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The articles are listed in chronological order, with the most recent publications at the top.
You can download pdf files of many articles by clicking on the [PDF] text by each listing.
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Rosen lab journal covers:
Click on the images to find out more information and view larger versions of the covers. |
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In Press |
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•Zhang M, Behbod F, Atkinson RA, Landis MD, Kittrell F, Edwards D, Medina D, Tsimelzon A, Hilsenbeck S, Green JE, Michalowska A and Rosen JM.
Identification of Tumor-initiating Cells in a p53 Null Mouse Model of Breast Cancer
Cancer Research. 2008 [Epub ahead of print] [Supplemental] |
| 2008 |
•Li X, Lewis MT, Huang J, Gutierrez C, Osborne CK, Wu MF, Hilsenbeck SG, Pavlick A, Zhang X, Chamness GC, Wong H, Rosen J, Chang JC.
Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy
J Natl Cancer Inst. 2008 May 7;100(9):672-9 [PDF] |
2007 |
•Vargo-Gogola T, Rosen JM.
Modeling breast cancer: One size does not fit all.
Nat. Rev. Cancer. 2007; 7:659-672. [PDF] |
•Heckman BM, Chakravarty G, Vargo-Gogola T, Gonzales-Rimbau M, Hadsell DL, Lee AV, Settleman J, Rosen JM.
Crosstalk between p190-B RhoGAP and IGF Signaling pathways is required for embryonic mammary bud development
Dev. Bio. 2007; 309(1):137-149. [PDF] |
•LaMarca HL, Rosen JM.
Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage
BCR. 2007; 9:304-306. [PDF] |
•Mukhopadhyay SS, Rosen JM.
The C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells
BBRC. 2007; 358: 770-776. [PDF] |
•Xian W, Schwertfeger KL, Rosen JM.
Distinct roles of FGFR1 and FGFR2 in regulating cell survival and epithelial-mesenchymal transition
Mol. Endo. 2007; 21(4):987-1000. [PDF] [Supp. Fig.] |
• Chen MS, Woodward WA, Behbod F, Peddibhotla S, Alfaro MP, Buchholz TA, Rosen JM
WNT/ß-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line
JCS. 2007: 120(3):468-477. [PDF] |
• Woodward WA, Chen MS, Behbod F, Alfaro MP, Buchholz TA, Rosen JM
WNT/ß-catenin mediates radiation resistance of mouse mammary progenitor cells
PNAS. 2007; 104(2):618-623. [PDF] [Supp. Fig.] [Erratum] |
• Buser AC, Gass Handel EK, Wyszomierski SL, Doppler W, Leonhardt SA, Schaack J, Rosen JM, Watkin H, Anderson SM, Edwards DP
Progesterone Receptor Repression of Prolactin/Stat5-Mediated Transcription of the ß-Casein Gene in Mammary Epithelial Cells
Mol Endo. 2007; 21(1):106-125. [PDF] |
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2006 |
• Kabotyanski EB, Hutter M, Xian W, Rijnkels M, and Rosen JM
Integration of prolactin and glucocorticoid signaling at the ß-casein promoter and enhancer by ordered
recruitment of specific transcription factors and chromatin modifiers
Mol Endo. 2006; 20(10):2355–2368. [PDF] |
• Grimm SL and Rosen JM
Stop! In the name of transforming growth factor-ß: keeping estrogen receptor-a-positive mammary epithelial cells from proliferating.
Breast Cancer Res. 2006; 8(4). [PDF] |
• Grimm SL, Bu W, Longley MA, Roop DR, Li Y, and Rosen JM
Keratin 6 is not essential for mammary gland development.
Breast Cancer Res. 2006; 8(3). [PDF] |
• Cella N, Contreras A, Latha K, Rosen JM, and Zhang M
Maspin is physically associated with ß1 integrin regulating cell adhesion in mammary epithelial cells.
FASEB. 2006; 20. [PDF] |
• Schwertfeger K, Xian W, Burnett SH, Kaplan AM, Cohen DA, and Rosen JM
A Critical Role for the Inflammatory Response in a Mouse Model of Breast Cancer Progression.
Cancer Res. 2006; 66: (11) 5676-5685. [PDF] [Supp. Fig] [Sup. Table 1] [Sup. Table 2] |
•Behbod F, Xian W, Shaw CA, Hilsenbeck SG, Tsimelzon A and Rosen JM.
Transcriptional Profiling of Mammary Gland Side Population Cells
Stem Cells. 2006; 24:1065-1074 [PDF] [Supp. Fig]
The data discussed in this publication have been deposited in NCBIs Gene Expression Omnibus (GEO, http://www.ncbi.nlm.nih.gov/geo/) and are accessible through GEO Series accession number GSE5309. |
•Ginger MR, Shore AN, Contreras A, Rijnkels M, Miller J, Gonzalez-Rimbau MF, and Rosen JM
A noncoding RNA is a potential marker of cell fate during mammary gland development
PNAS 2006 April 11; 103(15):5781-5786 [PDF] [Supp. Fig 1] [Supp. Fig 2] [Supp. Fig 3] [Supp. Fig 4] [Supp. Fig 5]
[Supp. Fig 6] [Supp. Methods] |
•Vargo-Gogola T, Heckman BM, Gunther EJ, Chodosh LA, Rosen JM.
P190-B RhoGAP overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland.
Mol Endocrinol. 2006 June; 20(6): 1391-1405. [PDF] |
•Zhang M, Rosen JM.
Stem cells in the etiology and treatment of cancer.
