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Pathology

Houston, Texas

Department of Pathology
Pathology
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Faculty

Gustavo Ayala, M.D.Professor
R. Clarence and Irene H. Fulbright Chair in Pathology
Director

Gustavo Ayala

Education

  1. M.D.

Residency

  1. Chief Resident, Anatomic Pathology: Yale-New Haven Hospital, Yale University, New Haven, CT., July 1994-July 1995

  2. Anatomic Pathology Resident: Georgetown University Hospital, Department of Pathology, Washington D.C., March 1992-July 1994

  3. Anatomic Pathology Resident: National Cancer Institute, Aregua, Paraguay; under Antonio Cubilla M.D., former attending pathologist at Memorial- Sloan Kettering Cancer Center, New York, NY, 1/ 1990-12/ 1990 & 9/1991-2/1992

Specialty

  1. Pathology

Board Certification

  1. Anatomic Pathology

Area of Interest

  1. Prostate Cancer

Current Position

  1. Professor

Professional Positions Held

  1. Professor with Tenure, Department of Pathology and Urology, Baylor College of Medicine, September 2005

  2. R. Clarence and Irene H. Chair in Pathology, July 2005

  3. Associate Professor with Tenure, Department of Pathology and Urology, Baylor College of Medicine, July 2002- Present

  4. Assistant Professor, Tenure Tract, Department of Pathology, Baylor College of Medicine, December 1998- July 2002

  5. Assistant Professor, Pathology at MCP-Hahnemann School of Medicine, Allegheny University, July 1995-December 1998

  6. Staff Pathologist: Allegheny University Hospitals, Hahnemann. Surgical Pathology and Cytopathology and Autopsy Pathology, July 1995-December 1998

  7. Staff Pathologist: Allegheny University Hospitals, MCP. Surgical Pathology and Cytopathology and Autopsy Pathology, July 1995-December 1998

  8. Staff Pathologist: Allegheny University Hospitals, City Line. Surgical Pathology and Cytopathology and Autopsy Pathology, July 1995-December 1998

  9. Staff Pathologist: Allegheny University Hospitals, Parkview. Surgical Pathology and Cytopathology and Autopsy Pathology, July 1995-December 1998

Honors and Awards

  1. R. Clarence and Irene H. Chair in Pathology, July 2005

  2. O'Neal-Spjut Award, Department of Pathology, Baylor College of Medicine, 2005

Membership on professional organizations

  1. American Society of Clinical Pathologists

  2. College of American Pathologists

  3. United States and Canadian Academy of Pathology

  4. Houston Society of Clinical Pathologists (Scientific Program Chair, 2001-02)

  5. Texas Society of Pathologists

  6. Harris County Medical Society

  7. Texas Medical Association

  8. International Society of Urologic Pathology

  9. American Urologic Association

  10. Arthur Purdy Stout Society of Surgical Pathology

  11. American Association for Cancer Research

  12. Association for Molecular Pathologists

Representative Publications

  1. Elsa F Velazquez, Gustavo Ayala , Hao Liu, Alcides Chaux, Magali Zanotti, Jose Torres, Soung I Cho, Jose E Barreto, Fernando Soares, Antonio L Cubilla. Histologic grade and perineural invasion are more important than tumor thickness as predictor of nodal metastasis in squamous cell carcinoma of penis invading 5-10 mm. Am J Surg Pathol. 2008 Jul;32(7):974-9. PMID: 18460979 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18460979

  2. Bortezomib-mediated inhibition of steroid receptor coactivator-3 degradation leads to activated Akt. Ayala G, Yan J, Li R, Ding Y, Thompson TC, Mims MP, Hayes TG, MacDonnell V, Lynch RG, Frolov A, Miles BJ, Wheeler TM, Harper JW, Tsai MJ, Ittmann MM, Kadmon D. Clin Cancer Res. 2008 Nov 15;14(22):7511-8.PMID: 19010869 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19010869

  3. Cancer-related axonogenesis and neurogenesis in prostate cancer. Ayala GE, Dai H, Powell M, Li R, Ding Y, Wheeler TM, Shine D, Kadmon D, Thompson T, Miles BJ, Ittmann MM, Rowley D. Clin Cancer Res. 2008 Dec 1;14(23):7593-603. PMID: 19047084 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19047084

  4. Yanagisawa N, Li R, Wheeler TM, Ayala G. Reactive Stroma in Needle Biopsies Predicts Biochemical Recurrence-Free Survival in Patients After Radical Prostatectomy. Accepted to Human Pathology. Hum Pathol. 2007 Sep 12; PMID: 17868773 http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17868773&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

  5. Acevedo VD, Gangula RD, Freeman KW, Li R, Zhang Y, Wang F, Ayala GE, Peterson LE, Ittmann M, Spencer DM. Inducible FGFR-1 Activation Leads to Irreversible Prostate Adenocarcinoma and an Epithelial-to-Mesenchymal Transition. Cancer Cell. 2007 Dec;12(6):559-71. PMID: 18068632 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18068632

