Publications
Orengo, J.P., Chambon, P., Metzger, D., Mosier, D.R., Snipes, G.J. and Cooper, T.A. (2008) Expanded CTG repeats within the DMPK 3¹ UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy. Proc. Nat¹l Acad. Sci. 105, 2646-2651. PubMed
Kuyumcu-Martinez, N.M., Wang, G.S., and Cooper, T.A. (2007) Increased steady state levels of CUG-BP1 in Myotonic Dystrophy 1 are due to PKC-mediated hyper-phosphorylation. Mol. Cell 28, 68-78. PubMed
Wang, G.S., Kearney, D.L., De Biasi, M., Taffet, G.E., and Cooper, T.A. (2007) Elevated CUGBP1 is an early event in an inducible heart-specific mouse model of myotonic dystrophy. J. Clin. Invest. 117, 2802-2811. PubMed
Orengo, J.P. and Cooper, T.A. (2007) Alternative splicing in disease in Alternative splicing in the post-genomic era, B.R. Graveley and B. Blencowe, ed. Landes publishing; pp. 212-223.
Chapple , J.P., Anthony, K., Martin, T.R., Cooper, J.D. , Cooper, T.A ., and Gallo, J-M. (2007) Expression, localization and Tau Exon 10 splicing activity of the brain RNA-binding protein TNRC4. Hum. Mol. Gen. 16, 2760-2769 . PubMed
Dhaenens , C.M. , Schraen-Maschke , S. , Vingtdeux , V. , Vanbrussel , E. , Leroy , O. , Delplanque , J., Tran , H., Delacourte , A. , Vermersch , P. , Gruffat , H. , Sergeant , A , Mahadevan , M. , Ishiura , S. , Buée , L: , Cooper, T.A. , Caillet-Boudin , M.L. , Charlet-Berguerand , N. , Sablonnière , B. , and Sergeant , N. Altered splicing of Tau and MBNL1 by long expanded CUG repeats in Myotonic Dystrophy of Type I brain: new insights in DM1 pathophysiology. Experimental Neurology (In Press)
Wang, G.S. and Cooper T.A. (2007) Splicing in disease: disruption of the splicing code and the decoding machinery. Nature Rev. Genet. 8, 749-761.PubMed
Cooper, T.A. (2007) Regulation of chloride ion conductance during skeletal muscle development and in disease. Amer. J. Physiol: Cell Physiology 292, C1245-1247.PubMed
Bland, C.S. and Cooper, T.A. (2007) Micromanaging alternative splicing during muscle differentiation Dev Cell 12, 171-17.PubMed
Cooper, T.A. (2006) A reversal of fortune for myotonic dystrophy? N Engl J Med. 355, 1825-1827. PubMed
Ranum L.P. and Cooper, T.A. (2006) RNA-mediated neuromuscular disorders. Ann. Rev. Neuroscience, 29, 259-277. PubMed
Orengo, J., Bundman, D., and Cooper, T.A. (2006) A bichromatic fluorescent reporter for cell-based screens of alternative splicing Nucl. Acids Res. 34, e148. PubMed
Singh, G, N. and Cooper, T.A. (2006) A minigene reporter for identification and analysis of cis elements and trans factors affecting pre-mRNA splicing.(2006) BioTechniques 41,177-181. PubMed
de Haro, M., Al-Ramahi, I,, De Gouyon, B., Ukani, L., Rosa, A., Faustino, N.A., Ashizawa, T., Cooper, T.A. and Botas, J. (2006) MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of Myotonic Dystrophy Type 1. Hum. Mol. Gen. 15, 2138-2145. PubMed
Thornton, C.A., Swanson, M.S., and Cooper, T.A. (2006) The RNA-mediated disease process in myotonic dystrophy. In Genetic Instabilities and Hereditary Neurological Diseases (Second Edition). T. Ashizawa and R.D. Wells (Eds.). p. 37-54.
