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Urology

Houston, Texas

Scott Department of Urology
The Scott Department of Urology
not shown on screen

Gustavo Ayala, M.D.

Photo Gustavo Ayala, M.DR. Clarence and Irene H. Fulbright Chair in Pathology
Professor
Director, Surgical Pathology Fellowship Program
Department of Pathology and Scott Department of Urology

Education

M.D., National University of Asuncion
Residency Training, Anatomic Pathology, NCI, Aregua, Paraguay and Georgetown University Hospital Washington, DC, and Yale-New Haven Hospital, Yale University, New Haven, CT
Board Certified in Anatomic Pathology

Awards and Activities

  • Editorial Board of Human Pathology
  • Listed in "Best Doctors in America" (2009-2010)

Special Interests

The pathology of prostate cancer

Selected Publications

Li R, Erdamar S, Dai H, Sayeeduddin M, Frolov A, Wheeler TM, Ayala GE: Cytoplasmic accumulation of glycogen synthase kinase-3 (beta) is associated with aggressive clinicoopathological features in human prostate cancer. Anticancer Res 29:2077-2081, 2009.

Li R, Dai H, Wheeler TM, Sayeeduddin M, Scardino PT, Frolov A, Ayala GE: Prognostic value of Akt-1 in human prostate cancer: A computerized quantitative assessment with quantum dot techology. Clin Cancer Res 15:3568-3573, 2009.

Yanagisawa N, Li R, Rowley D, Hao L, Kadmon D, Miles BJ, Wheeler TM, Ayala G: Stromogenic prostatic carcinoma pattern (carcinomas with reactive stromal grade 3) in needle biopsies predicts biochemical recurrence-free survival in patients after radical prostatectomy. Hum Pathol 39:282-291, 2008 (republished).

Velazquez EF, Ayala G, Liu H, Chaux A, Zanotti M, Torres J, Cho SI, Barreto JE, Soares F, Cubilla AL: Histologic grade and perineural invasion are more inportant than tumor thickness as predictor of nodal metastasis in penile squamous cell carcinoma invading 5 to 10 mm. Am J Surg Pathol 32:974-979, 2008.

Yan J, Erdem H, Li R, Cai Y, Ayala G, Ittmann M, Yu-Lee LY, Tsai SY, Tsai MJ: Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression. Cancer Res 68:5460-5468, 2008.

Shao LJ, Shi HY, Ayala G, Rowley D, Zhang M: Haploinsufficiency of the maspin tumor suppressor gene leads to hyperplastic lesions in prostate. Cancer Res 68:5143-5151, 2008.

Mosquera J-M, Perner S, Genega EM, Sanda, M, Hofer MD, Mertz KD, Paris PL, Simko J, Bismar TA, Ayala G, Shah RB, Loda M, Rubin MA: Characterization of TMPRSS2-ERG fusion high-grade prostatic intraepithelial neoplasia and potential clinical implications. Clin Cancer Res 14:3380-3385, 2008.

Hammerich KH, Hille S, Ayala GE, Wheeler TM, Enger R, Ackermann R, Mueller-Mattheir V: Malignant advanced granulosa cell tumor of the adult testis: case report and review of the literature. Hum Pathol 39:701-709, 2008.

Hammerich KH, Ayala GE, Wheeler TM: Application of immunohistochemistry to the genitourinary system (prostate, urinary bladder, testis, and kidney). Arch Pathol Lab Med 132:432-440, 2008.

Ayala G, Yan J, Li,R, Ding Y, Thompson TC, Mims MP, Hayes TG, MacDonnell V, Lynch GR, Frolov A, Miles BJ, Wheeler TM, Harper JW, Tsai MJ, Ittmann M, Kadmon D: Bortezomib-mediated inhibition of steroid receptor coactivator-3 degradation leads to activated Akt. Clin Cancer Res 14:7511-7518, 2008.

Ayala,G, Dai H, Powell M, Li R, Ding Y, Wheeler TM, Shine D, Kadmon D, Thompson TC, Miles BJ, Ittmann MM, Rowley D: Cancer-related axonogenesis and neurogenesis in prostate cancer. Clin Cancer Res 14:7593-7603, 2008.

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