Academy of Bioastronautics: Postdoctoral Fellows
TRISH's postdoctoral fellowship program grants enable early career scientists to design, develop and conduct their own space-related research projects under the guidance of experienced faculty mentors. These fellows join the Academy of Bioastronautics, to share experiences and connect with to seasoned spaceflight experts. The academy is led by Dr. Larry Young, Apollo Program Professor Emeritus of Astronautics from the Massachusetts Institute of Technology.
Current TRISH Postdocs
Monitoring Biomarkers for Muscular Atrophy Using Nanoelectronic Chip for Astronaut Health
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Institution: NASA Ames Research Center
Mentor: Jessica Koehne, Ph.D.
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When muscles deteriorate, they produce a class of protein biomarkers called protease enzymes. If scientists can detect those biomarkers, they can more accurately monitor muscle atrophy. TRISH postdoctoral fellow Morgan Anderson is developing a portable, non-invasive diagnostic to monitor the progression of muscle atrophy over time. The instrument will use easy-to-use cartridges containing nine independent micro-electrodes. Each electrode will detect activity from a different biomarker, creating a “fingerprint” to monitor muscle atrophy during spaceflight. The data will help test the effectiveness of drug inhibitors.
Investigating the Effects of Simulated Microgravity Duration and Connexin 43 Deficiency on Bone Fracture Healing
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Institution: Virginia Commonwealth University
Mentor: Henry Donahue, Ph.D.
Investigating The Combinatorial Effects Of Intraocular Pressure And Hypobaric Hypoxia On Corneal Function
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Institution: Tufts University
Mentor: David Kaplan, Ph.D.
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Genetic Variability in Microgravity-Induced Bone and Muscle Loss
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Institution: Virginia Commonwealth University, Richmond, Va.
Mentor: Henry Donahue, Ph.D.
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Manipulating Sleep Architecture as an Operational Countermeasure
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Institution: University of Michigan, Ann Arbor
Mentor: Ben Dantzer, Ph.D.
Mechanisms of protection from radiation by natural proteins
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Institution: Baylor College of Medicine, Houston, Texas
Mentor: Susan Rosenberg, Ph.D.
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Development of Machine Learning-Derived Microbiological and Immune Signatures: Applications in Adaptive Risk Assessment of Infectious Disease During Spaceflight
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Institution: NASA Johnson Space Center
Mentor: C. Mark Ott, Ph.D.
In Situ Expression Analysis of Therapeutic Microbes with Gastrointestinal Devices
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Institution: Massachusetts Institute of Technology
Mentor: Robert Langer, ScD
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During the long duration of space travel to Mars, there will be limited resources available for astronauts. In particular, there is not enough room to store and refrigerate an unlimited supply of all the desired medicines you might need during a multiple year mission. TRISH postdoctoral fellow Miguel Jimenez is researching the use of therapeutic microorganisms, which may allow for a renewable source of specialized medicines. Astronauts may need to take only a small dose of microbial therapeutics to accomplish the same effect of traditional pills.
Effects of Galactic Cosmic Radiation on Translationally-Relevant Cognitive Behaviors and Response to Social Stress
Institution: Children's Hospital of Philadelphia
Mentor: Amelia Eisch, Ph.D.
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Utilizing NASA's Space Radiation Laboratory, TRISH postdoctoral fellow Frederico Kiffer and his research team will assess the effects of realistic space radiation exposures on the cognitive behavior of mice using a touchscreen-based platform. This touchscreen platform is similar to tests currently used to monitor the cognitive health of astronauts. In addition, Kiffer and his team will conduct unique social behavior experiments to evaluate the effects of space radiation exposures on aspects of social behavior and social stress resilience. And, the team will assess an experimental diet-based medication on its ability to prevent radiation-related cognitive and social complications.
Medical Oxygen Delivery System in Exploration Atmosphere Minimizing the Risk of Fire
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Institution: University of Hawaii, Honolulu
Mentor: Aaron Ohta, Ph.D.
Microgravity and Partial Gravity Effects on Hepatic Organoid Steatosis and Function
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Institution: University of California, San Francisco
Mentor: Tammy Chang, M.D., Ph.D.
Previously Funded Postdocs
Will use of long-acting, reversible contraceptives mitigate bone loss in female rats during simulated exploration class missions?
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Institution: Texas A&M University in College Station, Texas
Mentor: Susan Bloomfield, Ph.D.
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A mechanistic framework to assess the efficacy of aspirin and other radioprotectors to reduce carcinogenesis by space radiations
Institution: Columbia University in New York City, N.Y.
Mentor: David Brenner, Ph.D.
Investigation of blood-based circulating biomarkers of responses to space radiation
Institution: NASA Ames Research Center
Mentor: Sylvain Costes, Ph.D.
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TRISH postdoctoral fellow Eloise Pariset is identifying biomarker responses to ionizing particle radiation. Pariset is exploring whether these biomarkers can sufficiently spread radiation-induced cellular damage. Pariset’s investigation will help better understand the role of the immune system’s biomarkers in the spread of radiation damage. A better understanding of how radiation damage spreads could also help create novel treatments for astronauts exploring deep space.
Assessment of Artificial Gravity as a Countermeasure to Cephalad Fluid Shifting
Institution: Massachusetts General Hospital and Harvard Medical School in Boston, Mass.
Mentor: Quan Zhang, Ph.D.
Predicting individual differences in learning to manually stabilize attitude in a space flight analog environment
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Institution: Brandeis University in Waltham, Maine
Mentor: Paul DiZio, Ph.D.
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Scientific Physical And Operations Characterization (SPOC) – Capturing Physical Terrestrial Fieldwork In Context
Institution: University of Michigan
Mentor: Leia Stirling, Ph.D.