Curr Opin Genet Dev. 2006 Feb;16(1):60-64. [PDF] |
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2005 |
•Xian W, Schwertfeger KL, Vargo-Gogola T, Rosen JM.
Pleiotropic effects of FGFR1 on cell proliferation, survival and migration in a 3D mammary epithelial cell model
J Cell Biol, 2005 Nov 21; 171(4): 663-673 [PDF] |
•Grimm SL, Contreras A, Barcellos-Hoff MH and Rosen JM.
Cell cycle defects contribute to a block in hormone-induced mammary gland proliferation in C/EBPbeta-null mice
J Biol Chem, 2005 Oct 28; 280(43): 36301-36309 [PDF] |
•Woodward WA, Chen MS, Behbod F and Rosen JM. [Commentary]
On mammary stem cells
J Cell Sci, 2005 Aug 15;118(Pt 16):3585-94. [PDF] |
•Behbod F and Rosen JM. [Review]
Will cancer stem cells provide new therapeutic targets?
Carcinogenesis, 2005 Apr; 26(4): 703-711. [PDF] |
•Li Y and Rosen JM. [Review]
Stem/Progenitor Cells in Mouse Mammary Gland Development and Breast Cancer
J Mammary Gland Biol Neoplasia, 2005 Jan; 10(1): 17-24. [PDF] |
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2004 |
•Lam MH and Rosen JM. [Review]
Chk1 versus Cdc25: Chking One’s Levels of Cellular Proliferation.
Cell Cycle, 2004 Nov; 3(11): 1355-1357. [PDF] |
•Lam MH, Liu Q, Elledge SJ, and Rosen JM.
Chk1 is haploinsufficient for multiple functions critical to tumor suppression.
Cancer Cell, 2004 July; 6(1): 45-59. [PDF] |
•Rosen JM. [Book Chapter]
Molecular mechanisms regulating breast development.
In: Diseases of the Breast, Third Edition. Harris JR, Lippman ME, Morrow M and Osborne CK (eds).
Lippincott, Williams and Wilkins; Baltimore, MD, June 2004. [PDF]
Publishers LINK
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2003 |
•Rosen JM. [Review]
Hormone receptor patterning plays a critical role in normal lobuloalveolar development and breast cancer progression.
Breast Disease, 2003; 18: 3-9. [PDF] |
•Li Y, Welm B, Podsypanina K, Huang S, Chamorro M, Zhang X, Rowlands T, Egeblad M, Cowin P, Werb Z, Tan LK, Rosen JM and Varmus HE
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.
Proc Natl Acad Sci USA, 2003 Dec; 100(26): 15853-15858. [PDF] |
•Hernandez I, Maddison LA, Wei Y, DeMayo F, Petras T, Li B, Gingrich JR, Rosen JM, and Greenberg NM.
Prostate specific expression of p53 (R172L) differentially regulates p21, Bax and Mdm2 to inhibit prostate cancer progression and prolong survival.
Molecular Cancer Research, 2003 Dec; 1(14): 1036-1047. [PDF] |
•Freeman KW, Welm BE, Gangula RD, Rosen JM, Ittman M, Greenberg NM and Spencer DM.
Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional FGFR1-expressing mice.
Cancer Research, 2003 Dec; 63(23):8256-8263. [PDF] |
•Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen EL, Mizushima N, Ohsumi Y, Cattoretti G and Levine B.
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene.
J Clin Invest, 2003 Dec; 112(12): 1809-1820. [PDF] |
•Contreras A, Hale TK, Stenoien DL, Rosen JM, Mancini MA and Herrera RE.
The dynamic mobility of histone H1 is regulated by cyclin/CDK phosphorylation.
Mol Cell Biol, 2003 Dec; 23(23): 8626-8636. [PDF] |
•Freeman KW, Gangula RD, Welm BE, Ozen M, Foster BA, Rosen JM, Ittman M, Greenberg NM and Spencer DM.
Conditional activation of fibroblast growth factor receptor (FGFR1) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, ERK activation and in vivo proliferation.
Cancer Research, 2003 Oct; 63(19): 6237-6243. [PDF] |
•Welm BE, Behbod F, Goodell MA and Rosen JM. [Review]
Isolation and characterization of functional mammary gland stem cells
Cell Proliferation, 2003 Oct; 36(Suppl. 1): 17–32. [PDF] |
•Rijnkels M, Elnitski L, Miller W and Rosen JM.
Multi-species comparative analysis of a mammalian-specific genomic domain encoding secretory proteins.
Genomics, 2003 Oct; 82(4): 417-432. [PDF] |
•Rosen JM. [Commentary]
Striking it Rich Data Mining
Cell, 2003 August; 114: 1-2. [PDF] |
•Chakravarty G, Hadsell DL, Buitrago W, Settleman J, and Rosen JM.
p190-B RhoGAP regulates mammary ductal morphogenesis.
Molecular Endocrinology, 2003 June; 17(6): 1054-1065. [PDF] |
•Lee AV, Zhang P, Ivanova M, Bonnette S, Oesterreich S, Rosen JM, Grimm SL, Hovey RC, Vonderhaar BK, Kahn CR, Torres D, George J, Mohsin S, Allred DC, and Hadsell DL.
Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland.
Endocrinology, 2003 June; 144(6): 2683-2694. [PDF] |
•Kabotyanski EB and Rosen JM.
Signal transduction pathways regulated by prolactin and Src result in different conformations of activated Stat5b.
