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Pathology

Houston, Texas

Blood cells, including the immune system, are formed from bone marrow progenitors following a specific pattern of gene expression
Pathology
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Selected Publications

The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells. Lacorazza, H.D., Yamada, T., Liu, Y., Miyata, Y., Sivina, M., Nunes, J., Nimer, S.D. Cancer Cell (2006), 9:3. Featured article on the cover.

Garcia-Barros, M., Lacorazza, H.D., Petrie, H., Haimovitz-Friedman, A., Cardon-Cardo, C., Nimer, S., Fuks, Z., Kolesnick, R. Host acid sphingomyelinase regulates microvascular function not tumor immunity. Cancer Res. (2004) 64(22): 8285-8291.

Lacorazza, H.D. and Nikolic-Zugic, J. Exclusion and Inclusion of TCR? Proteins during T-cell Development in TCR-transgenic and normal mice. J. Immunol. (2004) 173(9): 5591-5600.

Lacorazza, H.D., and Nimer, S. The emerging role of the transcription factor MEF in hematopoiesis (review). Blood Cells, Molecules and Diseases. (2003) 31, 342-350.

Lacorazza, H.D., Miyazaki, Y., Di Cristofano, A., Deblasio, T., Hedvat, C., Cordon-Cardo, C., Mao, S., Zhang, J., Pandolfi, P.P., and Nimer, S.D. The ETS Protein MEF Plays a Critical Role in Perforin Gene Expression and the Development of Natural Killer Cells and NK-T Cells. Immunity. 2002, 17: 437-449. Featured article on the cover..

Aifantis I, Borowski C, Gounari F, Lacorazza HD, Nikolich-Zugich J, von Boehmer H. A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development. Nat Immunol. 2002 May; 3(5): 483-8.

Lacorazza, H.D., Porritt, H., and Nikolic-Zugic, J. Dysregulated expression of preT?? reveals the opposite effects of pre-TCR at successive stages of T cell development. J. Immunol. 2001, 167:5689-5696.

Lacorazza, H.D., Tucek, C., Vasovic, L., Remus, K., Nikolic-Zugic, J. Premature TCR?? expression and signaling in pre-thymocytes impair thymocyte expansion and partially block their development. J. Immunol. 2001, 166:3184-3193.

Lacorazza, H.D., Guevara, J.A., Weksler, M.E., and Nikolic-Zugic, J. Failure of rearranged TCR transgenes to correct age-associated thymic involution. J. Immunol. 1999, 163 (8): 4262-4268.

Lacorazza, H.D., Flax, J., Snyder, E., and Jendoubi, M. Expression of human β-hexosaminidase α-subunit gene in mouse brains upon engraftment of transduced progenitor cells. Nature Medicine 1996; 2 (4), 424-429.