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Pathology

Houston, Texas

Department of Pathology
Pathology
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Faculty

Nikolai A Timchenko, Ph.D. Professor of Pathology

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Education

  • Ph.D.

Specialty

  • Molecular Biology

  • Biochemistry

Area of Interest

  • Research

Current Position

  • Professor

Professional Positions Held

  • Professor, Pathology Department, Baylor College of Medicine, Houston, Texas, May 2007-Present

  • Associate Professor, Pathology Department, Baylor College of Medicine, Houston, Texas, 2002-April 2007

  • Assistant Professor, Pathology Department, Baylor College of Medicine, Houston, Texas, 1995-2002

Honors and Awards

  • Michael E. DeBakey, M.D. Excellence in Research Award November 10, 2004

Membership on professional organizations

  • American Society for Biochemistry and Molecular Biology

Representative Publications

  1. Wang, G-L., Salisbury , E., Shi, X., Timchenko, L. T., Medrano, E.E. Timchenko, N.A. HDAC1 PROMOTES LIVER PROLIFERATION IN YOUNG MICE VIA INTERACTIONS WITH C/EBP b . JBC papers in press. Published on line, July11, 2008.
  2. Wang, G-L., Salisbury , E., Shi, X., Timchenko, L. T., Medrano, E.E. Timchenko, N.A. HDAC1 COOPERATES WITH C/EBP a IN THE INHIBITION OF LIVER PROLIFERATION IN OLD MICE.  2008. JBC papers in press. Published on line, July11, 2008.
  3. Wang, G-L., Shi, X, Salisbury E., Timchenko N.A. Regulation of apoptotic and growth inhibitory activities of C/EBP a in different cell lines. Exp. Cell Research, 2008, 314:1626-1639.
  4. Smith, RG, Sun, Y, Jiang, H, Alabarran-Zechler, R and Timchenko, N.A. Ghrelin receptor (GHS-R1A) Agonists show potential as interventive agents during aging. Ann. New York Acad. Sci. 2007, 1119:147-164.
  5. Harrison-Findik, D.D., Klein, E, Crist, C., Evans, J. Timchenko, N. A., Gollan, J. Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol. Hepatology, 2007, 46:1979-1985. 
  6. Bandyopadhyay, B., Curry, J. L., Lin Quishi, Richards, H, W., Chen, D., Hornsby, P., Timchenko, N. A. Medrano E. E. Dynamic Assembly of Chromatin during Cellular Senescence: Implications for the Growth Arrest of Human Melonocytic Nevi. Aging Cell, 2007, 6: 577-591. 
  7. Huichalaf, C. H., Sakai , K., Wang, G-L., Timchenko, N.A., and Timchenko, L. T. Regulation of the promoter of CUG triplet repeat binding protein, Cugbp1, during myogenesis . Gene 2007, 396:391-402.
  8. Wang, G-L, Shi, X., Salisbury , E., Sun, Y., Albrecht, J. H, Smith, R. Timchenko, N.A.    Growth Hormone Corrects Proliferation and Transcription of PEPCK in Livers of Old Mice via Elimination of C/EBP a -Brm Complex. J. Biol Chem. 2007, 282:1468-1478.
  9. Timchenko L. T., Salisbury, E., Wang, G-L., Nguyen, H-D., Albrecht, J.H., Hershey, J. W.B. and Timchenko, N.A. Age-specific CUGBP1-eIF2 complex increases translation of C/EBPα in old liver. J Biol Chem 2006, in press
  10. Karagiannides, I., Thomou, T., Tchkonia, T., Pirtkalava, Y., Kypreos, K.E., Cartwright, A., Dalageorgou, G., Lash, T.L., Farmer, S R., Timchenko, N.A., Kirkland, J.L. Increased CUG triplet repeat binding protein-1 predisposes to impaired adipogenesis with aging. J Biol Chem 2006: 28:23025-23033
  11. Harrison-Findik D.D., Schafer D., Klein E., Timchenko N.A., Kulaksiz, H., Clemens, D., Fein, E., Andriopoulos, K., Gollan J. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J. Biol. Chem 2006:28: 22974-22982
  12. McFie PJ., Wang, G-L, Timchenko, N.A., Wilson H.L., Hu, H., Roesler WJ. Identification of a Co-repressor that inhibits the transcriptional and growth arrest activities of C/EBP?. J. Biol. Chem. 2006:28:18069-18080
  13. Wang, G-L., Shi, X., Salisbury, E., Sun, Y., Albrecht, J.H., Smith, R. G. and Timchenko, N.A. "Cyclin D3 maintains growth-inhibitory activity of C/EBPα by stabilizing C/EBPα-cdk2 and C/EBPβ-Brm complexes". Mol. Cell Biol 26:2570-2582, 2006
  14. Timchenko N.A, Wang, G-L and Timchenko L.T. "CUG triplet repeat binding protein, CUGBP1, increases translation of C/EBPβ isoform, LIP, by interacting with the α and β subunits of eIF2". J. Biol Chem 2005 280: 20549-20557
  15. Wang, G-L. and Timchenko N.A. "Dephosphorylated C/EBPα accelerates cell proliferation through sequestering retinoblastoma protein". Mol Cell Biol. 2005 25, v 4, 1325-1338
  16. Helbling, D., Mueller, B.U., Timchenko N.A., Hagemeiger, A., Jotterand, M., Meyer-Monard, S., Lister, A., Rowley, J.D., Huegli, B., Fey, M.F. and Pabst, T. "The leukemic fusion gene AML1-MDS1-EVI1 suppresses C/EBPA in acute myeloid leukemia by activation of Calreticulin" Proc. Natl. Acad. Sci. USA 2004 101:13312-13317
  17. Wang, G-L, Iakova, P., Wilde, M., Awad, S. and Timchenko N.A. "Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBPα growth inhibitory activity" Gen & Dev 2004 18:912-925
  18. Timchenko, N.A. Patel, R., Iakova, P., Cai Z-J., Quan, L. and Timchenko, L.T. Overexpression of CUG triplet repeat binding protein, CUGBP1, inhibits myogenesis. J. Biol. Chem. 2004 279:13129-13139
  19. Iakova, P., Wang, G-L., Timchenko, L.T., Michalak, M., Pereira-Smith, O., Smith, J.R. and Timchenko, N.A. Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate. EMBO J. 2004 23:406-417
  20. Timchenko N.A. Old livers: C/EBPα meets new partners. Cell Cycle 2003, 2:5, 445-446
  21. Iakova, P., Awad, S.S. and Timchenko N.A. Aging reduces proliferative capacities of liver by switching pathways of C/EBPα growth arrest. Cell 113: 495-506, 2003
  22. Welm, A.L., Timchenko, N.A., Ono, Y., Sorimachi, H., Radomska, H.S., Tenen, D.G., Lekstrom-Himes, J. and Darlington, G.J. C/EBPα is required for proteolytic cleavage of cyclin A by calpain 3 in myeloid precursor cells". J. Biol. Chem. 277:33848-33856, 2002
  23. Timchenko, L.T., Iakova, P., Welm, A., Cai, Z-J. and Timchenko N. A. Calreticulin interacts with C/EBPα and C/EBPβ mRNAs and inhibits translation of C/EBP proteins. Mol Cell Biol. 22:722-7257, 2002