skip to content »

Pathology

Houston, Texas

Department of Pathology
Pathology
not shown on screen

Faculty

H. Daniel Lacorazza, Ph.D. Assistant Professor of Pathology and Immunology

photoAlt

Education

  • Licentiate in Biochemistry (Bachelor's and Master's degree in Science), School of Biochemistry, University of Buenos Aires, Argentina

  • Ph.D. (graduated with honors), School of Biochemistry, University of Buenos Aires, Argentina

Post-doctoral Training

  • Visiting Fellow, National Institutes of Health (NEI/LI), Bethesda. Gene therapy using ex-vivo retroviral gene transfer and transplantation

  • Research Fellow, Immunology Program, Memorial Sloan Kettering Cancer Center, New York. Development and function of T cells

  • Senior Research Scientist, Laboratory of Molecular Aspects of Hematopoiesis, Memorial Sloan Kettering Cancer Center, New York. Role of the transcription factor MEF/ELF4 in immunity and hematopoiesis

Area of Interest

  • Experimental Hematopoiesis: maintenance of hematopoietic stem cells

  • Developmental Immunology: T cell development and function

Current Position

  • Assistant Professor of Pathology and Immunology

Other Positions

  • Faculty, Immunology Program

  • Faculty, Translational Biology and Molecular Medicine (TBMM) Program

Honors and Awards

  • The Howard Temin Award, National Cancer Institute, National Institutes of Health

  • The Moran Foundation Award, Baylor College of Medicine

  • Junior Faculty Seed Fund Award, Baylor College of Medicine

  • Lauri Strauss Leukemia Foundation award

  • The Dan L. Duncan Cancer Center, NCI Development Fund Pilot Project

Membership on professional organizations

  • Associate Member, The Dan L. Duncan Cancer Center

  • Associate Member, Stem Cell and Regenerative Medicine (STaR) Center

  • Associate Member, Texas Gulf Coast Digestive Disease Center (DDC)

  • Member of the American Society of Hematology (ASH) since 2003

  • Member of the National Eye Institute Laboratory of Immunology Clinical Branch (LICB) Alumni Association

Representative Publications

  1. Lacorazza, H.D., Yamada, T., Liu, Y., Miyata, Y., Sivina, M., Nunes, J., and Nimer, S. The transcription factor MEF (ELF4) regulates the quiescence of primitive hematopoietic cells. Cancer Cell (2006) 9, 175-187. Featured Article on the Cover
  2. Lacorazza, H.D., Miyazaki, Y., Di Cristofano, A., Deblasio, T., Hedvat, C., Cordon-Cardo, C., Mao, S., Zhang, J., Pandolfi, P.P., and Nimer, S.D. The ETS Protein MEF Plays a Critical Role in Perforin Gene Expression and the Development of Natural Killer Cells and NK-T Cells. Immunity. 2002, 17: 437-449. Featured Article on the Cover
  3. Aifantis I, Borowski C, Gounari F, Lacorazza HD, Nikolich-Zugich J, von Boehmer H. A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development. Nature Immunology. 2002 May; 3(5): 483-8
  4. Lacorazza, H.D., Porritt, H., and Nikolic-Zugic, J. Dysregulated expression of preTα? reveals the opposite effects of pre-TCR at successive stages of T cell development. Journal of Immunology 2001, 167:5689-5696
  5. Lacorazza, H.D., Tucek, C., Vasovic, L., Remus, K., Nikolic-Zugic, J. Premature TCRαβ expression and signaling in pre-thymocytes impair thymocyte expansion and partially block their development. Journal of Immunology 2001, 166:3184-3193
  6. Lacorazza, H.D., Flax, J., Snyder, E., and Jendoubi, M. Expression of human β-hexosaminidase α-subunit gene in mouse brains upon engraftment of transduced progenitor cells. Nature Medicine 1996; 2 (4), 424-429