| PROJECT DESCRIPTION:
A primary focus of the laboratory is to understand the functions of both systemic hormones and local growth factors in mammary gland development and determine how aberrant regulation of these factors contributes to tumor development and breast cancer. Members of the fibroblast growth factor (Fgf) family and the Fgf receptors (FGFR) have been implicated in mediating various aspects of mammary gland development. Studies of transgenic mice expressing an inducibly active FGFR2 (iFGFR2) have shown that increased activation of FGFR2 results in increased lateral budding along the ductal epithelium and the appearance of lesions. In addition, transgenic mice that express a dominant negative isoform of FGFR, FGFR2IIIb, exhibit decreased alevolar development. Therefore, it is likely that FGFR2 may be an important mediator of mammary gland development.
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PUBLICATIONS:
Schwertfeger K, Xian W, Burnett SH, Kaplan AM, Cohen DA, and Rosen JM
A Critical Role for the Inflammatory Response in a Mouse Model of Breast Cancer Progression.
Cancer Res. 2006; 66: (11) 5676-5685. [PDF] [Supp. Fig] [Sup. Table 1] [Sup. Table 2]
Xian W, Schwertfeger KL, Vargo-Gogola T, Rosen JM.
Pleiotropic effects of FGFR1 on cell proliferation, survival and migration in a 3D mammary epithelial cell model
J Cell Biol, 2005 Nov 21; 171(4): 663-673 [PDF]
Schwertfeger KL, McManaman JL, Palmer CA, Neville MC, Anderson SM.
Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation.
J Lipid Res. 2003 Jun;44(6):1100-12.
Schwertfeger KL, Richert MM, Anderson SM.
Mammary gland involution is delayed by activated Akt in transgenic mice.
Mol Endocrinol. 2001 Jun;15(6):867-81.
Richert MM, Schwertfeger KL, Ryder JW, Anderson SM.
An atlas of mouse mammary gland development.
J Mammary Gland Biol Neoplasia. 2000 Apr;5(2):227-41. Review.
Schwertfeger KL, Hunter S, Heasley LE, Levresse V, Leon RP, DeGregori J, Anderson SM.
Prolactin stimulates activation of c-jun N-terminal kinase (JNK).
Mol Endocrinol. 2000 Oct;14(10):1592-602.
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