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Molecular Endocrinology Cover 2000
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·Seagroves TN, Lydon JP, Hovey RC, Vonderhaar BK, Rosen JM.
C/EBPbeta (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development.
Mol Endocrinol. 2000 Mar;14(3):359-68. [PDF]
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About the Cover: During normal ductal morphogenesis in the mammary gland, a heterogeneous, non-uniform pattern of progesterone receptor expression is established, which appears to be required for the maximal proliferative response to steroid hormones observed during early pregnancy. A more uniform pattern of PR expression coupled with a marked decrease in the number of proliferating cells is observed in C/EBPß knockout mice. In this cover illustration, the background illustrates that progesterone receptor-positive cells (stained with Texas Red) rarely colocalize with proliferative cells (BrdU-positive, stained green with FITC) in the normal mammary ducts as revealed by confocal microscopy (kindly provided by Alejandro Contreras). A reconstruction of 30 digitally merged 1 µm sections from a mammary gland of a 2-day estrogen and progesterone-treated mouse is shown. The foreground depicts a model to explain the use of a juxtacrine signaling mechanism regulating steroid hormone-induced cell proliferation in the normal mammary gland and the proposed switch to an autocrine pathway that may occur in breast cancer.
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