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The Coffee-Cholesterol ConnectionDid you know that cafestol, a compound found in coffee, elevates cholesterol? It's true. In fact, cafestol elevates cholesterol more than any other dietary agent, said David Moore, Ph.D., Professor of Molecular and Cellular Biology at BCM. Think de-caf is the answer? No luck. Removing caffeine does not remove cafestol, but using paper filters does. While the cafestol-cholesterol connection may be news to a lot of us, it's not new to researchers. But the mechanism by which cafestol acted has been a mystery, until Moore and postdoctoral student Marie-Louise Ricketts began tackling the issue in Moore's lab. What they found was that, in the intestine, cafestol activates the farsenoid X receptor (part of the body's own way of regulating levels of cholesterol) and induces FGF15, which reduces the effects of three liver genes that regulate cholesterol levels.  |
Best Minds Best MedicineBCM Campaign Seeks to Raise $1 Billion Attracting Stars: McNairs Give $100 Million To Recruit Top Scientists Lester and Sue Smith Gift Tackles Breast Cancer in the Clinic and Lab Two Alumni Share Commitment to Scholarship Support FeaturesTaking Personalized Medicine to New Heights Creating Culture While Building Walls Changing Complexion of Medicine SpotlightClick for your Doctor: New eVisits Trade Exam Room for Inbox Kjersti Aagaard: 2007 Winner of NIH New Innovator Award Getting World-Class Breast Cancer Care...With or Without Insurance James Lupski's Tenacity Founds New Field of Genomic Medicine BriefsBCM Named National Diabetes Research Center The Trash is no Place for Expired Medication Removing Brain Tumors Through the Nose SPORE Spawns New Lymphoma Efforts The Coffee-Cholesterol Connection
BCM Campaign puts Personalized Medicine on the Fast-Track
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Volume 4, Issue 1, Summer 2008 |
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| Last modified: October 7, 2008 |