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Living longer is smelly business

Could our sense of smell really affect how long we live? A recent study conducted at BCM using fruit flies lends evidence to the aromatic theory.

Other research has shown that reducing calories extends the lives of mice, and possibly humans. This new study—conducted by Scott Pletcher, Ph.D, Assistant Professor of Molecular and Human Genetics in the Huffington Center on Aging at BCM, and graduate student Sergiy Libert—showed that when a group of calorie-restricted flies were exposed to the smell of tasty yeast paste, they did not live as long as flies who were on identical diets but who were not exposed to the odor.

Using this information, the scientists looked into whether the lives of fruit flies could be lengthened if the gene that controlled their sense of smell could be altered. Sure enough, there was as much as a 57 percent lifespan extension—from 60 days to longer than 80 days—in the flies with the altered gene.

Although such a gene has not yet been described in mammals, Pletcher, Libert and colleagues suggest that this finding may be applicable in higher-level organisms such as mice, primates and humans, all of which have hundreds of odor receptors, many of which have not been carefully studied.

 

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Briefs

Living Longer is Smelly Business

Clinical Trials for Cancer Southward Bound

Green Tea Component Blocks HIV Cell Entry

Genetics Technique Takes Bite out of Research Barriers

Sports Legends Lend Helping Hands, Arms to College

Development & Alumni News

Mitchell Gift Furthers Brain Research

Lambert Receives Lifetime Achievement Award

Kleberg Foundation Gift Establishes RNAi Screening Core Facility

Alumnus Named White House Fellow

New Trustees Announced

 

Tailoring Technology to Benefit You, the Patient

 

     
 

Volume 3, Issue 2, Summer 2007

   
 

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  Last modified: October 10, 2008