Yuxin Fan, M.D., Ph.D.
Assistant Professor, Pediatrics (Cardiology)
Laboratory Director, John Welsh Cardiovascular Diagnostic Laboratory
Education
- M.B. 1987 Anhui College of Traditional Chinese Medicine, Anhui, China
- Ph.D. 1999 Fudan University, Shanghai, China
- Fellowship 2003-2006 University of Washington, Seattle
Board Certifications
American Board of Medical Genetics
Research Interests
As Laboratory Director of the John Welsh Cardiovascular Diagnostics Laboratory, Dr. Fan’s major interests focus on the development and implementation of diagnostic tests for acquired and genetic forms of cardiac disease.
Currently, the laboratory is offering screening for viruses associated with myocarditis and cardiac transplant rejection. The laboratory is also continually expanding its range of molecular diagnostic tests for genetic forms of cardiac disease including Marfan syndrome, Loeys-Dietz syndrome, familial thoracic aortic aneurysm, Barth syndrome, dilated or hypertrophic cardiomyopathy, left ventricular noncompaction, congenital heart diseases, long QT Syndrome, arrhythmia disorders, arrhythmogenic right ventricular dysplasia/cardiomyopathy, etc.
In order to explore the mechanisms behind genetic heart diseases and to develop new treatments, Dr. Fan is also interested in investigating the underlying genetic mechanisms of dilated cardiomyopathy, Marfan syndrome, Loeys-Dietz syndrome, familial thoracic aortic aneurysm, and arrhythmogenic right ventricular dysplasia/cardiomyopathy.
Select Publications
- Linardopoulou E, Williams E, Fan Y, Friedman C, Young J, Trask BJ. Human subtelomeres: hot spots of inter-chromosomal segmental duplication and gene conversion. Nature. 2005;437:94-100.
- Palhan VB, Chen S, Peng GH, Tjernberg A, Gamper AM, Fan Y, Chait BT, La Spada AR, Roeder RG. Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. PNAS. 2005;102:8472-7.
- Fan Y, Limprasert P, Murray IVJ, Smith AC, Lee VM-Y, Trojanowski JQ, Sopher BL, La Spada AR. b-Synuclein modulates a-synuclein neurotoxicity by reducing a-synuclein protein expression. Hum Mol Genet. 2006 Oct 15;15(20):3002-11.
Contact Information
Address:
Section of Cardiology
Department of Pediatrics
Baylor College of Medicine, Feigin Center
1102 Bates Avenue, Suite 430.09
Houston, TX 77030
Phone:
832-824-4155
Fax: 832-825-5159
E-mail: yuxinf@bcm.edu