  6. Tahir SA, Frolov A, Hayes TG, Mims MP, Miles BJ, Lerner SP, Wheeler TM, Ayala G , Thompson TC, Kadmon D. Preoperative serum caveolin-1 as a prognostic marker for recurrence in a radical prostatectomy cohort. Clin Cancer Res 2006;12(16):4872-4875. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16914574

  7. Ayala G , Sala T, Timme T, Dai H, Ittman MM, Li R, Frolov A, Wheeler TM, Rowley D, Thompson TC. Stromal Antiapoptotic Paracrine Loop in Perineural Invasion of Prostatic Carcinoma. Accepted to Cancer Research. Cancer Res. 2006 May 15;66(10):5159-64. PMID: 16707439. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16707439&query_hl=1&itool=pubmed_docsum

  8. Ayala G, Satoh T, Li R, Shalev M, Gdor Y, Aguilar-Cordova E, Frolov A, Wheeler TM, Miles BJ, Rauen K, Teh BS, Butler EB, Thompson TC, Kadmon D. Biological response determinants in HSV-tk + ganciclovir gene therapy for prostate cancer. Mol Ther 2006;13(4):716-728.PMID: 16480930. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16480930

  9. Dai H, Wheeler TM, Li R, Diaz de Vivar A, Frolov A, Chen X, Ayala G . Increased Pim-2 Is Associated with Aggressive Disease and Promotes Perineural Invasion by Decreasing Apoptosis in Prostate Cancer. Prostate. 2005 Nov 1;65(3):276-86. PMID: 16015593 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16015593&query_hl=1&itool=pubmed_docsum

  10. Gustavo E. Ayala , Hong Dai, Rile Li, Michael Ittmann, Timothy C. Thompson , and David Rowley, Thomas M. Wheeler. Bystin in Perineural Invasion of Prostate Cancer. Prostate. 2005 Oct 21; PMID: 16245277 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16245277&query_hl=1&itool=pubmed_docsum

  11. Haqq C, Li R, Khodabakhsh D, Frolov A, Derynck M, Yamamoto K, Yu M, Ginzinger D, Downs T, Shinohara K, Thompson T, Wheeler TM, Carroll P, and Ayala G . Ethnic and Racial Differences in Prostate Stromal Estrogen Receptor alpha. Prostate 2005. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15880569

  12. Powell MS, Li R, Dai H, Sayeeduddin M, Wheeler TM, Ayala G : Neuroanatomy of the normal prostate, Prostate 2005. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15806576

  13. Ayala GE , Dai H, Ittmann M, et al. Growth and survival mechanisms associated with perineural invasion in prostate cancer. Cancer Res 2004;64(17):6082-90. PMID: 15342391 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15342391

  14. Ayala G , Thompson T, Yang G, Frolov A, Li R, Scardino P, Ohori M, Wheeler T, Harper W: High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence, Clin Cancer Res 2004, 10:6572-6578. PMID: 15475446 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15475446

  15. Krishnan B, Lechago J, Ayala G , Truong L: Intraoperative consultation for renal lesions. Implications and diagnostic pitfalls in 324 cases, Am J Clin Pathol 2003, 120:528-535. PMID: 14560563 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14560563

  16. Ayala G , Tuxhorn JA, Wheeler TM, Frolov A, Scardino PT, Ohori M, Wheeler M, Spitler J, Rowley DR: Reactive stroma as a predictor of biochemical-free recurrence in prostate cancer, Clin Cancer Res 2003, 9:4792-4801. PMID: 14581350 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14581350

  17. Ayala G , Wang D, Wulf G, Frolov A, Li R, Sowadski J, Wheeler TM, Lu KP, Bao L: The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer, Cancer Res 2003, 63:6244-6251. PMID: 14559810 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14559810

  18. Yang G, Ayala G, De Marzo A, Tian W, Frolov A, Wheeler TM, Thompson TC, Harper JW: Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival, Clin Cancer Res 2002, 8:3419-3426. PMID: 12429629 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12429629

  19. Ayala G , Wheeler T, Shine HD, Schmelz M, Frolov A, Chakraborty S, Rowley D: In vitro dorsal root ganglia and human prostate cell line interaction: redefining perineural invasion in prostate cancer, Prostate 2001, 49:213-223. PMID: 11746267 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11746267

  20. Ayala G , Wheeler TM, Shalev M, Thompson TC, Miles B, Aguilar-Cordova E, Chakraborty S, Kadmon D: Cytopathic effect of in situ gene therapy in prostate cancer, Hum Pathol 2000, 31:866-870. PMID: 10923926 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10923926

  21. List of representative publications

  22. Dai H, Li R, Wheeler T, Ozen M, Ittmann M, Anderson M, Wang Y, Rowley D, Younes M, Ayala GE. Enhanced survival in perineural invasion of pancreatic cancer: an in vitro approach. Hum Pathol. 2006 Nov 9; PMID: 17097719
    Epub ahead of print