J Biol Chem, 2003 May; 278(19): 17218-17227. [PDF] |
•Grimm SL and Rosen JM. [Review]
The role of C/EBP beta in mammary gland development and breast cancer.
J Mammary Gland Biol Neoplasia, 2003 April; 8(2): 191-204. [PDF] |
•Rosen JM. [Review-Introduction]
Transcription Factors.
J Mammary Gland Biol Neoplasia, 2003 April; 8(2): 143-144. [PDF] |
•Ginger MR and Rosen JM. [Commentary]
Pregnancy-induced changes in cell-fate in the mammary gland.
Breast Cancer Research, 2003 April; 5(4): 1192-197. [PDF] |
•Pownall ME, Welm BE, Freeman KW, Spencer DM, Rosen JM and Isaacs HV.
An inducible system for the study of FGF signaling in early amphibian development.
Dev Biol. 2003 April; 256(1): 89-99. [PDF] |
•Medina D, Kittrell FS, Shepard A, Contreras A, Rosen JM and Lydon J.
Hormone dependence in premalignant mammary progression.
Cancer Research 2003 Mar; 63: 1067-1072. [PDF] |
•Tepera SB, McCrea PD and Rosen JM.
A ß-Catenin survival signal is required for normal lobular development in the mammary gland.
J Cell Science 2003 Mar; 116(6): 1137-1149. [PDF] |
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2002 |
•Grimm SL, Seagroves TN, Kabotyanski EB, Hovey RC, Vonderhaar BK, Lydon JP, Miyoshi K, Hennighausen L, Ormandy CJ, Lee AV, Stull, MA, Wood TL and Rosen JM.
Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development.
Mol Endocrinol. 2002 Dec; 16(12): 2675-2691. [PDF]
supplemental table [PDF] |
•Green JE, Cardiff R, Hennighausen L, Wakefield L, Wagner U, Lee E, Rosen J, Medina D, Nitkin A and Liu E.
Validation of transgenic mammary cancer models: goals of the NCI Mouse Models of Human Cancer Consortium and the mammary cancer CD-ROM.
Transgenic Res. 2002 Dec; 11: 635-636. [PDF] |
•Kingsley-Kallesen M, Mukhopadhyay SS, Wyszomierski SL, Schanler S, Schutz G and Rosen JM.
The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development.
Mol Endocrinol. 2002 Sept; 16(9): 2008-2018. [PDF] |
•Rijnkels M [Review]
Multispecies Comparison of the Casein Gene Loci and Evolution of Casein Gene Family.
J Mammary Gland Biol Neoplasia. 2002 July; 7(3):327-345. [PDF] |
•Welm BE, Freeman KW, Chen M, Contreras A, Spencer DM and Rosen JM.
Inducible dimerization of FGFRI: development of a mouse model to analyze progressive transformation of the mammary gland.
J Cell Biol. 2002 May; 157(4): 703-714. [PDF] |
•Welm BE, Tepera SB, Venezia T, Graubert TA, Rosen JM and Goodell MA.
Sca-1pos cells in the mouse mammary gland represent an enriched progenitor cell population.
Dev Biol. 2002 May; 245(1): 42-56. [PDF] |
•Shillingford JM, Miyoshi K, Robinson GW, Grimm SL, Rosen JM, Neubauer H, Pfeffer K and Hennighausen L.
Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium.
Mol Endocrinol. 2002 Mar; 16(3): 563-570. [PDF] |
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2001 |
·Miyoshi K, Shillingford JM, Smith GH, Grimm SL, Wagner KU, Oka T, Rosen JM, Robinson GW and Hennighausen L.
Signal transducer and activator transcription 5 (Stat5) controls the proliferation and differentiation of mammary alveolar epithelium.
J Cell Biol. 2001 Nov; 155(4): 531-542. [PDF] |
·Ginger MR, Gonzalez-Rimbau MF, Gay JP and Rosen JM.
Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary gland.
Mol Endocrinol. 2001 Nov; 15(11): 1993-2009. [PDF] |
·Mukhopadhyay SS, Wyszomierski SL, Gronostajski RM and Rosen JM.
Differential interactions of specific Nuclear Factor I isoforms with the glucocorticoid receptor and STAT5 in the cooperative regulation of WAP gene transcription.
Mol Cell Biol. 2001 Oct; 21(20):6859-6869. [PDF] |
·Rijnkels M and Rosen JM.
AdCre1-mediated recombination in mammary epithelial cells.
J Cell Science. 2001 Sept; 114(17): 3147-3153. [PDF] |
·Seagroves TN and Rosen JM. [Book Chapter]
Control of mammary epithelial proliferation: The unique role of the progesterone receptor.
In: Sex Hormones and Cell Cycle Regulation; Kerry Burnstein (Ed).
Kluwer Press, 2001 pp 33-55. [PDF] |
·Seagroves TN and Rosen JM. [Book Chapter]
Knockout and transgenic mouse models that have contributed to the understanding of normal mammary gland development.
In: Contemporary Endocrinology, Transgenics in Endocrinology; Kumar R, Brown C, and Matzuk MM (eds).
Humana Press, NJ 2001 pp 205-229. [PDF] |
·Kazansky AV and Rosen JM.
Signal transducers and activators of transcription 5B potentiates v-Src mediated transformation of NIH-3T3 cells.
Cell Growth Differ. 2001 Jan; 12(1):1-7. [PDF] |
·Wyszomierski SL and Rosen JM.
