Faculty

Education

• M.D. Kunming Medical College , Yunnan , P.R. of China

• Ph.D. in medicine , Department of Medicine, University of Sheffield , U.K.

• M.Sc. in Physiology, Tongji Medical University , P.R. of China

Post-doctoral Training

• Department of Pathology & Molecular Medicine & Biology, McMaster University, Hamilton Regional Cancer Center, Hamilton, Canada (Dec. 1998 - Dec. 2000)

Specialty

• Tissue Banking

• Tissue-Based Services

• Cancer Research

• Molecular Biology

Area of Interest

• Organization of the tissue resources at a Baylor College of Medicine to facilitate the tissue-bases services for researchers

• Cancer research in identifying the disease mechanisms and approaches for cancer therapies

Current Position

• Project Manager of Tissue Banking, Department of Pathology, Baylor College of Medicine

Professional Positions Held

• Project Manager of Tissue Banking (June 2007 to present) , Department of Pathology, Baylor College of Medicine. Take charge of the Cancer Center Tissue Shared Resource as the chief technical administrator with responsibilities that include but not limited to the following: Responsible for organizing staff to constuct tissue microarrays from all of the common cancers at Ben Taub and VAMC for the past 10 years. Responsible for coordinating the archival and prospective tissue resource with the data management division of the DDCC to implement specimen annotation and a mechanism to tract disposition of these resources. Oversee and train individuals responsible for tissue consenting for all cancer cases as Ben Taub and VAMC. Develop an Organizational scheme that more fully integrates all of the sub-banks of the DDCC Tissue Shared Resource. Reports directly to Dr. Wheeler as director of the DDCC Tissue Shared Resource

• Manager of Molecular Biology Service, Senior Scientist, Sales Support, TMA supervisor & QA&QC (Sep. 2001 to Dec. 2006) . Asterand plc. Detroit , MI , USA. Supervised for tissue microarrays (TMAs) project and developed customized assays for various TMA-based service projects. Key player for conducting company's tissue-based service projects. Managed molecular biology service team which consistently met its objective to fulfill customer's requests for high quality molecular products. Developed highly efficient standard operation procedures for both production and services projects

• Research Associate (Mar. 2001 – Sep. 2001) Department of Anatomy and Cell Biology, Wayne State University , Detroit , MI , USA . Project: Proteolipid Protein, a myelin protein, in Regulation in Survival and Differentiation of Oligodendrocytes

• Research Associate (Jan. 1998 – Dec. 1998) Department of Pathology, Division of the Cancer and Oncology, Royal Hallamshire Hospital, University of Sheffield, Sheffield, U.K . P roject: to define regions of CC Chemokine receptor 3 (CCR3) involving in the coupling to G proteins

• Research for my Ph.D. (May. 1994 – Jan. 1998) Department of Endocrinology, St. Bartholomew's Hospital, University of London , London EC1 7BE , U.K. Department of Medicine, Northern General Hospital , University of Sheffield , UK . Project: Variants of the human growth hormone receptor and their regulation

• Research for my M.Sc. (Sep. 1987 – Jul. 1990) Department of Physiology, Tongji Medical University , Wuhan , China . Project: Cardiovascular Regulation in Central Renal Angiotensin System and Catecholamine System

• Lecturer (1992-1993), Assistant lecturer (1985-1987 & 1990-1992) Department of Physiology, Dali Medical College . Dali , Yunnan , China

Honors and Awards

• Received the award for Asterand as the High Technology Company of the Year presented by Michigan state Governor, Jennifer Granholm, on May 20, 2005

• Travel award for best young endocrinologist by British Endocrine Society in 1997

Membership on professional organizations

• British Endocrine Society

• American Association of Cancer Research

Representative Publications

1. Glazyrin A (first author), Shen X (First Author), Blanc V, Eliason JF. Direct detection of herceptin/trastuzumab binding on breast tissue sections. 2007 Jan; 55(1):25-33

2. Shen XY, Zacal N, Singh G, Rainbow AJ. Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT-29 colon carcinoma cells. Photochemistry and Photobiology , 2005 Mar-Apr; 81(2):306-13

3. Auger GA, Pease JE, Shen X, Xanthou G, Barker MD. Alanine scanning mutagenesis of CCR3 reveals that the three intracellular loops are essential for functional receptor expression. Europe Journal of Immunology, 2002 Apr; 32(4):1052-8

4. Singh G, Espiritu M, Shen XY, Hanlon JG, Rainbow AJ. In vitro induction of PDT resistance in HT29, HT1376 and SK-N-MC cells by various photosensitizers. Photochemistry and Photobiology . 2001 Jun; 73 (6):651-6

