type potassium currents. Journal of Neuroscience. 2004 Apr 7;24(14):3643-54.

Swann JW. The effects of seizures on the connectivity and circuitry of the developing brain. Ment Retard Dev Disabil Res Rev. 2004;10(2):96-100.

Galvan CD, Wenzel JH, Dineley KT, Lam TT, Schwartzkroin PA, Sweatt JD, Swann JW. Postsynaptic contributions to hippocampal network hyperexcitability induced by chronic activity blockade in vivo. Eur J Neurosci. 2003 Oct;18(7):1861-72.

Brain Malformations and Cortical Development

Zhang G, Assadi AH, Roceri M, Clark GD, D'Arcangelo G. Differential interaction of the Pafah1b alpha subunits with the Reelin transducer Dab1.Brain Res. 2009 Apr 24;1267:1-8.

Dobyns WB, Mirzaa G, Christian SL, Petras K, Roseberry J, Clark GD, Curry CJ, McDonald-McGinn D, Medne L, Zackai E, Parsons J, Zand DJ, Hisama FM, Walsh CA, Leventer RJ, Martin CL, Gajecka M, Shaffer LG. Consistent chromosome abnormalities identify novel polymicrogyria loci in 1p36.3, 2p16.1-p23.1, 4q21.21-q22.1, 6q26-q27, and 21q2.Am J Med Genet A. 2008 Jul 1;146A(13):1637-54.

Assadi AH, Zhang G, McNeil R, Clark GD, D'Arcangelo G. Pafah1b2 mutations suppress the development of hydrocephalus in compound Pafah1b1; Reln and Pafah1b1; Dab1 mutant mice. Neurosci Lett. 2008 Jul 4;439(1):100-5.

Yabut O, Renfro A, Niu S, Swann JW, Marin O, D'Arcangelo G. Abnormal laminar position and dendrite development of interneurons in the reeler forebrain. Brain Res. 2007 Apr 6;1140:75-83.

Zhang G, Assadi AH, McNeil RS, Beffert U, Wynshaw-Boris A, Herz J, Clark GD, D'Arcangelo G. The Pafah1b Complex Interacts with the Reelin Receptor VLDLR. PLoS ONE. 2007 Feb 28;2:e252.

Ljungberg MC, Bhattacharjee MB, Lu Y, Armstrong DL, Yoshor D, Swann JW, Sheldon M, D'Arcangelo G. Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia. Ann Neurol. 2006 Oct;60(4):420-9.

Synaptic Plasticity and Barrel Map Development

She WC, Quairiaux C, Albright MJ, Wang YC, Sanchez DE, Chang PS, Welker E, Lu HC. Roles of mGluR5 in synaptic function and plasticity of the mouse thalamocortical pathway. Eur J Neurosci. 2009 Apr;29(7):1379-96.

Staley KJ, Anderson AE. Hyperactive interneurons impair learning in a neurofibromatosis model. Nat Neurosci. 2009 Jan;12(1):8-10.

Lauckner JE, Jensen JB, Chen HY, Lu HC, Hille B, Mackie K. GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2699-704.

Inan M, Lu HC, Albright MJ, She WC, Crair MC. Barrel map development relies on protein kinase A regulatory subunit II beta-mediated cAMP signaling. J Neurosci. 2006 Apr 19;26(16):4338-49.

Lu HC, Butts DA, Kaeser PS, She WC, Janz R, Crair MC. Role of efficient neurotransmitter release in barrel map development. J Neurosci. 2006 Mar 8;26(10):2692-703.

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