Cooperative effects of STAT5 (Signal transducer and activator of transcription 5) and C/EBPbeta (CCAAT/enhancer-binding protein-beta) on beta-casein gene transcription are mediated by the glucocorticoid receptor.
Mol Endocrinol. 2001 Feb; 15(2):228-240. [PDF] |
·Zahnow CA, Cardiff RD, Laucirica R, Medina D, Rosen JM.
A role for CCAAT/enhancer binding protein beta-liver-enriched inhibitory protein in mammary epithelial cell proliferation.
Cancer Res. 2001 Jan 1; 61(1):261-269. [PDF] |
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2000 |
·Murphy KL, Dennis AP, Rosen JM.
A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53-null mammary epithelial cell model.
FASEB J. 2000 Nov; 14(14):2291-2302. [PDF] |
·Chakravarty G, Roy D, Gonzales M, Gay J, Contreras A, Rosen JM.
P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer.
Cell Growth Differ. 2000 Jul; 11(7):343-354. [PDF] |
·Seagroves TN, Lydon JP, Hovey RC, Vonderhaar BK, Rosen JM.
C/EBPbeta (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development.
Mol Endocrinol. 2000 Mar; 14(3):359-368. [PDF] |
·Murphy KL, Rosen JM. [Review]
Mutant p53 and genomic instability in a transgenic mouse model of breast cancer.
Oncogene. 2000 Feb 21; 19(8):1045-1051. [PDF] |
·Hadsell DL, Murphy KL, Bonnette SG, Reece N, Laucirica R, Rosen JM.
Cooperative interaction between mutant p53 and des(1-3)IGF-I accelerates mammary tumorigenesis.
Oncogene. 2000 Feb 17; 19(7):889-898. [PDF] |
·Murphy KL, Grimm SL, and Rosen JM. [Meeting Review]
Modeling Mammary Cancer in Mice Conference
Jackson Laboratory, Bar Harbor, Maine, 5–8 October, 1999
Breast Cancer Res. 2000 Jan; 2(1):E003. [PDF] |
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1999 |
·Murphy KL, Kittrell FS, Gay JP, Jager R, Medina D, Rosen JM.
Bcl-2 expression delays mammary tumor development in dimethylbenz(a)anthracene-treated transgenic mice.
Oncogene. 1999 Nov 11; 18(47):6597-6604. [PDF] |
·Rosen JM, Wyszomierski SL, Hadsell DL. [Review]
Regulation of milk protein gene expression.
Annu Rev Nutr. 1999; 19:407-436. [PDF] |
·Kazansky AV, Kabotyanski EB, Wyszomierski SL, Mancini MA, Rosen JM.
Differential effects of prolactin and src/abl kinases on the nuclear translocation of STAT5B and STAT5A.
J Biol Chem. 1999 Aug 6; 274(32):22484-22492. [PDF] |
·Wyszomierski SL, Yeh J, Rosen JM.
Glucocorticoid receptor/signal transducer and activator of transcription 5 (STAT5) interactions enhance STAT5 activation by prolonging STAT5 DNA binding and tyrosine phosphorylation.
Mol Endocrinol. 1999 Feb; 13(2):330-343. [PDF] |
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1998 |
·Seagroves TN, Krnacik S, Raught B, Gay J, Burgess-Beusse B, Darlington GJ, Rosen JM.
C/EBPbeta, but not C/EBPalpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland.
Genes Dev. 1998 Jun 15; 12(12):1917-1928. [PDF] |
·Li B, Murphy KL, Laucirica R, Kittrell F, Medina D, Rosen JM.
A transgenic mouse model for mammary carcinogenesis.
Oncogene. 1998 Feb 26; 16(8):997-1007. [PDF] |
·Rosen JM, Zahnow C, Kazansky A, Raught B. [Book Chapter]
Composite response elements mediate hormonal and developmental regulation of milk protein gene expression.
Biochem Soc Symp. 1998; 63:101-113. [link to buy book] |
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1997 |
·Zahnow CA, Younes P, Laucirica R, Rosen JM.
Overexpression of C/EBPbeta-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer.
J Natl Cancer Inst. 1997 Dec 17; 89(24):1887-1891. [PDF] |
·Humphreys RC, Lydon JP, O'Malley BW, Rosen JM. [Review]
Use of PRKO mice to study the role of progesterone in mammary gland development.
J Mammary Gland Biol Neoplasia. 1997 Oct; 2(4):343-354. [PDF] |
·Humphreys RC, Rosen JM.
Stably transfected HC11 cells provide an in vitro and in vivo model system for studying Wnt gene function.
Cell Growth Differ. 1997 Aug; 8(8):839-849. [link to abstract] |
·Humphreys RC, Lydon J, O'Malley BW, Rosen JM.
Mammary gland development is mediated by both stromal and epithelial progesterone receptors.
Mol Endocrinol. 1997 Jun;11(6):801-811. [PDF] |
·Li B, Rosen JM, McMenamin-Balano J, Muller WJ, Perkins AS.
neu/ERBB2 cooperates with p53-172H during mammary tumorigenesis in transgenic mice.
Mol Cell Biol. 1997 Jun;17(6):3155-3163. [PDF] |
·Yarus S, Weaver TE, Rosen JM.
The carboxy-teminal domain of human surfactant protein B is not required for secretion in milk of transgenic mice
Front Biosci. 1997 May 1;2:a1-8. [link to full text] |
·Yarus S, Greenberg NM, Wei Y, Whitsett JA, Weaver TE, Rosen JM.
Secretion of unprocessed human surfactant protein B in milk of transgenic mice.