Kuyumcu-Martinez, N.M. and Cooper, T.A. (2006) Mis-regulation of alternative splicing causes pathogenesis in myotonic dystrophy. Progress in Molecular and Subcellular Biology 44, 133-159. PubMed
Cooper, T.A. (2005) Use of minigene systems to dissect alternative splicing elements. Methods 37, 331-340 PubMed
Ladd, A.N., Taffet, G.E., Hartley, C., Kearney, D.L. and Cooper, T.A. (2005) Cardiac-specific repression of CELF activity disrupts alternative splicing and causes cardiomyopathy. Mol. Cell. Biol. 25, 6267-6278 PubMed
Leroy, O., Wang, J., Maurage, C.A., Parent, M., Cooper, T., Buee, L., Sergeant, N., Andreadis, A., Caillet-Boudin, M.L. (2006) Brain-specific change in alternative splicing of Tau exon 6 in myotonic dystrophy type 1. Biochim Biophys Acta. 1762, 460-467.
Han, J. and Cooper, T.A. (2005) Characterization of CELF splicing activation and repression domains in vivo Nucl. Acids Res. 33, 2769-2780 PubMed
Ho, T., Bundman, D., Armstrong, D.L., and Cooper, T.A. (2005) Transgenic mice expressing CUG-BP1 reproduce the myotonic dystrophy pattern of splicing. Hum. Mol. Genet. 14, 1539-1547. PubMed
Ladd, A.L. Stenberg, M.G., Swanson, M.S., and Cooper, T.A. (2005) A dynamic balance between activation and repression regulates pre-mRNA alternative splicing during heart development. Dev. Dyn. 233, 783-793. PubMed
Ho, T., Savkur, R.S., Poulos, M., Mancini., M.M., Swanson, M.S., and Cooper, T.A. (2005) Co-localization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy J. Cell Science 118, 2923-2933. PubMed
Cooper, T.A. (2005) Alternative splicing regulation impacts heart development. Cell 120, 1-2. PubMed
Cooper, T. A. (2005) In vivo SELEX strategies, p. 840-852. In R. K. Hartmann, A. Bindereif, A. Schon, and E. Westhof (ed.), Handbook of RNA Biochemistry, vol. 2. Wiley-VCH Verlag GmbH and Co, Weinheim.
Faustino, N.A. and Cooper, T.A. (2005) Identification of putative new splicing targets for ETR-3 using its SELEX sequences. Mol. Cell. Biol. 25, 879-887.PubMed
Ladd, A.N. and Cooper, T.A. (2004) Nuclear-cytoplasmic localization of the RNA binding protein ETR-3 is controlled by multiple localization elements. J. Cell Science 117, 3519-3529. PubMed
Ho, T., Charlet-B., N., Poulos, M., Singh, G., Swanson, M.S., and Cooper, T.A. (2004) Muscleblind proteins regulate alternative splicing. EMBO J. 23, 3103-3112.PubMed
Singh, G., Charlet-B., N., Han, J., and Cooper, T.A. (2004) ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo. Nucl. Acids Res. 32, 1232-1241.PubMed
Ladd, A.N., Nguyen, N.H. Malhotra, K and Cooper, T.A. (2004) CELF6, a member of the CELF family of RNA binding proteins, regulates MSE-dependent alternative splicing. J. Biol. Chem. 279,17756-17764.PubMed
Savkur, R.S., Philips, A.V., Cooper, T.A., Dalton, J.C., Moseley, M.L., Ranum, L.P.W., Day, J.W. (2004) Insulin receptor splicing alteration in myotonic dystrophy type 2. Am. J. Hum. Genet. 74:1309-1313.PubMed
Faustino, N.A. and Cooper, T.A. (2003) RNA splicing and human disease. Genes Dev. 17, 419-437. PubMed
Gromak, N., Matlin, A.J., Cooper, T.A., and Smith, C.W.J. (2003) Antagonistic regulation of alpha-actinin alternative splicing by CELF proteins and polypyrimidine tract binding protein. RNA 9, 443-456.PubMed
Ladd, A.N., Cooper, T.A. (2002) Finding signals that regulate alternative splicing in the post-genomic era. Genome Biology 3, 8.1-8.16. PubMed
Timchenko LT, Tapscott SJ, Cooper TA, Monckton DG. (2002) Myotonic dystrophy: discussion of molecular basis. Adv Exp Med Biol. 516, 27-45.PubMed
Charlet-B., Singh, G, N., Philips, A.V., Grice, E.A., and Cooper, T.A (2002). Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing. Mol. Cell 10, 45-53. PubMed
