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Pathology

Houston, Texas

Department of Pathology
Pathology
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Faculty

Mamoun Younes, M.D. Professor

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Education

  • Aleppo University Faculty of Medicine, Aleppo Syria (M.D.)

Internship

  • Tartous National Hospital, Tarous, Syria

Residency

  • Anatomic Pathology, Yale University School of Medicine, New Haven, CT

Fellowship

  • Visiting Fellow, Digestive Diseases Branch, NIDDK, NIH, Bethesda, MD

  • Gastrointestinal Pathology Fellowship, Baylor College of Medicine, Houston, TX

Specialty

  • Gastrointestinal Pathology

Board Certification

  • Anatomic Pathology

Area of Interest

  • Gastrointestinal pathology

  • immunohistochemistry

  • predictive markers

  • Barrett's metaplasia (Barrett's esophagus)

  • premalignant conditions

  • gastrointestinal cancers

Current Position

  • Professor (tenured), Department of Pathology

  • Professor (tenured), Department of Medicine (Gastroenterology)

Professional Positions Held

  • Director, Gastrointestinal Pathology Service

  • Director, Laboratory of Diagnostic and Predictive Markers

Other Positions

  • Director, Gastrointestinal Pathology Fellowship Program

Honors and Awards

  • The W. L. Moody, Jr. Chair in Pathology

  • "Poster of Distinction", Digestive Diseases Week, Chicago, IL, May 2005. Selected by the American Gastroenterological Association (AGA) Council

  • "Best Poster at the 9th International Congress on Breast Diseases Award" from the American Society of Breast Disease, 1996

  • American College of Gastroenterology Governors Award for Excellence in Clinical Research, Best Scientific Paper at the 1996 Annual Scientific Meeting

  • American College of Gastroenterology Governors Award for Excellence in Clinical Research, Best Scientific Paper at the 1997 Annual Scientific Meeting

  • Totten Visiting Professor, Department of Pathology, University of Pittsburgh, Pittsburgh, PA

  • Elected by peers to "Best Doctors in America", 2005-2008

  • "America's Top Physicians" 2005-2008

  • Elected Fellow of the American Gastroenterological Association (AGAF), May 2007

Membership on professional organizations

  • Houston Society of Clinical Pathologists, 1992-present

  • United States and Canadian Academy of Pathology (formerly IAP), 1992-present

  • Gastrointestinal Pathology Society, 1992-present

  • College of American Pathologists, 1993-present

  • American Association for Cancer Research, 1993-present

  • American College of Gastroenterology, 1997-present

  • American Gastroenterological Association, 1999-present

  • Harris County Medical Society, 2002-present

  • Arthur Purdy Stout Society of Surgical Pathologists, 2002-present

  • American Society of Clinical Oncology, 2004-present

Representative Publications

  1. Honma N, Horil R, Iwase T, Saji S, Younes M , Takubo K, Matsuura M, Ito Y, Akiyama F, Sakamoto G. Clinical importance of estrogen receptor-beta evaluation in breast cancer patients treated with adjuvant tamoxifen therapy. J Clin Oncol 2008 (in press)
  2. Younes M, Ertan A, Ergun G, Verm R, Bridges M, Woods K, Meriano F, Schmulen C, Colman R, Johnson C, Barroso A, Schwartz J, Ball D, McKechnie J, Lechago J. Goblet cell mimickers in esophageal biopsies are not associated with an increased risk for dysplasia. Arch Pathol Lab Med 2007; 131:571-575
  3. Younes M, Georgakis GV, Rahmani M, Beer D, Younes A. Functional Expression of TRAIL Receptors TRAIL-R1 and TRAIL-R2 in Esophageal Adenocarcinoma. Eur J Cancer 2006; 42:542-547
  4. Younes M. Frozen Section of the Gastrointestinal Tract, Appendix and Peritoneum (Review). Arch Pathol Lab Med. 2005; 129:1558-1564
  5. Chen X, Lechago J, Ertan A, Ergun G, Verm R, Bridges M, Johnson C, Woods K, Meriano F, Chirala M, Younes M. Expression of High Mobility Group proteins HMGI(Y) correlates with malignant progression in Barrett's metaplasia. Cancer Epidemiol Biomarkers & Preven 2004; 13:30-33
  6. Liu L, Ergun G, Ertan A, Woods K, Sachs I, Younes M. Detection of oxidative DNA damage in oesophageal biopsies of patients with reflux symptoms and normal pH monitoring. Aliment Pharmacol Ther 2003; 18:693-698
  7. Yorke R, Younes A, Chirala M, Younes M. Receptor activator of nuclear factor kappaB (RANK) is expressed as a late event during malignant progression in Barrett's metaplasia. European J Cancer 2003; 39:2099-2102
  8. Younes M, Henson DE, Ertan A, Miller CC. Incidence and survival trends of esophageal carcinoma in the United States: racial and gender differences by histological type. Scand J Gastroenterol 2002; 37:1359-1365
  9. Witte D, Chirala M, Younes A, Li Y, Younes M. Estrogen receptor beta is expressed in human colorectal adenocarcinoma. Hum Pathol 2001; 32:940-944
  10. Mann S, Laucirica R, Carlson N, Younes PS, Ali N, Younes A, Li Y, and Younes M. Estrogen receptor beta expression in invasive breast cancer. Hum Pathol 2001; 32:113-118
  11. Younes M, Schwartz MR, Ertan A, Finnie D, Younes A. Fas Ligand expression in esophageal carcinomas and their lymph node metastases. Cancer 2000; 88:524-528
  12. Younes M, Brown RW, Stephenson M, Gondo M, Cagle PT. Overexpression of Glut1 and Glut3 in stage I non-small cell lung carcinoma is associated with worse survival. Cancer 1997; 89:1046-1051
  13. Younes M, Ertan A, Lechago LV, Somoano JR, Lechago JL. The human erythrocyte glucose transporter (Glut1) is immunohistochemically detected as a late event during malignant progression in Barrett's metaplasia. Cancer Epidemiol, Biomarkers, and Prev 1997; 6:303-305
  14. Younes M, Ertan A, Lechago LV, Somoano JR, Lechago JL. p53 protein accumulation is a specific marker of malignant potential in Barrett's metaplasia. Digest Dis Sci 1997; 42:697-701
  15. Younes M, Lechago LV, Lechago J. Overexpression of the human erythrocyte glucose transporter is a late event in human colorectal carcinogenesis, and is associated with an increased incidence of lymph node metastases. Clin Cancer Res 1996; 2:1151-1154
  16. Younes M, Lechago LV, Somoano JR, Mosharaf M, Lechago J. Wide expression of the human erythrocyte glucose transporter Glut1 in benign and malignant human tissues. Cancer Res 1996; 56:1164-1167
  17. Younes M, Lebovitz R, Lechago L, Lechago J. p53 protein accumulation in Barrett's metaplasia, dysplasia, and carcinoma: A follow-up study. Gastroenterology 1993; 105: 1637-1642