Transgenic Res. 1997 Jan;6(1):51-57. [PDF] |
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1996 |
·Humphreys RC, Krajewska M, Krnacik S, Jaeger R, Weiher H, Krajewski S, Reed JC, Rosen JM.
Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis.
Development. 1996 Dec;122(12):4013-4022. [PDF] |
·Yarus S, Rosen JM, Cole AM, Diamond G.
Production of active bovine tracheal antimicrobial peptide in milk of transgenic mice.
Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14118-14121. [PDF] |
·Raught B, Gingras AC, James A, Medina D, Sonenberg N, Rosen JM.
Expression of a translationally regulated, dominant-negative CCAAT/enhancer-binding protein beta isoform and up-regulation of the eukaryotic translation initiation factor 2alpha are correlated with neoplastic transformation of mammary epithelial cells.
Cancer Res. 1996 Oct 1;56(19):4382-4386. [link to abstract] |
·Gingrich JR, Barrios RJ, Morton RA, Boyce BF, DeMayo FJ, Finegold MJ, Angelopoulou R, Rosen JM, Greenberg NM.
Metastatic prostate cancer in a transgenic mouse.
Cancer Res. 1996 Sep 15;56(18):4096-4102. [link to abstract] |
·Rosen JM, Li S, Raught B, Hadsell DL. [Review]
The mammary gland as a bioreactor: factors regulating the efficient expression of milk protein-based transgenes.
Am J Clin Nutr. 1996 Apr;63(4):627S-632S. |
·Yarus S, Hadsell DL, Rosen JM. [Review]
Engineering transgenes for use in the mammary gland.
Genet Eng (N Y). 1996;18:57-81. |
·Hadsell DL, Greenberg NM, Fligger JM, Baumrucker CR, Rosen JM.
Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression.
Endocrinology. 1996 Jan;137(1):321-330. [PDF] |
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1995 |
·Kazansky AV, Raught B, Lindsey SM, Wang YF, Rosen JM.
Regulation of mammary gland factor/Stat5a during mammary gland development.
Mol Endocrinol. 1995 Nov;9(11):1598-1609. [PDF] |
·Li B, Kittrell FS, Medina D, Rosen JM.
Delay of dimethylbenz[a]anthracene-induced mammary tumorigenesis in transgenic mice by apoptosis induced by an unusual mutant p53 protein.
Mol Carcinog. 1995 Oct;14(2):75-83. |
·Raught B, Liao WS, Rosen JM.
Developmentally and hormonally regulated CCAAT/enhancer-binding protein isoforms influence beta-casein gene expression.
Mol Endocrinol. 1995 Sep;9(9):1223-1232. [PDF] |
·Wei Y, Yarus S, Greenberg NM, Whitsett J, Rosen JM.
Production of human surfactant protein C in milk of transgenic mice.
Transgenic Res. 1995 Jul;4(4):232-240. |
·Krnacik MJ, Li S, Liao J, Rosen JM.
Position-independent expression of whey acidic protein transgenes.
J Biol Chem. 1995 May 12;270(19):11119-11129. [PDF] |
·Greenberg NM, DeMayo F, Finegold MJ, Medina D, Tilley WD, Aspinall JO, Cunha GR, Donjacour AA, Matusik RJ, and Rosen JM.
Prostate cancer in a transgenic mouse.
Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3439-3443. [PDF] |
·Li S and Rosen JM.
Nuclear factor I and mammary gland factor (STAT5) play a critical role in regulating rat whey acidic protein gene expression in transgenic mice.
Mol Cell Biol. 1995 Apr;15(4):2063-2070. [PDF] |
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1994 |
·Li S and Rosen JM.
Glucocorticoid regulation of rat whey acidic protein gene expression involves hormone-induced alterations of chromatin structure in the distal promoter region.
Mol Endocrinol. 1994 Oct;8(10):1328-1335. [PDF] |
·Li B, Greenberg N, Stephens LC, Meyn R, Medina D, Rosen JM.
Preferential overexpression of a 172Arg-->Leu mutant p53 in the mammary gland of transgenic mice results in altered lobuloalveolar development.
Cell Growth Differ. 1994 Jul;5(7):711-721. |
·Li S and Rosen JM.
Distal regulatory elements required for rat whey acidic protein gene expression in transgenic mice.
J Biol Chem. 1994 May 13;269(19):14235-14243. [PDF] |
·Greenberg NM, DeMayo FJ, Sheppard PC, Barrios R, Lebovitz R, Finegold M, Angelopoulou R, Dodd JG, Duckworth ML, Rosen JM.
The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice.
Mol Endocrinol. 1994 Feb;8(2):230-239. [PDF] |
·Coleman-Krnacik S and Rosen JM.
Differential temporal and spatial gene expression of fibroblast growth factor family members during mouse mammary gland development.
Mol Endocrinol. 1994 Feb;8(2):218-229. [PDF] |
·Rosen JM, Humphreys R, Krnacik S, Juo P, Raught B. [Review]
The regulation of mammary gland development by hormones, growth factors, and oncogenes.
Prog Clin Biol Res. 1994;387:95-111. |
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1993 |
·Buhler TA, Dale TC, Kieback C, Humphreys RC, Rosen JM.
Localization and quantification of Wnt-2 gene expression in mouse mammary development.
Dev Biol. 1993 Jan;155(1):87-96. [PDF] |
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1992 |
·Wolff J, Wong C, Cheng H, Poyet P, Butel JS, Rosen JM.