  23. Ayala GE, Dai H, Tahir SA, Li R, Timme T, Ittmann M, Frolov A, Wheeler TM, Rowley D, Thompson TC. Stromal antiapoptotic paracrine loop in perineural invasion of prostatic carcinoma. Cancer Res. 2006 May 15;66(10):5159-64. PMID: 16707439
    PubMed - indexed for MEDLINE

  24. Ayala G, Satoh T, Li R, Shalev M, Gdor Y, Aguilar-Cordova E, Frolov A, Wheeler TM, Miles BJ, Rauen K, Teh BS, Butler EB, Thompson TC, Kadmon D. Biological response determinants in HSV-tk + ganciclovir gene therapy for prostate cancer. Mol Ther. 2006 Apr;13(4):716-28. Epub 2006 Feb 15. PMID: 16480930
    PubMed - indexed for MEDLINE

  25. Ayala GE, Dai H, Li R, Ittmann M, Thompson TC, Rowley D, Wheeler TM. Bystin in perineural invasion of prostate cancer. Prostate. 2006 Feb 15;66(3):266-72. PMID: 16245277
    PubMed - indexed for MEDLINE

  26. Dai H, Li R, Wheeler T, Diaz de Vivar A, Frolov A, Tahir S, Agoulnik I, Thompson T, Rowley D, Ayala G. Pim-2 upregulation: biological implications associated with disease progression and perinueral invasion in prostate cancer. Prostate. 2005 Nov 1;65(3):276-86. PMID: 16015593
    PubMed - indexed for MEDLINE

  27. Powell MS, Li R, Dai H, Sayeeduddin M, Wheeler TM, Ayala GE. Neuroanatomy of the normal prostate. Prostate. 2005 Sep 15;65(1):52-7. PMID: 15806576
    PubMed - indexed for MEDLINE

  28. Zhou HJ, Yan J, Luo W, Ayala G, Lin SH, Erdem H, Ittmann M, Tsai SY, Tsai MJ. SRC-3 is required for prostate cancer cell proliferation and survival. Cancer Res. 2005 Sep 1;65(17):7976-83. PMID: 16140970
    PubMed - indexed for MEDLINE

  29. Ayala G, Thompson T, Yang G, Frolov A, Li R, Scardino P, Ohori M, Wheeler T, Harper W. High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence. Clin Cancer Res. 2004 Oct 1;10(19):6572-8. Erratum in: Clin Cancer Res. 2005 Jul 15;11(14):5330. PMID: 15475446
    PubMed - indexed for MEDLINE

  30. Ayala GE, Dai H, Ittmann M, Li R, Powell M, Frolov A, Wheeler TM, Thompson TC, Rowley D. Growth and survival mechanisms associated with perineural invasion in prostate cancer. Cancer Res. 2004 Sep 1;64(17):6082-90. PMID: 15342391
    PubMed - indexed for MEDLINE

  31. Ayala G, Tuxhorn JA, Wheeler TM, Frolov A, Scardino PT, Ohori M, Wheeler M, Spitler J, Rowley DR. Reactive stroma as a predictor of biochemical-free recurrence in prostate cancer. Clin Cancer Res. 2003 Oct 15;9(13):4792-801. PMID: 14581350
    PubMed - indexed for MEDLINE

  32. Ayala G, Wang D, Wulf G, Frolov A, Li R, Sowadski J, Wheeler TM, Lu KP, Bao L. The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer. Cancer Res. 2003 Oct 1;63(19):6244-51. PMID: 14559810
    PubMed - indexed for MEDLINE

  33. Tuxhorn JA, Ayala GE, Smith MJ, Smith VC, Dang TD, Rowley DR. Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling. Clin Cancer Res. 2002 Sep;8(9):2912-23. PMID: 12231536
    PubMed - indexed for MEDLINE

  34. Ayala GE, Wheeler TM, Shine HD, Schmelz M, Frolov A, Chakraborty S, Rowley D. In vitro dorsal root ganglia and human prostate cell line interaction: redefining perineural invasion in prostate cancer. Prostate. 2001 Nov 1;49(3):213-23. PMID: 11746267
    PubMed - indexed for MEDLINE

  35. Ayala G, Wheeler TM, Shalev M, Thompson TC, Miles B, Aguilar-Cordova E, Chakraborty S, Kadmon D: Cytopathic effect of in situ gene therapy in prostate cancer, Hum Pathol 2000, 31:866-870.
    PubMed - indexed for MEDLINE

  36. Cubilla AL, Reuter VE, Gregoire L, Ayala G, Ocampos S, Lancaster WD, Fair W: Basaloid squamous cell carcinoma: a distinctive human papilloma virus-related penile neoplasm: a report of 20 cases, Am J Surg Pathol 1998, 22:755-761.
    PubMed - indexed for MEDLINE