skip to content »

Pathology

Houston, Texas

Department of Pathology
Pathology
not shown on screen

Faculty

Adekunle M. Adesina, M.D., Ph.D. Professor of Pathology

Adekunle M. Adesina

Education

  1. M.B., B.S. (MD equivalent) 1980 - University of Ibadan, Ibadan, Nigeria

  2. M.Sc. 1985 - University of Ibadan, Ibadan, Nigeria

  3. Ph.D. 1997 - McGill University, Montreal, Quebec, Canada

Internship

  1. Rotational Internship - University College Hospital, Ibadan, Nigeria, 1980 - 1981

Residency

  1. Anatomic Pathology - University College Hospital, Ibadan, Nigeria, 1982 - 1986

Fellowship

  1. Anatomic Pathology and Neuropathology - Medical Center Hospital and The University of Vermont, Burlington, VT, 1986 - 1990

  2. Surgical Pathology, Cytopathology and Molecular Pathology, Fox Chase Cancer Center, Philadelphia, PA, 1992 - 1994

Post-doctoral Training

  1. Molecular Genetics - Ludwig Institute for Cancer Research and Montreal Neurological Institute, Montreal, Quebec, Canada, 1990 - 1992

Specialty

  1. Anatomic Pathology

  2. Neuropathology

  3. Molecular Pathology

Board Certification

  1. Anatomic Pathology and Neuropathology, 1990

  2. Molecular Genetic Pathology, 2001

Area of Interest

  1. Molecular Neuro-oncology

  2. Neuromuscular disease - histologic diagnosis and applications of molecular methods in diagnosis

Current Position

  1. Associate Professor of Pathology

  2. Chief of Neuropathology Program

  3. Director of Neuropathology Fellowship Training Program

  4. Director of Molecular Neuropathology Laboratory

Professional Positions Held

  1. Associate Professor of Pathology and Director of Neuropathology, Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2001 - 2002

  2. Assistant Professor of Pathology Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 1994 - 2001

Honors and Awards

  1. Honorable mention Neil Award for the best paper in Experimental Neuropathology by the American Association of Neuropathologists at the International Congress of Neuropathology, San Francisco, September 10 - 16, 2006

  2. Unsung Hero award - Given by the Department of Pathology in appreciation of dedication and support of the Department of Pathology teaching programs, 2001

  3. Richard W Leech Teaching Award - presented by the Department of Pathology house staff to the faculty member who has best exemplified excellence in teaching, 2001

  4. Medical Research Council of Canada Postdoctoral Research Fellowship Award, 1992

  5. Departmental prize for best student in Hematology, 1979

  6. George Edington prize for best student in Pathology, 1979

  7. Distinction in Pathology, College of Medicine, University of Ibadan, 1977

  8. Full Medical Education Federal Government Scholarship award, 1975

Membership on professional organizations

  1. Member, United States and Canadian Academy of Pathology, 2004

  2. Inspector, Anatomic Pathology and Molecular Pathology, College of American Pathologists, 1997 - present

  3. Member, Association for Molecular Pathology, 1995 - present

  4. Member, American Association for the Advancement of Science, 1995 - present

  5. Member, Oklahoma State Association for Pathologists, 1994 - 2002

  6. Member, American Association of Neuropathologists, 1991 - present

  7. Member, College of American Pathologists, 1991 - present

Representative Publications

  1. Adesina AM, Lopez-Terrada D, Wong KK, Gunaratne P, Nguyen Y, Pulliam J, Margolin J and Finegold MJ: Gene expression profiling reveals signatures characterizing histological subtypes of hepatoblastoma and global deregulation in cell growth and survival pathways. Hum Pathol 2009; 40(6):843-853

  2. López-Terrada D, Gunaratne P, Adesina AM , Pulliam J, Hoang DM, Nguyen Y, Mistreta T-A, Margolin J,  Finegold MJ: Histologic subtypes of hepatoblastoma are characterized by differential canonical Wnt and Notch pathway activation in arrested DLK+ precursors. Hum Pathol 2009;40(6):783-794

  3. Takei H, Nguyen, Y, Mehta V Chintagumpala M, Dauser RC, Adesina AM : Low Level Copy Gain versus Amplification of myc Oncogenes in Medulloblastoma: Utility in Predicting Prognosis and Survival. J Neurosurg Pediatr . 2009 Jan;3(1):61-5

  4. Shu Q, Wong KK, Su J, Adesina A , Yu L-T, Tsai-Lee Y, Antalffy B, Perlaky L, Dauser R, Chintagumpala M, Blaney SM, Lau CC, Li X-N: Direct orthotopic transplantation of fresh surgical specimen preserves cancer stem cell pool in clinically relevant mouse models of medulloblastoma and glioma. Stem Cells 2008 Jun; 26 ( 6 ): 1414-24 ; Apr 10; [Epub ahead of print]

  5. Castellino RC, De Bortoli M, Lin LL, Skapura DG, Rajan JA, Adesina AM , Perlaky L, Irwin MS, Kim JYH: Overexpressed TP73 Induces Apoptosis in Medulloblastoma. BMC Cancer 2007 7:127