Differential effects of the simian virus 40 early genes on mammary epithelial cell growth, morphology, and gene expression.
Exp Cell Res. 1992 Sep;202(1):67-76. |
·Dale TC, Krnacik MJ, Schmidhauser C, Yang CL, Bissell MJ, Rosen JM.
High-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3' untranslated region.
Mol Cell Biol. 1992 Mar;12(3):905-914. [link to abstract] |
·Greenberg NM, Wolfe J, Rosen JM. [Review]
Casein gene expression: from transfection to transgenics.
Cancer Treat Res. 1992;61:379-397. |
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1991 |
·Greenberg NM, Anderson JW, Hsueh AJ, Nishimori K, Reeves JJ, deAvila DM, Ward DN, Rosen JM.
Expression of biologically active heterodimeric bovine follicle-stimulating hormone in milk of transgenic mice.
Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8327-8331. [PDF] |
·Greenberg NM, Reding TV, Duffy T, Rosen JM.
A heterologous hormone response element enhances expression of rat beta-casein promoter-driven chloramphenicol acetyltransferase fusion genes in the mammary gland of transgenic mice.
Mol Endocrinol. 1991 Oct;5(10):1504-1512. [link to abstract] |
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1990 |
·Goodman HS and Rosen JM.
Transcriptional analysis of the mouse beta-casein gene.
Mol Endocrinol. 1990 Nov;4(11):1661-1670. [link to abstract] |
·Bayna EM and Rosen JM.
Tissue-specific, high level expression of the rat whey acidic protein gene in transgenic mice.
Nucleic Acids Res. 1990 May 25;18(10):2977-2985. [link to abstract] |
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The 1980s |
·Rosen JM, Bayna EM, Lee KF. [Review]
Analysis of milk protein gene expression in transgenic mice.
Mol Biol Med. 1989 Dec;6(6):501-509. |
·Poyet P, Henning SJ, Rosen JM.
Hormone-dependent beta-casein mRNA stabilization requires ongoing protein synthesis.
Mol Endocrinol. 1989 Dec;3(12):1961-1968. [link to abstract] |
·Lee KF, Atiee SH, Henning SJ, Rosen JM.
Relative contribution of promoter and intragenic sequences in the hormonal regulation of rat beta-casein transgenes.
Mol Endocrinol. 1989 Mar;3(3):447-453. [link to abstract] |
·Dale TC, Rosen JM, Guille MJ, Lewin AR, Porter AG, Kerr IM, Stark GR.
Overlapping sites for constitutive and induced DNA binding factors involved in interferon-stimulated transcription.
EMBO J. 1989 Mar;8(3):831-839. [link to abstract] |
·Lee KF, Atiee SH, Rosen JM.
Differential regulation of rat beta-casein-chloramphenicol acetyltransferase fusion gene expression in transgenic mice.
Mol Cell Biol. 1989 Feb;9(2):560-565. |
·Rosen JM, Poyet P, Goodman H, Lee KF.
Mechanisms by which prolactin and glucocorticoids regulate casein gene expression.
Biochem Soc Symp. 1989;55:115-123. |
·Eisenstein RS and Rosen JM.
Both cell substratum regulation and hormonal regulation of milk protein gene expression are exerted primarily at the posttranscriptional level.
Mol Cell Biol. 1988 Aug;8(8):3183-3190. |
·Campbell SM, Taha MM, Medina D, Rosen JM.
A clonal derivative of mammary epithelial cell line COMMA-D retains stem cell characteristics of unique morphological and functional heterogeneity.
Exp Cell Res. 1988 Jul;177(1):109-121. |
·Yu-Lee LY and Rosen JM.
A transfected alpha-casein minigene bypasses posttranscriptional control by hormones, but retains cell-substratum regulation in mammary epithelial cells.
Mol Endocrinol. 1988 May;2(5):431-443. [link to abstract] |
·Lee KF, DeMayo FJ, Atiee SH, Rosen JM.
Tissue-specific expression of the rat beta-casein gene in transgenic mice.
Nucleic Acids Res. 1988 Feb 11;16(3):1027-1041. [link to abstract] |
·Brown TL and Rosen JM.
Isolation and characterization of milk protein nuclear RNAs in rat mammary gland.
Anal Biochem. 1986 Mar;153(2):211-220. |
·Yu-Lee LY, Richter-Mann L, Couch CH, Stewart AF, Mackinlay AG, Rosen JM.
Evolution of the casein multigene family: conserved sequences in the 5' flanking and exon regions.
Nucleic Acids Res. 1986 Feb 25;14(4):1883-1902. [link to abstract] |
·Rosen JM, Rodgers JR, Couch CH, Bisbee CA, David-Inouye Y, Campbell SM, Yu-Lee LY. [Review]
Multihormonal regulation of milk protein gene expression.
Ann N Y Acad Sci. 1986;478:63-76. |
·Rosen JM, Jones WK, Rodgers JR, Compton JG, Bisbee CA, David-Inouye Y, Yu-Lee LY.
Regulatory sequences involved in the hormonal control of casein gene expression.
Ann N Y Acad Sci. 1986;464:87-99. |
·Johnson ML, Levy J, Rosen JM.
Maintenance of milk protein gene expression in a subpopulation of 7,12 dimethylbenz(a)anthracene-induced rat mammary carcinoma cells grown on attached collagen gels.
In Vitro Cell Dev Biol. 1985 Aug;21(8):439-444. |
·Jones WK, Yu-Lee LY, Clift SM, Brown TL, Rosen JM.
