Daniel G. Rosen, M.D.
Chief Resident
dgrosen@bcm.edu
PGY-III
Med School: Facultad de Medicina, Universidad de Buenos Aires, Argentina
Area of Interest (research or clinical): Surgical pathology, gynecological malignancies, ovarian carcinoma, Translational cancer research.
Professional interests: General interest in the field of surgical pathology with special interest in OB/GYN.
Honors and Awards: Bunge & Born Scholarship (1998), H.E.R.A. foundation trainee award (2006), Delegate to the College of American Pathologists' Residents Forum from Texas and Baylor College of Medicine (2007-2009), House staff representative for Baylor College of Medicine Graduate Medical Education Committee (2007-2008).
Representative publications:
Rosen DG , Huang X, Deavers MT, Malpica A, Silva EG, Liu J. Validation of tissue microarray technology in ovarian carcinoma. Mod Pathol. 2004 Jul;17(7):790-7.
Cai KQ, Albarracin C, Rosen D , Zhong R, Zheng W, Luthra R, Broaddus R, Liu J. Microsatellite instability and alteration of the expression of hMLH1 and hMSH2 in ovarian clear cell carcinoma. Hum Pathol. 2004 May;35(5):552-9.
Yoshida H, Cheng W, Hung J, Montell D, Geisbrecht E, Rosen D , Liu J, Naora H. Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer. Proc Natl Acad Sci U S A. 2004 May 25;101(21):8144-9. Epub 2004 May 14.
Yakupoglu U, Baranowska-Daca E, Rosen D , Barrios R, Suki WN, Truong LD. Post-transplant nephrotic syndrome: A comprehensive clinicopathologic study. Kidney Int. 2004 Jun;65(6):2360-70.
Lu KH, Patterson AP, Wang L, Marquez RT, Atkinson EN, Baggerly KA, Ramoth LR, Rosen DG , Liu J, Hellstrom I, Smith D, Hartmann L, Fishman D, Berchuck A, Schmandt R, Whitaker R, Gershenson DM, Mills GB, Bast RC Jr. Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis. Clin Cancer Res. 2004 May 15;10(10):3291-300.
Baykal A, Rosen D , Zhou C, Liu J, Sahin AA. Telomerase in breast cancer: a critical evaluation. Adv Anat Pathol. 2004 Sep;11(5):262-8. Review.
Rosen DG , Wang L, Jain AN, Lu KH, Luo RZ, Yu Y, Liu J, Bast RC Jr. Expression of the tumor suppressor gene ARHI in epithelial ovarian cancer is associated with increased expression of p21WAF1/CIP1 and prolonged progression-free survival. Clin Cancer Res. 2004 Oct 1;10(19):6559-66.
Rosen DG , Yang G, Cai KQ, Bast RC Jr, Gershenson DM, Silva EG, Liu J. Subcellular localization of p27kip1 expression predicts poor prognosis in human ovarian cancer. Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):632-7.
Lee P, Rosen DG , Zhu C, Silva EG, Liu J. Expression of progesterone receptor is a favorable prognostic marker in ovarian cancer. Gynecol Oncol. 2005 Mar;96(3):671-7.
Cheng W, Liu J, Yoshida H, Rosen D , Naora H. Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract. Nat Med. 2005 May;11(5):531-7. Epub 2005 Apr 10.
Ramanathan V, Suki WN, Rosen D , Truong LD. Chronic allograft nephropathy and nephrotic range proteinuria. Clin Transplant. 2005 Jun;19(3):413-7.
Nunez MI, Rosen DG , Ludes-Meyers JH, Abba MC, Kil H, Page R, Klein-Szanto AJ, Godwin AK, Liu J, Mills GB, Aldaz CM. WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome. BMC Cancer. 2005 Jun 27;5(1):64.
Rosen DG , Wang L, Atkinson JN, Yu Y, Lu KH, Diamandis EP, Hellstrom I, Mok SC, Liu J, Bast RC Jr. Potential markers that complement expression of CA125 in epithelial ovarian cancer. Gynecol Oncol. 2005 Nov;99(2):267-77. Epub 2005 Aug 2.
Eder AM, Sui X, Rosen DG , Nolden LK, Cheng KW, Lahad JP, Kango-Singh M, Lu KH, Warneke CL, Atkinson EN, Bedrosian I, Keyomarsi K, Kuo WL, Gray JW, Yin JC, Liu J, Halder G, Mills GB. Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12519-24. Epub 2005 Aug 22.
Hu Y, Rosen DG , Zhou Y, Feng L, Yang G, Liu J, Huang P. Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. J Biol Chem. 2005 Nov 25;280(47):39485-92. Epub 2005 Sep 22.