5. S. Von Laue, S.L, J. Finidori, M Maamra, X.Y.Shen, S. Justice, P. R. M. Dobson, R.J.M. Ross. Stimulation of endogenous GH and IL-6 receptors selectively activates different jaks and stats, with a stat5 specific synergistic effect of dexamethasone. Journal of Endocrinology. 2000 May; 165(2):301-11

6. X.Y. Shen, R. Holt, J.P. Miell, S. Justice, M-C Postel-Vinay, R.J.M. Ross. Cirrhotic liver expresses low levels of the full length and truncated growth hormone receptor. Journal of Clinical Endocrinology and Metabolism 83(7), 2532-2538, 1998

7. R.J.M. Ross, N. Esposito, A. Palizban, X.Y. Shen, S. Von Laue, S.L. Chew, M. Norman, M-C Postel-Vinay, J. Finidori. Variant splicing in the human growth hormone receptor encodes a short isoform which inhibits competitively signal transduction by the full length receptor and generates a binding protein. Molecular Endocrinology 11(3), 265-273, 1997

8. X.Y. Shen, J. Rodriguez-Arnao, R.J.M. Ross. Regulation of hepatic mRNA levels for the growth hormone receptor in rats with altered thyroid status. Growth Regulation 5, 199-202, 1995

9. J. Deng, H. Ding, Z.Y. Wu, Q. Wang, X.Y. Shen and K. Yang. Effect of intracerebroventricular injection of 6-hydroxydopamine on the peripheral catecholamine and angiotensin II in SHR. Journal of Tongji Medical University , 13 (4), 202-205, 1993

10. X.Y. Shen, Q. Wang, K. Yang. Effects of central RAS on one-kidney Grollman hypertension in rats and its mechanism. Journal of Tongji Medical University , 11 (1), 31-35, 1991

11. K. Yang, X.Y. Shen and Q. Wang. Investigation on the role of central catecholamine and angiotensin II in one-kidney Grollman hypertension in rats. Chinese Journal of Pathophysiology, 8 (2), 192-194, 1991

12. Q. Wang Qing, X.Y. Shen, K.Yang. Brain catecholamine in one-kidney Grollman hypertensive rats. Chinese Journal of Physiology Sciences, 7 (2), 176-180, 1991

13. Alexey Glazyrin (first author), Xiaoyun Shen (First Author), Victoria Blanc and James F. Eliason A novel, highly sensitive immunohistochemistry assy for her2/neu expression on breast cancer cells using the drug herceptin TM . Clinical Cancer Research. 9046s. 2006

14. Samir Alhasan, Xiaoyun Shen, George Azrak, James F. Eliason. Asterand, Inc., Detroit , MI. Analysis of RNA quality and yields of frozen samples in a large research repository, American Association for Cancer Research, Washington , DC , 2006

15. Ed Luther, William Geddie, Xiaoyun Shen, Alexey Glazyrin and James Eliason Analysis of Chromatically Stained Tissues and TMA's by Laser Scanning Cytometry. American Association for Cancer Research, 2005

16. Bovenschen N., Quadir R., Broekhuizen R., Chang W., Shen, X . and Kummer, J.A Development of SERPINB13 specific monoclonal antibodies and the distribution in normal tissues and malignancy. SERPINS 2005. Palm Cove , Australia . 6-10 June, 2005

17. Samir A. Alhasan, Xiaoyun Shen Masuod Ahmadalmehrabi, Kimberly Reed, and James F. Eliason. Tissue microarrays a high-throughput approach for analyzing molecular marker expression in archival cancer specimens using immnohistochemistry. American Association Cancer Research, April, 2003. ( Toronto , Canada )

18. XY Shen, M Espiritu, A J Rainbow, G Singh, Increased BNIP3 expression in photodynamic therapy resistant variants of HT29. American Association Cancer Research, April, 2000. ( San Francisco , USA )

19. X.Y. Shen, V.L. Singward, S. Justice, R.J.M. Ross. A stable clone of growth hormone receptor (GHR) in HepG 2 cells as model for GHR signalling studies. 16th Joint Meeting of British Endocrinology Societies, March, 1997. ( Harrogate , UK )

20. X.Y. Shen, J. Pell, R.J.M Ross. Expression of insulin-like growth factor-I (IGF-I) mRMA in IM-9 cells and regulation by growth hormone (GH) in starved and fed state. 15th Joint Meeting of British Endocrinology Societies, March 1996. ( Dublin , Ireland )

21. X.Y. Shen, J. Rodriguez-Arnao, T. Tiong, J. Miell, A.M. Mcgregor, R.J.M. Ross, Differential response of hepatic mRNA levels for the growth hormone receptor (GHR) and growth hormone binding protein (GHBP) in rats with altered thyroid status. 13th Joint Meeting of British Endocrinology Societies, March, 1994. ( Bournemouth , UK )