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Pathology

Houston, Texas

Department of Pathology
Pathology
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Faculty

Gustavo Ayala, M.D.Professor
R. Clarence and Irene H. Fulbright Chair in Pathology
Director

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Education

  • M.D.

Residency

  • Chief Resident, Anatomic Pathology: Yale-New Haven Hospital, Yale University, New Haven, CT., July 1994-July 1995

  • Anatomic Pathology Resident: Georgetown University Hospital, Department of Pathology, Washington D.C., March 1992-July 1994

  • Anatomic Pathology Resident: National Cancer Institute, Aregua, Paraguay; under Antonio Cubilla M.D., former attending pathologist at Memorial- Sloan Kettering Cancer Center, New York, NY, 1/ 1990-12/ 1990 & 9/1991-2/1992

Specialty

  • Pathology

Board Certification

  • Anatomic Pathology

Area of Interest

  • Prostate Cancer

Current Position

  • Professor

Professional Positions Held

  • Professor with Tenure, Department of Pathology and Urology, Baylor College of Medicine, September 2005

  • R. Clarence and Irene H. Chair in Pathology, July 2005

  • Associate Professor with Tenure, Department of Pathology and Urology, Baylor College of Medicine, July 2002- Present

  • Assistant Professor, Tenure Tract, Department of Pathology, Baylor College of Medicine, December 1998- July 2002

  • Assistant Professor, Pathology at MCP-Hahnemann School of Medicine, Allegheny University, July 1995-December 1998

  • Staff Pathologist: Allegheny University Hospitals, Hahnemann. Surgical Pathology and Cytopathology and Autopsy Pathology, July 1995-December 1998

  • Staff Pathologist: Allegheny University Hospitals, MCP. Surgical Pathology and Cytopathology and Autopsy Pathology, July 1995-December 1998

  • Staff Pathologist: Allegheny University Hospitals, City Line. Surgical Pathology and Cytopathology and Autopsy Pathology, July 1995-December 1998

  • Staff Pathologist: Allegheny University Hospitals, Parkview. Surgical Pathology and Cytopathology and Autopsy Pathology, July 1995-December 1998

Honors and Awards

  • R. Clarence and Irene H. Chair in Pathology, July 2005

  • O'Neal-Spjut Award, Department of Pathology, Baylor College of Medicine, 2005

Membership on professional organizations

  • American Society of Clinical Pathologists

  • College of American Pathologists

  • United States and Canadian Academy of Pathology

  • Houston Society of Clinical Pathologists (Scientific Program Chair, 2001-02)

  • Texas Society of Pathologists

  • Harris County Medical Society

  • Texas Medical Association

  • International Society of Urologic Pathology

  • American Urologic Association

  • Arthur Purdy Stout Society of Surgical Pathology

  • American Association for Cancer Research

  • Association for Molecular Pathologists

Representative Publications

  1. Dai H, Li R, Wheeler T, Ozen M, Ittmann M, Anderson M, Wang Y, Rowley D, Younes M, Ayala GE. Enhanced survival in perineural invasion of pancreatic cancer: an in vitro approach. Hum Pathol. 2006 Nov 9; PMID: 17097719
    Epub ahead of print

  2. Ayala GE, Dai H, Tahir SA, Li R, Timme T, Ittmann M, Frolov A, Wheeler TM, Rowley D, Thompson TC. Stromal antiapoptotic paracrine loop in perineural invasion of prostatic carcinoma. Cancer Res. 2006 May 15;66(10):5159-64. PMID: 16707439
    PubMed - indexed for MEDLINE

  3. Ayala G, Satoh T, Li R, Shalev M, Gdor Y, Aguilar-Cordova E, Frolov A, Wheeler TM, Miles BJ, Rauen K, Teh BS, Butler EB, Thompson TC, Kadmon D. Biological response determinants in HSV-tk + ganciclovir gene therapy for prostate cancer. Mol Ther. 2006 Apr;13(4):716-28. Epub 2006 Feb 15. PMID: 16480930
    PubMed - indexed for MEDLINE

