Monitoring Biomarkers for Muscular Atrophy Using Nanoelectronic Chip for Astronaut Health
Institution: NASA Ames Research Center
Mentor: Jessica Koehne, Ph.D.
When muscles deteriorate, they produce a class of protein biomarkers called protease enzymes. If scientists can detect those biomarkers, they can more accurately monitor muscle atrophy. TRISH postdoctoral fellow Morgan Anderson is developing a portable, non-invasive diagnostic to monitor the progression of muscle atrophy over time. The instrument will use easy-to-use cartridges containing nine independent micro-electrodes. Each electrode will detect activity from a different biomarker, creating a “fingerprint” to monitor muscle atrophy during spaceflight. The data will help test the effectiveness of drug inhibitors.