  6. Takei H, Yogeswaren S, Wong K-K, Lau C, Chintagumpala M, Dauser R, Adesina AM : E xpression of oligodendroglial differentiation markers in pilocytic astrocytomas identifies two clinical subsets and shows a significant correlation with proliferation index and progression free survival. J Neuro-Oncol, 2008 Jan; 86 ( 2 ): 183-90 . Epub 2007 Aug 10

  7. Adesina AM , Nguyen Y, Mehta V, Takei H, Stangeby P, Crabtree S, Chintagumpala M, Gumerlock MK: FoxG1 dysregulation is a frequent event in medulloblastoma. J Neuro-Oncol 2007 Nov; 85 ( 2 ): 111-22 . Epub 2007 May 24

  8. Adesina , AM , Nguyen, Y, Guanaratne, P, Pulliam, J, Lopez-Terrada, L, Margolin, J, Finegold, M: FoxG1 is overexpressed in hepatoblastoma. Hum Pathol 2007 Mar;38(3):400-9. Epub 2007 Jan 10

  9. Wong, KK, Tsang, YTM, Chang, Y-M, Su, J, Di Francesco, AM, Meco, D, Riccardi, R, Perlaky, L, Dauser, RC, Adesina, A, Bhattacharjee, M, Chintagumpala, M, Lau, C: Genome-wide Allelic Imbalance Analysis of Pediatric Gliomas by Single Nucleotide Polymorphic Allele (SNP) Array Cancer Res, 2006; 66 (23): 11172

  10. Maryam Fouladi, Susan M. Blaney, Tina Young Poussaint, Burgess B. Freeman III, Roger McLendon, Christine Fuller, Adekunle M. Adesina, Michael L. Hancock, Joanna S. Remack, Mary K. Danks, Clinton Stewart, Percy Ivy, James M. Boyett, Larry E. Kun, Amar Gajjar: A Phase II Study of Oxaliplatin in Children with Recurrent or Refractory Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumors and Atypical Teratoid Rhabdoid Tumors: A Pediatric Brain Tumor Consortium Study. Cancer. 2006 Oct 3; [Epub ahead of print]

  11. Qin Shu, Bobbie Antalffy, Adekunle Adesina, Jack Su, Ching-Nan Ou, Torsten Pietsch, Susan Blaney, Ching C. Lau, Xiao-Nan Li.: Valproic Acid Prolongs Survival Times of SCID Mice Bearing Intracerebellar Orthotopic Medulloblastoma Xenografts. Clin Cancer Res 2006 Aug 1;12(15):4687-94.

  12. Massimiliano De Bortoli, Robert C. Castellino, Xin-Yan Lu, Jeffrey Deyo, Lisa Marie Sturla, Adekunle M Adesina, Laszlo Perlaky, Scott L. Pomeroy, Ching C. Lau, Tsz-Kwong Man, Pulivarthi H. Rao, John Y.H. Kim: Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8. BMC Cancer 2006, 6:223

  13. Xiao-Nan Li, Qin Shu, Jack M. Su, Adekunle M. Adesina, Kwong Kwok Wong, Laszlo Perlaky, Barbara A. Antalffy, Susan Blaney, Ching C. Lau: Differential Expression of Survivin Splice Isoforms in Medulloblastomas. Neuropath Applied Neurobiol 2007, 33, 67–76

  14. Margaret C Thompson, Christine Fuller, Twala L Hogg, James Dalton, David Finkelstein, Ching C Lau, Murali Chingtagumpala, Adekunle Adesina, David M Ashley, Stewart J Kellie, Michael D Taylor, Tom Curran, Amar Gajjar, and Richard J Gilbertson: Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol. 2006 Apr 20;24(12):1924-31. Epub 2006 Mar 27

  15. Adesina AM: Intraoperative consultation in the diagnosis of pediatric brain tumors. Arch Pathol Lab Med 2005,129 (12):1653 -1660

  16. Wong K-K, Chang Y-M, Tsang YTM, Perlacky L, Su J, Adesina A, Armstrong DL, Bhattacharjee M, Dauser R, Blaney S, Chintagumpala M, Lau CC: Expression analysis of juvenile pilocytic astrocytoma by oligonucleotide microarray reveals two potential subgroups. Cancer Res, 2005, 65:76-84

  17. Adesina AM, Dunn ST, Nalbantoglu J: Expression of p27kip1 and p53 gene in medulloblastoma; relationship with cell proliferation and survival. Path Res & Pract 2000; 196:243-250.

  18. Adesina AM, Dooley N, Nalbantoglu J, Yong VW: Differential role of protein kinase C mediated signaling in the proliferation of medulloblastoma cell lines. Int J Oncol 1998; 12:759-768.

  19. Adesina AM, Nalbantoglu J, Cavenee WK: p53 gene mutation and mdm2 gene amplification are uncommon in medulloblastoma. Cancer Res 1994; 54:5649-5651

  20. Verma A, Bradley WG, Adesina AM, Sofferman R, Pendlebury WW: Inclusion body myositis with cricopharyngeus muscle involvement and severe dysphagia. Muscle & Nerve 1991; 14:470-473.

  21. Tandan R, Taylor R, Adesina A, Sharma K, Fries T, Pendlebury : Benign autosomal syndrome of neuronal Charcot-Marie tooth disease, ptosis, parkinsonism and dementia. Neurology 1990; 40:773-779.