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Genetics Used to Personalize Heart Disease Treatment
According to the study's lead author, Ariel Brautbar, M.D., a Clinical Post-doctoral Fellow in Molecular and Human Genetics, of the 10,000 study participants, the results have the most importance to patients classified by traditional methods to be at "intermediate risk" defined as a 10 to 20 percent chance of having coronary heart disease in the next decade. "A person at high risk will be treated aggressively, regardless of whether he or she has this variation. A low-risk person with good health won't be treated differently either," Brautbar said. "However, someone in the intermediate risk group could be moved into a higher or lower risk category, depending on whether he or she has the genetic variant. This, in turn, could affect how he or she is treated." More than 16 percent in "intermediate risk" range had to be recategorized based on the analysis of their DNA. |
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Volume 4, Issue 3, Winter 2008 |
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| Last modified: December 29, 2008 |
A study at BCM has found a way to better predict a person's risk of heart attacks based on his or her genetics. Using drawn blood or saliva swabbed from the inside of the cheek, DNA can be analyzed for a genetic variation at a particular spot on chromosome 9. Those who have the DNA variation at the spot called 9p21 are considered at increased risk for heart attack or other heart disease event.