Laboratory of
Developmental Immunology and Hematopoiesis
H. Daniel Lacorazza, Ph.D.
Assistant Professor
Departments of Pathology and Immunology
Faculty, Translational Biology and Molecular Medicine Program
Research Member, The Dan L. Duncan Cancer Center
Associate Member, Stem Cell and Regenerative Medicine (STaR) Center
Associate Member, Texas Gulf Coast Digestive Disease Center (DDC)
Baylor College of Medicine
Research Interest
My group studies the molecular events that control hematopoiesis and development of the immune system. Mature blood cells have an important role in regulating the hematopoietic process by cell-cell interactions in the bone marrow stroma and by production of soluble factors (e.g. chemokines, cytokines, growth factors). These processes ensure a competent and functional environment capable of responding to stress such as infections, cytotoxic injuries (i.e. chemotherapy), and even preventing the establishment of malignant cells. Knowing how these events are regulated is key to develop therapies to improve the immune and hematological reconstitution post immune suppression or myeloid ablation.
