Choose unrestrained whole body plethysmography (uWBP) for high throughput studies on conscious subjects. Systems can be configured for one to several chambers (one subject per chamber). Subjects can move freely in the chambers for minimum stress and study under the most natural conditions.
Buxco's systems include the most modern plethysmograph chambers, utilizing our patented Halcyon ™ pneumotachographs for the quietest baselines available. Each chamber is equipped with a port for aerosol delivery or temperature and humidity measurement, a water bottle port, and a gas sampling port. Tower configuration or urine collection bases are optional.
The uWBP application involves measuring a "box flow" which is the net (or sum) of nasal and thoracic flows. Actual flows are calculated in the software, taking into account temperature, humidity, and pressure.
Buxco's unrestrained uWBP systems are often specified for asthma studies using the enhanced pause ( Penh ) index of airway hyper-reactivity as an indicator of changes in airway resistance. With temperature and humidity compensation and when the subject is not bronchoconstricted, these chambers are suitable for monitoring basic flow derived parameters – respiratory rate, tidal volume, peak flows, and pauses.
Add a gas analyzer to monitor metabolism . Combine with telemetry to measure cardiovascular parameters or lung resistance on conscious subjects .
Key benefits
- Study subjects free from the effects of anesthesia
- Comfortable environment – no restrainer stress
- Study the same subjects repeatedly over days, weeks, and months
- Study subjects for long periods of time – several hours, even days
- Study several subjects simultaneously
- Expose subjects to aerosols or custom gasses in situ
- Minimal preparation required
- Combine with other measurements
Reported parameters
- Enhanced pause (Penh)
- Breath frequency
- Tidal volume
- Total volume breathed
- Minute ventilation
- Inspiratory time
- Expiratory time
- Peak inspiratory flow
- Peak expiratory flow
- End inspiratory pause
- End expiratory pause
- Relaxation time
More information at:
http://www.buxco.com/Pulmonary.aspx?Page=UWBP
|
