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Pathology

Houston, Texas

Department of Pathology
Pathology
not shown on screen

Faculty

Nikolai A. Timchenko, Ph.D. Professor of Pathology

Nikolai A. Timchenko

Education

  1. Ph.D.

Specialty

  1. Molecular Biology

  2. Biochemistry

Area of Interest

  1. Research

Current Position

  1. Professor

Professional Positions Held

  1. Professor, Pathology Department, Baylor College of Medicine, Houston, Texas, May 2007-Present

  2. Associate Professor, Pathology Department, Baylor College of Medicine, Houston, Texas, 2002-April 2007

  3. Assistant Professor, Pathology Department, Baylor College of Medicine, Houston, Texas, 1995-2002

Honors and Awards

  1. Michael E. DeBakey, M.D. Excellence in Research Award November 10, 2004

Membership on professional organizations

  1. American Society for Biochemistry and Molecular Biology

Representative Publications

  1. Wang, G-L., Salisbury , E., Shi, X., Timchenko, L. T., Medrano, E.E. Timchenko, N.A. HDAC1 PROMOTES LIVER PROLIFERATION IN YOUNG MICE VIA INTERACTIONS WITH C/EBP b . JBC papers in press. Published on line, July11, 2008.

  2. Wang, G-L., Salisbury , E., Shi, X., Timchenko, L. T., Medrano, E.E. Timchenko, N.A. HDAC1 COOPERATES WITH C/EBP a IN THE INHIBITION OF LIVER PROLIFERATION IN OLD MICE.  2008. JBC papers in press. Published on line, July11, 2008.

  3. Wang, G-L., Shi, X, Salisbury E., Timchenko N.A. Regulation of apoptotic and growth inhibitory activities of C/EBP a in different cell lines. Exp. Cell Research, 2008, 314:1626-1639.

  4. Smith, RG, Sun, Y, Jiang, H, Alabarran-Zechler, R and Timchenko, N.A. Ghrelin receptor (GHS-R1A) Agonists show potential as interventive agents during aging. Ann. New York Acad. Sci. 2007, 1119:147-164.

  5. Harrison-Findik, D.D., Klein, E, Crist, C., Evans, J. Timchenko, N. A., Gollan, J. Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol. Hepatology, 2007, 46:1979-1985. 

  6. Bandyopadhyay, B., Curry, J. L., Lin Quishi, Richards, H, W., Chen, D., Hornsby, P., Timchenko, N. A. Medrano E. E. Dynamic Assembly of Chromatin during Cellular Senescence: Implications for the Growth Arrest of Human Melonocytic Nevi. Aging Cell, 2007, 6: 577-591. 

  7. Huichalaf, C. H., Sakai , K., Wang, G-L., Timchenko, N.A., and Timchenko, L. T. Regulation of the promoter of CUG triplet repeat binding protein, Cugbp1, during myogenesis . Gene 2007, 396:391-402.

  8. Wang, G-L, Shi, X., Salisbury , E., Sun, Y., Albrecht, J. H, Smith, R. Timchenko, N.A.    Growth Hormone Corrects Proliferation and Transcription of PEPCK in Livers of Old Mice via Elimination of C/EBP a -Brm Complex. J. Biol Chem. 2007, 282:1468-1478.

  9. Timchenko L. T., Salisbury, E., Wang, G-L., Nguyen, H-D., Albrecht, J.H., Hershey, J. W.B. and Timchenko, N.A. Age-specific CUGBP1-eIF2 complex increases translation of C/EBPα in old liver. J Biol Chem 2006, in press

  10. Karagiannides, I., Thomou, T., Tchkonia, T., Pirtkalava, Y., Kypreos, K.E., Cartwright, A., Dalageorgou, G., Lash, T.L., Farmer, S R., Timchenko, N.A., Kirkland, J.L. Increased CUG triplet repeat binding protein-1 predisposes to impaired adipogenesis with aging. J Biol Chem 2006: 28:23025-23033

  11. Harrison-Findik D.D., Schafer D., Klein E., Timchenko N.A., Kulaksiz, H., Clemens, D., Fein, E., Andriopoulos, K., Gollan J. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J. Biol. Chem 2006:28: 22974-22982

  12. McFie PJ., Wang, G-L, Timchenko, N.A., Wilson H.L., Hu, H., Roesler WJ. Identification of a Co-repressor that inhibits the transcriptional and growth arrest activities of C/EBP?. J. Biol. Chem. 2006:28:18069-18080

  13. Wang, G-L., Shi, X., Salisbury, E., Sun, Y., Albrecht, J.H., Smith, R. G. and Timchenko, N.A. "Cyclin D3 maintains growth-inhibitory activity of C/EBPα by stabilizing C/EBPα-cdk2 and C/EBPβ-Brm complexes". Mol. Cell Biol 26:2570-2582, 2006

  14. Timchenko N.A, Wang, G-L and Timchenko L.T. "CUG triplet repeat binding protein, CUGBP1, increases translation of C/EBPβ isoform, LIP, by interacting with the α and β subunits of eIF2". J. Biol Chem 2005 280: 20549-20557

  15. Wang, G-L. and Timchenko N.A. "Dephosphorylated C/EBPα accelerates cell proliferation through sequestering retinoblastoma protein". Mol Cell Biol. 2005 25, v 4, 1325-1338

  16. Helbling, D., Mueller, B.U., Timchenko N.A., Hagemeiger, A., Jotterand, M., Meyer-Monard, S., Lister, A., Rowley, J.D., Huegli, B., Fey, M.F. and Pabst, T. "The leukemic fusion gene AML1-MDS1-EVI1 suppresses C/EBPA in acute myeloid leukemia by activation of Calreticulin" Proc. Natl. Acad. Sci. USA 2004 101:13312-13317

  17. Wang, G-L, Iakova, P., Wilde, M., Awad, S. and Timchenko N.A. "Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBPα growth inhibitory activity" Gen & Dev 2004 18:912-925

  18. Timchenko, N.A. Patel, R., Iakova, P., Cai Z-J., Quan, L. and Timchenko, L.T. Overexpression of CUG triplet repeat binding protein, CUGBP1, inhibits myogenesis. J. Biol. Chem. 2004 279:13129-13139

  19. Iakova, P., Wang, G-L., Timchenko, L.T., Michalak, M., Pereira-Smith, O., Smith, J.R. and Timchenko, N.A. Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate. EMBO J. 2004 23:406-417

  20. Timchenko N.A. Old livers: C/EBPα meets new partners. Cell Cycle 2003, 2:5, 445-446

  21. Iakova, P., Awad, S.S. and Timchenko N.A. Aging reduces proliferative capacities of liver by switching pathways of C/EBPα growth arrest. Cell 113: 495-506, 2003

  22. Welm, A.L., Timchenko, N.A., Ono, Y., Sorimachi, H., Radomska, H.S., Tenen, D.G., Lekstrom-Himes, J. and Darlington, G.J. C/EBPα is required for proteolytic cleavage of cyclin A by calpain 3 in myeloid precursor cells". J. Biol. Chem. 277:33848-33856, 2002

  23. Timchenko, L.T., Iakova, P., Welm, A., Cai, Z-J. and Timchenko N. A. Calreticulin interacts with C/EBPα and C/EBPβ mRNAs and inhibits translation of C/EBP proteins. Mol Cell Biol. 22:722-7257, 2002