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Pathology

Houston, Texas

Department of Pathology
Pathology
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Faculty

Thomas A. Cooper, M.D.Professor

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Education

  • B.S. Moravian College, Bethlehem, PA, cum laude with honors, 1973-1977

  • M.D. Temple University Medical School, Philadelphia, PA, 1978-1982

Post-doctoral Training

  • University of California, San Francisco, CA

Specialty

  • Molecular biology

Area of Interest

  • Alternative splicing in development and disease

Current Position

  • Professor, Department of Pathology, Baylor College of Medicine, Houston, TX

  • Professor, Department of Molecular and Cellular Biology (joint appointment), Baylor College of Medicine, Houston, TX

Honors and Awards

  • 1981 NIH Medical Research Trainee predoctoral award

  • NRSA Postdoctoral Fellowship (NIH), 1982-1985

  • Bank of America Giannini Foundation Postdoctoral Award, 1985-1986

  • March of Dimes Basil O'Connor Starter Scholar Research Award, 1991-1994

  • Established Investigator Award, American Heart Association, 1992-1997

  • Blaffer Lecturer, M.D. Anderson Cancer Center, Houston, TX, 1998

  • Michael E. DeBakey, M.D. Excellence in Research Award, 1999

  • Named to the S. Donald Greenberg Chair of Pathology, 2003

Representative Publications

  1. Please note that this is a SELECTED list

  2. Cooper, T.A. (2006) A reversal of fortune for myotonic dystrophy? N. Engl. J. Med. 355, 1825-1827.

  3. Ranum L.P. and Cooper, T.A. (2006) RNA-mediated neuromuscular disorders. Ann. Rev. Neuroscience, 29, 259-277.

  4. Orengo, J., Bundman, D., and Cooper, T.A. A bichromatic fluorescent reporter for cell-based screens of alternative splicing Nucl. Acids Res. (In Press).

  5. Cooper, T.A. (2005) Alternative splicing regulation impacts heart development. Cell 120, 1-2.

  6. Ladd, A.N., Taffet, G.E., Hartley, C., Kearney, D.L. and Cooper, T.A. (2005) Cardiac-specific repression of CELF activity disrupts alternative splicing and causes cardiomyopathy. Mol. Cell. Biol. 25, 6267-6278.

  7. Ho, T., Savkur, R.S., Poulos, M., Mancini., M.M., Swanson, M.S., and Cooper, T.A. (2005) Co-localization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy. J. Cell Science 118 2923-2933.

  8. Ladd, A.L. Stenberg, M.G., Swanson, M.S., and Cooper, T.A. (2005) A dynamic balance between activation and repression regulates pre-mRNA alternative splicing during heart development. Dev. Dyn. 233, 783-793.

  9. Han, J. and Cooper, T.A. (2005) Characterization of CELF splicing activation and repression domains in vivo. Nucl. Acids Res. 33, 2769-2780.

  10. Ho, T., Bundman, D., Armstrong, D.L., and Cooper, T.A. (2005) Transgenic mice expressing CUG-BP1 reproduce the myotonic dystrophy pattern of splicing. Hum. Mol. Genet. 14, 1539-1547.

  11. Faustino, N.A. and Cooper, T.A. (2005) Identification of putative new splicing targets for ETR-3 using its SELEX sequences. Mol. Cell. Biol. 25, 879-887.

  12. Ho, T., Charlet-B., N., Poulos, M., Singh, G., Swanson, M.S., and Cooper, T.A. (2004) Muscleblind proteins regulate alternative splicing. EMBO J. 23, 3103-3112.

  13. Ladd, A.N. and Cooper, T.A. (2004) Nuclear-cytoplasmic localization of the RNA binding protein ETR-3 is controlled by multiple localization elements. J. Cell Science 117, 3519-3529.

  14. Savkur, R.S., Philips, A.V., Cooper, T.A., Dalton, J.C., Moseley, M.L., Ranum, L.P.W., Day, J.W. (2004) Insulin receptor splicing alteration in myotonic dystrophy type 2. Am. J. Hum. Genet. 74:1309­1313.

  15. Ladd, A.N., Nguyen, N.H. Malhotra, K and Cooper, T.A. (2004) CELF6, a member of the CELF family of RNA binding proteins, regulates MSE-dependent alternative splicing. J. Biol. Chem. 279,17756-17764.

  16. Faustino, N.A. and Cooper, T.A. (2003) RNA splicing and human disease. Genes Dev. 17, 419-437.