Yoshida H, Liu J, Samuel S, Cheng W, Rosen D , Naora H. Steroid receptor coactivator-3, a homolog of Taiman that controls cell migration in the Drosophila ovary, regulates migration of human ovarian cancer cells. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):77-85. Epub 2005 Nov 18.
Rosen DG , Yang G, Deavers MT, Malpica A, Kavanagh JJ, Mills GB, Liu J. Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma. Cancer. 2006 May 1;106(9):1925-32.
Lu Z, Luo RZ, Peng H, Rosen DG , Atkinson EN, Warneke C, Huang M, Nishmoto A, Liu J, Liao WS, Yu Y, Bast RC Jr. Transcriptional and posttranscriptional down-regulation of the imprinted tumor suppressor gene ARHI (DRAS3) in ovarian cancer. Clin Cancer Res. 2006 Apr 15;12(8):2404-13.
Wang H, Rosen DG , Wang H, Fuller GN, Zhang W, Liu J. Insulin-like growth factor-binding protein 2 and 5 are differentially regulated in ovarian cancer of different histologic types. Mod Pathol. 2006 Sep;19(9):1149-56. Epub 2006 May 26.
Yu Y, Luo R, Lu Z, Wei Feng W, Badgwell D, Issa JP, Rosen DG , Liu J, Bast RC Jr. Biochemistry and Biology of ARHI (DIRAS3), an Imprinted Tumor Suppressor Gene Whose Expression Is Lost in Ovarian and Breast Cancers. Methods Enzymol. 2005;407:455-68.
Rosen DG , Yang G, Bast RC Jr, Liu J. Use of ras-transformed human ovarian surface epithelial cells as a model for studying ovarian cancer. Methods Enzymol. 2005;407:660-76.
Zhang Z, Rosen DG , Yao JL, Huang J, Liu J. Expression of p14ARF, p15INK4b, p16INK4a, and DCR2 increases during prostate cancer progression. Mod Pathol. 2006 Oct;19(10):1339-43. Epub 2006 Jun 23.
Yang G, Rosen DG , Mercado-Uribe I, Colacino JA, Mills GB, Bast RC Jr, Zhou C, Liu J. Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells.
Carcinogenesis. 2007 Jan;28(1):174-82. Epub 2006 Jul 8.
Rosen DG , Cai KQ, Luthra R, Liu J. Immunohistochemical staining of hMLH1 and hMSH2 reflects microsatellite instability status in ovarian carcinoma. Mod Pathol. 2006 Nov;19(11):1414-20. Epub 2006 Aug 25.
Yang G, Rosen DG , Colacino JA, Mercado-Uribe I, Liu J. Disruption of the retinoblastoma pathway by small interfering RNA and ectopic expression of the catalytic subunit of telomerase lead to immortalization of human ovarian surface epithelial cells. Oncogene. 2007 Mar 1;26(10):1492-8. Epub 2006 Sep 4.
Wang-Johanning F, Liu J, Rycaj K, Huang M, Tsai K, Rosen DG , Chen DT, Lu DW, Barnhart KF, Johanning GL. Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer. Int J Cancer. 2007 Jan 1;120(1):81-90.
Yang G, Rosen DG , Zhang Z, Bast RC Jr, Mills GB, Colacino JA, Mercado-Uribe I, Liu J. The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16472-7. Epub 2006 Oct 23.
Rosen DG , Mercado-Uribe I, Yang G, Bast RC Jr, Amin HM, Lai R, Liu J. The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis. Cancer. 2006 Dec 1;107(11):2730-40.
Young TW, Mei FC, Rosen DG , Yang G, Li N, Liu J, Cheng X. Up-regulation of tumor susceptibility gene 101 protein in ovarian carcinomas revealed by proteomics analyses. Mol Cell Proteomics. 2007 Feb;6(2):294-304. Epub 2006 Nov 16.
Young TW, Rosen DG , Mei FC, Li N, Liu J, Wang XF, Cheng X. Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer. Clin Cancer Res. 2007 Jul 1;13(13):3848-54.
Feng W, Xiao J, Zhang Z, Rosen DG , Brown RE, Liu J, Duan X. Senescence and apoptosis in carcinogenesis of cervical squamous carcinoma. Mod Pathol. 2007 Sep;20(9):961-6. Epub 2007 Jul 13.
Zhang Z, Singh M, Davidson S, Rosen DG , Yang G, Liu J. Activation of BTAK expression in primary ovarian surface epithelial cells of prophylactic ovaries. Mod Pathol. 2007 Oct;20(10):1078-84. Epub 2007 Aug 3.
Feng W, Shen L, Wen S, Rosen DG , Jelinek J, Hu X, Huan S, Huang M, Liu J, Sahin AA, Hunt KK, Bast RC Jr, Shen Y, Issa JP, Yu Y. Correlation between CpG methylation profiles and hormone receptor status in breast cancers. Breast Cancer Res. 2007 Aug 31;9(4):R57.