The rat casein multigene family. Fine structure and evolution of the beta casein gene.
J Biol Chem. 1985 Jun 10;260(11):7042-7050. [PDF] |
·Rodgers JR, Johnson ML, Rosen JM.
Measurement of mRNA concentration and mRNA half-life as a function of hormonal treatment.
Methods Enzymol. 1985;109:572-592. |
·Campbell SM, Rosen JM, Hennighausen LG, Strech-Jurk U, Sippel AE.
Comparison of the whey acidic protein genes of the rat and mouse.
Nucleic Acids Res. 1984 Nov 26;12(22):8685-8697. [link to abstract] |
·Johnson ML, Levy J, Supowit SC, Yu-Lee LY, Rosen JM.
Tissue- and cell-specific casein gene expression. II. Relationship to site specific DNA methylation.
J Biol Chem. 1983 Sep 10;258(17):10805-10811. [PDF] |
·Yu-Lee LY and Rosen JM.
The rat casein multigene family. I. Fine structure of the gamma-casein gene.
J Biol Chem. 1983 Sep 10;258(17):10794-10804. [PDF] |
·Johnson ML, Levy J, Rosen JM.
Isolation and characterization of casein-producing and -nonproducing cell populations from 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinomas.
Cancer Res. 1983 May;43(5):2199-2209. [link to abstract] |
·Hobbs AA, Rosen JM.
Sequence of rat alpha- and gamma-casein mRNAs: evolutionary comparison of the calcium-dependent rat casein multigene family.
Nucleic Acids Res. 1982 Dec 20;10(24):8079-8098. [link to abstract] |
·Hennighausen LG, Sippel AE, Hobbs AA, Rosen JM.
Comparative sequence analysis of the mRNAs coding for mouse and rat whey protein.
Nucleic Acids Res. 1982 Jun 25;10(12):3733-3744. [link to abstract] |
·Hobbs AA, Richards DA, Kessler DJ, Rosen JM.
Complex hormonal regulation of rat casein gene expression.
J Biol Chem. 1982 Apr 10;257(7):3598-3605. [PDF] |
·Blackburn DE, Hobbs AA, Rosen JM.
Rat beta casein cDNA: sequence analysis and evolutionary comparisons.
Nucleic Acids Res. 1982 Apr 10;10(7):2295-2307. [link to abstract] |
·Gupta P, Rosen JM, D'Eustachio P, Ruddle FH.
Localization of the casein gene family to a single mouse chromosome.
J Cell Biol. 1982 Apr;93(1):199-204. [PDF] |
·Supowit SC and Rosen JM.
Hormonal induction of casein gene expression limited to a small subpopulation of 7,12-dimethylbenz(a)anthracene-induced mammary tumor cells.
Cancer Res. 1982 Apr;42(4):1355-1360. [link to abstract] |
·Supowit SC and Rosen JM.
Tumor-specific polyadenylated RNA's from 7,12 dimethylbenz(a)anthracene-induced mammary tumors revealed through hybridization with fractionated single-copy DNA.
Cancer Res. 1981 Oct;41(10):3827-3834. (no abstract) |
·Richards DA, Rodgers JR, Supowit SC, Rosen JM.
Construction and preliminary characterization of the rat casein and alpha lactalbumin cDNA clones.
J Biol Chem. 1981 Jan 10;256(1):526-532. [PDF] |
·Richards DA, Blackburn DE, Rosen JM.
Restriction enzyme mapping and heteroduplex analysis of the rat milk protein cDNA clones.
J Biol Chem. 1981 Jan 10;256(1):533-538. [PDF] |
·Supowit SC and Rosen JM.
Gene expression in normal and neoplastic mammary tissue.
Biochemistry. 1980 Jul 22;19(15):3452-3460. [PDF] |
·Warner MR, Yau L, Rosen JM.
Long term effects of perinatal injection of estrogen and progesterone on the morphological and biochemical development of the mammary gland.
Endocrinology. 1980 Mar;106(3):823-832. [link to abstract] |
·Rosen JM, Matusik RJ, Richards DA, Gupta P, Rodgers JR. [Review]
Multihormonal regulation of casein gene expression at the transcriptional and posttransciptional levels in the mammary gland.
Recent Prog Horm Res. 1980;36:157-193. |
·Matusik RJ and Rosen JM.
Prolactin regulation of casein gene expression: possible mediators.
Endocrinology. 1980 Jan;106(1):252-259. (no abstract) |
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|
The 1970s |
·Guyette WA, Matusik RJ, Rosen JM.
Prolactin-mediated transcriptional and post-transcriptional control of casein gene expression.
Cell. 1979 Aug;17(4):1013-1023. |
·Dudley JP, Butel JS, Socher SH, Rosen JM.
Detection of mouse mammary tumor virus RNA in BALB/c tumor cell lines of nonviral etiologies.
J Virol. 1978 Dec;28(3):743-752. |
·Dudley JP, Rosen JM, Butel JS.
Differential expression of poly(A)-adjacent sequences of mammary tumor virus RNA in murine mammary cells.
Proc Natl Acad Sci U S A. 1978 Dec;75(12):5797-5801. [PDF] |
·Vonderhaar BK, Smith GH, Pauley RJ, Rosen JM, Topper YJ.
Difference between mammary epithelial cells from mature virgin and primiparous mice.
Cancer Res. 1978 Nov;38(11 Pt 2):4059-4065. [link to abstract] |
·Pauley RJ, Rosen JM, Socher SH.
