Klotman Lab: Studying HIV in the Kidney
A specialist in nephrology, Dr. Klotman's research focuses on molecular virology and AIDS pathogenesis. He is known throughout the world for his studies of HIV in the kidney, exploring the mechanisms by which HIV induces renal disease.
He developed the first small animal model of HIV-associated nephropathy (HIVAN) using transgenic techniques and his laboratory was the first to demonstrate that HIV directly causes this kidney disorder. His team also found that HIV can be found in human kidney tissue, that the kidney is a reservoir for replicating virus and that the renal tissue serves as a compartment distinct from peripheral blood.
Dr. Klotman has used genomic strategies to identify genes that respond to HIV-1 in the kidney, many of which are novel candidates for the development of renal disease in general.
He is the author of more than 200 scientific publications and has presented his work in the field of HIV pathogenesis internationally. Dr. Klotman has been elected to both the American Society of Clinical Investigation and the Association of American Physicians. He is on the editorial boards of medical journals in the United States and Europe. He has served on and chaired numerous study sections including those from the NIH, the American Heart Association, the National Kidney Foundation and the Veterans Administration research service.
He currently leads the Association of Professors of Medicine's efforts in improving the training and mentoring of physician scientists.