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Pathology

Houston, Texas

Department of Pathology
Pathology
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Faculty

Dean P. Edwards, Ph.D.Professor

Dean P. Edwards

Education

  • Graduate: Medical College of Georgia, School of Graduate Studies Department of Endocrinology, Augusta, GA, Ph.D. Endocrinology, 1971-1976

  • Undergraduate: Ohio University, B.S. Zoology, 1965-1969 Athens, Ohio

Training

Post-doctoral Training

  • Postdoctoral Fellowship, Dr. William McGuire (mentor), Department of Medicine/Oncology, University of Texas Health Science Center, San Antonio, Texas, 1977-1980

Specialty

  • Endocrinology

Area of Interest

  • Research: Steroid hormone receptors, molecular mechanism of action and their role in breast cancer and other endocrine disorders.

Current Position

  • Professor

Professional Positions Held

  • Professor, Departments of Molecular and Cellular Biology and Pathology, Baylor College of Medicine, Houston, Texas, 2005-present

  • Professor (tenure), Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado, 1996-2005

  • Associate Professor (tenure), Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado, 1990-1996

  • Assistant Professor, Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado, 1985-1990

  • Research Assistant Professor, Department of Medicine/Oncology, University of Texas Health Science Center, San Antonio, Texas, 1982-1984

  • Instructor of Medicine, Department of Medicine/Oncology, University of Texas Health Science Center, San Antonio, Texas, 1980-1982

Other Positions

  • Director, Interdepartmental Molecular Biology Program,University of Colorado Health Sciences Center, Denver, Colorado, 2000-2005

  • Dan L. Duncan Cancer Center at Baylor College of Medicine, Director: Recombinant Protein Expression/Proteomics Core, 2005-Present

  • Dan L. Duncan Cancer Center at Baylor College of Medicine, Associate Director Research Infrastructure, 2006-Present

Honors and Awards

  • Distinguished Alumnus Award, Medical College of Georgia, School of Graduate Studies, May 1996

  • Dean's Mentorship Award, University of Colorado Health Sciences Center, May 2000

Membership on professional organizations

  • Journal editorial boards:

  • Breast Cancer Research and Treatment, 1986-Present

  • Molecular Endocrinology, 1993-1997, 1999-2003

  • J. Steroid Biochemistry and Molecular Biology, 1994-Present

  • Steroids, 1999-Present

  • Endocrinology, 2007-Present

  • Professional Societies

  • Membership

  • Endocrine Society

  • American Association for Cancer Research

  • American Association for the Advancement of Science

  • Elected Positions

  • Annual Meeting Steering Committee, Endocrine Society, 2003-2006

  • Associates Council - Endocrine Society, 1998-2000

Representative Publications

  1. Buser, A.D., Gass Handel, E.K., Wyszomierski, S.L., Doppler, W., Leonhardt, S.A., Schaack, J., Rosen, J.M., Watkin, H., Anderson, S.M., and Edwards, D.P. Progesterone receptor repression of prolactin/Stat5-mediated transcription of the β-casein gene in mammary epithelial cells. Mol. Endocrinol., (In press, 2006).
  2. Roemer, S.C., Sherman, L., Donham, D., Edwards, D.P., and Churchill, M.E.A. Crystal structure of the progesterone receptor DNA binding domain reveals DNA interactions with the minor groove flanking the core progesterone response element. (In press, 2006.)
  3. Wardell, S.E., Sherman, L., Kwok, S.C., Hodges, R.S., and Edwards, D.P. Regulation of the amino terminal transcription activation domain of progesterone receptor by a co-factor-induced protein folding mechanism. Mol. Cell. Biol., 25:8792-8808, 2005
  4. Edwards, D.P. Regulation of signal transduction pathways by estrogen and progesterone. In: Annual Review of Physiology 67:335-376, 2005
  5. Wardell, S.E., and Edwards, D.P. Mechanisms controlling agonist and antagonist potential of selective progesterone receptor modulators. Seminars in Reproductive Medicine 23:9-21, 2005.
  6. Narayanan, R., Edwards, D.P., and Weigel, N.L. Human progesterone receptor displays cell cycle dependent changes in transcription activity. Mol. Cell. Biol. 25:2885-2898, 2005.
  7. Narayanan, R., Adigun, A.A., Edwards, D.P., and Weigel, N.L. Cyclin dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/cdk2 as a progesterone receptor for coactivator. Mol. Cell. Biol. 25:264-277, 2005.
  8. Melvin, V.S., Harrell, C., Adelman, J.S., Kraus, W.L., Churchill, M.E.A., and Edwards, D.P. The role of the carboxyl terminal extension (CTE) of the estrogen receptor α and β DNA binding domain in DNA binding and interaction with HMGB. J. Biol. Chem. 279:14763-14771, 2004.
  9. Wardell, S.E., Boonyaratanakornkit, V., Adelman, J.S., Aronheim, A., and Edwards, D.P. Jun dimerization protein-2 functions as a progesterone receptor N-terminal coactivator. Mol. Cell Biol. 22:5451-5466, 2002.
  10. Melvin, V.S., Roemer, S., Churchill, M., and Edwards, D.P. The carboxyl terminal extension (CTE) of the DNA binding domain of steroid receptors determines interaction with and functional response to HMGB. J. Biol. Chem. 277:25115-15124, 2002.
  11. Press, M., Spaulding, B., Groshen, S., Kaminsky, D., Hagerty, M., Sherman, L., Christensen, K., and Edwards, D.P. Comparison of different antibodies for detection of progesterone receptor in breast cancer. Steroids 67:799-813, 2002.
  12. Schultz, J.R., Loven, M.A., Melvin, V., Edwards, D.P. and Nardulli, A.M. Differential modulation of DNA conformation by estrogen receptors α and β. J. Biol. Chem. 277:8702-8707, 2002.
  13. Boonyaratanakornkit, V., Porter, M., Ribon, V., Sherman, L., Anderson, S.A., Miller, W.T., Edwards, D.P. Progesterone receptor contains a proline rich sequence in the amino terminus that directly interacts with SH3 domains and activates Src family tyrosine kinases. Mol. Cell 8:269-280, 2001.
  14. Doppler, W., Windegger, M., Tomassi, J., Lechner, J., Rusconi, S., Cato, A.C.B., Almlöf, Lidén, J., Okret, S., Gustafsson, J-Ĺ., Richard-Foy, H., Starr, D.B., Klocker, H., Edwards, D., Soratroi, C. Expression level dependent contribution of glucocorticoid receptor domains for functional interaction with STAT5. Mol. Cell Biol. 21:3266-3279, 2001.
  15. Knotts, T.A., Orkiszewski, R.S., Cook, R.G., Edwards, D.P., Weigel, N.L. Identification of a phosphorylation site in the hinge region of the human progesterone receptor and additional amino-terminal phosphorylation sites. J. Biol. Chem. 276:8475-8483, 2001.