Mammary tumour virus and casein gene transcription during mouse mammary development.
Nature. 1978 Oct 5;275(5679):455-457. |
·Matusik RJ and Rosen JM.
Prolactin induction of casein mRNA in organ culture. A model system for studying peptide hormone regulation of gene expression.
J Biol Chem. 1978 Apr 10;253(7):2343-2347. [PDF] |
·Rosen JM, O'Neal DL, McHugh JE, Comstock JP.
Progesterone-mediated inhibition of casein mRNA and polysomal casein synthesis in the rat mammary gland during pregnancy.
Biochemistry. 1978 Jan 24;17(2):290-297. [PDF] |
·Rosen JM and Socher SH.
Detection of casein messenger RNA in hormone-dependent mammary cancer by molecular hybridisation.
Nature. 1977 Sep 1;269(5623):83-86. |
·Chan L, Harris SE, Rosen JM, Means AR, O'Malley BW. [Review]
Processing of nuclear heterogeneous RNA: recent developments.
Life Sci. 1977 Jan 1;20(1):1-15. |
·Rosen JM.
Isolation and characterization of purified rat casein messenger ribonucleic acids.
Biochemistry. 1976 Nov 30;15(24):5263-5271. [PDF] |
·Rosen JM and Barker SW.
Quantitation of casein messenger ribonucleic acid sequences using a specific complementary DNA hybridization probe.
Biochemistry. 1976 Nov 30;15(24):5272-5280. [PDF] |
·Woo SL, Rosen JM, Liarakos CD, Choi YC, Busch H, Means AR, O'Malley BW.
Physical and chemical characterization of purified ovalbumin messenger RNA.
J Biol Chem. 1975 Sep 10;250(17):7027-7039. [PDF] |
·Rosen JM, Chan L, Woo SL, Harris SE, Means AR, O'Malley BW.
Effect of estrogen on the synthesis and processing of ovalbumin messenger RNA in the chick oviduct.
Brookhaven Symp Biol. 1975 Jul;(26):320-332. |
·Rosen JM, Woo SL, Comstock JP.
Regulation of casein messenger RNA during the development of the rat mammary gland.
Biochemistry. 1975 Jul;14(13):2895-2903. [PDF] |
·Harris SE, Rosen JM, Means AR, O'Malley BW.
Use of a specific probe for ovalbumin messenger RNA to quantitate estrogen-induced gene transcripts.
Biochemistry. 1975 May 20;14(10):2072-2081. [PDF] |
·O'Malley BW, Woo SL, Harris SE, Rosen JM, Means AR.
Steroid hormone regulation of specific messenger RNA and protein synthesis in eukaryotic cells.
J Cell Physiol. 1975 Apr;85(2 Pt 2 Suppl 1):343-356. |
·Rosen JM, Woo SL, Holder JW, Means AR, O'Malley BW.
Preparation and preliminary characterization of purified ovalbumin messenger RNA from the hen oviduct.
Biochemistry. 1975 Jan 14;14(1):69-78. [PDF] |
·Rosen JM, Harris SE, Rosenfeld GC, Liarakos CD, O'Malley BW.
Effect of estrogen on gene expression in the chick oviduct. 3. Hybridization studies with (3H) messenger RNA and (3H) complementary DNA under conditions of DNA excess.
Cell Differ. 1974 Jul;3(2):103-116. |
·Woo SL, Harris SE, Rosen JM, Chan L, Sperry PJ, Means AR, O'Malley BW.
Use of Sepharose 4B for preparative scale fractionation of eukaryotic messenger RNA's.
Prep Biochem. 1974;4(6):555-572. |
·Liarakos CD, Rosen JM, O'Malley BW.
Effect of estrogen on gene expression in the chick oviduct. II. Transcription of chick tritiated unique deoxyribonucleic acid as measured by hybridization in ribonucleic acid excess.
Biochemistry. 1973 Jul 17;12(15):2809-2816. [PDF] |
·Rosen JM, Liarakos CD, O'Malley BW.
Effect of estrogen on gene expression in the chick oviduct. I. Deoxyribonucleic acid--deoxyribonucleic acid renaturation studies.
Biochemistry. 1973 Jul 17;12(15):2803-2809. [PDF] |
·Wang JJ, Chervinsky DS, Rosen JM.
Comparative biochemical studies of adriamycin and daunomycin in leukemic cells.
Cancer Res. 1972 Mar;32(3):511-515. |
·Rosen JM, Fina JJ, Milholland RJ, Rosen F.
Inhibitory effect of cortisol in vitro on 2-deoxyglucose uptake and RNA and protein metabolism in lymphosarcoma P1798.
Cancer Res. 1972 Feb;32(2):350-355. |
·Rosen JM, Milholland RJ, Rosen F.
A comparison of the effect of glucocorticoids on glucose uptake and hexokinase activity in lymphosarcoma P1798.
Biochim Biophys Acta. 1970 Dec 1;219(2):447-454. |
·Rosen JM, Fina JR, Milholland J, Rosen F.
Inhibition of glucose uptake in lymphosarcoma P1798 by cortisol and its relationship to the biosynthesis of deoxyribonucleic acid.
J Biol Chem. 1970 Apr 25;245(8):2074-2080. [PDF] |
·Rosen JM, Rosen F, Milholland RJ, Nichol CA.
Effects of cortisol on DNA metabolism in the sensitive and resistant lines of mouse lymphoma P1798.
Cancer Res. 1970 Apr;30(4):1129-1136. |
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