  4. Ayala GE, Dai H, Li R, Ittmann M, Thompson TC, Rowley D, Wheeler TM. Bystin in perineural invasion of prostate cancer. Prostate. 2006 Feb 15;66(3):266-72. PMID: 16245277
    PubMed - indexed for MEDLINE

  5. Dai H, Li R, Wheeler T, Diaz de Vivar A, Frolov A, Tahir S, Agoulnik I, Thompson T, Rowley D, Ayala G. Pim-2 upregulation: biological implications associated with disease progression and perinueral invasion in prostate cancer. Prostate. 2005 Nov 1;65(3):276-86. PMID: 16015593
    PubMed - indexed for MEDLINE

  6. Powell MS, Li R, Dai H, Sayeeduddin M, Wheeler TM, Ayala GE. Neuroanatomy of the normal prostate. Prostate. 2005 Sep 15;65(1):52-7. PMID: 15806576
    PubMed - indexed for MEDLINE

  7. Zhou HJ, Yan J, Luo W, Ayala G, Lin SH, Erdem H, Ittmann M, Tsai SY, Tsai MJ. SRC-3 is required for prostate cancer cell proliferation and survival. Cancer Res. 2005 Sep 1;65(17):7976-83. PMID: 16140970
    PubMed - indexed for MEDLINE

  8. Ayala G, Thompson T, Yang G, Frolov A, Li R, Scardino P, Ohori M, Wheeler T, Harper W. High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence. Clin Cancer Res. 2004 Oct 1;10(19):6572-8. Erratum in: Clin Cancer Res. 2005 Jul 15;11(14):5330. PMID: 15475446
    PubMed - indexed for MEDLINE

  9. Ayala GE, Dai H, Ittmann M, Li R, Powell M, Frolov A, Wheeler TM, Thompson TC, Rowley D. Growth and survival mechanisms associated with perineural invasion in prostate cancer. Cancer Res. 2004 Sep 1;64(17):6082-90. PMID: 15342391
    PubMed - indexed for MEDLINE

  10. Ayala G, Tuxhorn JA, Wheeler TM, Frolov A, Scardino PT, Ohori M, Wheeler M, Spitler J, Rowley DR. Reactive stroma as a predictor of biochemical-free recurrence in prostate cancer. Clin Cancer Res. 2003 Oct 15;9(13):4792-801. PMID: 14581350
    PubMed - indexed for MEDLINE

  11. Ayala G, Wang D, Wulf G, Frolov A, Li R, Sowadski J, Wheeler TM, Lu KP, Bao L. The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer. Cancer Res. 2003 Oct 1;63(19):6244-51. PMID: 14559810
    PubMed - indexed for MEDLINE

  12. Tuxhorn JA, Ayala GE, Smith MJ, Smith VC, Dang TD, Rowley DR. Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling. Clin Cancer Res. 2002 Sep;8(9):2912-23. PMID: 12231536
    PubMed - indexed for MEDLINE

  13. Ayala GE, Wheeler TM, Shine HD, Schmelz M, Frolov A, Chakraborty S, Rowley D. In vitro dorsal root ganglia and human prostate cell line interaction: redefining perineural invasion in prostate cancer. Prostate. 2001 Nov 1;49(3):213-23. PMID: 11746267
    PubMed - indexed for MEDLINE

  14. Ayala G, Wheeler TM, Shalev M, Thompson TC, Miles B, Aguilar-Cordova E, Chakraborty S, Kadmon D: Cytopathic effect of in situ gene therapy in prostate cancer, Hum Pathol 2000, 31:866-870.
    PubMed - indexed for MEDLINE

  15. Cubilla AL, Reuter VE, Gregoire L, Ayala G, Ocampos S, Lancaster WD, Fair W: Basaloid squamous cell carcinoma: a distinctive human papilloma virus-related penile neoplasm: a report of 20 cases, Am J Surg Pathol 1998, 22:755-761.
    PubMed - indexed for MEDLINE