Charlet-B., Singh, G, N., Logan, P.E., and Cooper, T.A. (2002) Dynamic antagonism between CELF proteins and PTB regulate splicing of a muscle-specific exon in both muscle and nonmuscle cells. Mol. Cell 9, 649-658.PubMed
Cooper, T.A. (2001) Highlights of alternative splicing regulation session: yes, no, maybe--a history of paradigm shifts. Science STKE. Oct 23;2001(105):PE35.PubMed
Savkur, R., Philips, A.V., and Cooper, T.A. (2001) Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy. Nat Gen. 29, 40-47.PubMed
Stickeler, E., Fraser, S.D., Honig, A., Chen, A.L., Berget, S.M. and Cooper, T.A. (2001) The RNA binding protein YB-1 recognizes A/C-rich exon enhancers and stimulates splicing of the CD44 alternative exon v4. EMBO J. 20, 3821-3830.PubMed
Ladd, A.N., Charlet-B., N., and Cooper, T.A. (2001) The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing Mol. Cell. Biol. 21,1285-1296.PubMed
Ryan, K.J., Charlet-B., N., and Cooper, T.A. (2000) Binding of purH to a muscle-specific splicing enhancer correlates with exon inclusion in vivo. J. Biol. Chem. 275, 20618-20626.PubMed
Philips, A.V. and Cooper, T.A. (2000) RNA and human disease. Cell. Mol. Life Sci. 57, 235-249.PubMed
Stark, J.M., Cooper, T.A., Roth M.B. (1999) The relative strengths of SR protein-mediated associations of alternative and constitutive exons can influence alternative splicing. J. Biol. Chem., 274, 29838-29842.PubMed
Cooper, T.A. (1999) Strategies for defining pre-mRNA cis elements that regulate cell specific splicing in "RNA-Protein Interactions", Susan R. Haynes, Ed.; Methods in Molecular Biology Series, John M. Walker, Ed., (Humana Press), vol. 118, 391-403.PubMed
Cooper, T.A. (1999) In vivo SELEX in vertebrate cells in "RNA-Protein Interactions", Susan R. Haynes, Ed.; Methods in Molecular Biology Series, John M. Walker, Ed., (Humana Press), vol 118, 405-417.PubMed
Stoss, O., Cooper, T.A., and Stamm, S. (1999) Alternative splicing determines the intracellular localization of the muscle specific nucleolar proteins NOP30-1 and NOP30-2. J. Biol.Chem. 274, 10951-10962.PubMed
Cooper, T.A. (1998) Muscle-specific splicing of a heterologous exon mediated by a single muscle-specific splicing enhancer from the cardiac troponin T gene. Mol. Cell. Biol. 18, 4519-4525.PubMed
Philips, A.V., Timchenko, L.T., and Cooper, T.A. (1998) Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy. Science 280, 737-741.PubMed
Elrick, L.L., Humphrey, M.B., Cooper, T.A., and Berget, S.M. (1998) A short sequence within two purine-rich enhancers determines 5' splice site specificity. Mol. Cell. Biol. 18, 343-352.PubMed
Cooper, T.A. and Mattox, W. (1997) The regulation of splice site selection and its role in human disease. Amer. J. Hum. Gen. 61, 259-266.
Coulter, L., Landree, M., and Cooper, T.A. (1997) Identification of a new class of exonic splicing enhancers by in vivo selection. Mol. Cell. Biol. 17, 2143-2150.PubMed
Ryan, K.J. and Cooper, T.A. (1996) Muscle-specific splicing enhancers regulate inclusion of the cardiac troponin T alternative exon in embryonic skeletal muscle. Mol. Cell. Biol. 16, 4014-4023.PubMed
Ramchatesingh, J., Zahler, A.M., Neugebauer, K.M., Roth, M.B. and Cooper, T.A. (1995) A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer. Mol. Cell. Biol. 15, 4898-4907.PubMed
Humphrey, M.B., Bryan, J., Cooper, T.A., Berget, S.M. (1995) A 32 nucleotide exon splicing enhancer regulates usage of competing 5' splice sites in a differential internal exon. Mol. Cell. Biol. 15, 3979-3988.PubMed
Lee, A.B. and Cooper, T.A. (1995) An improved direct PCR screen of bacterial colonies: wooden toothpicks inhibit PCR amplification. BioTechniques 18, 225-226.
Xu, R., Teng, J., and Cooper, T.A. (1993). The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element. Mol. Cell. Biol. 13, 3660-3674. PubMed
Cooper, T.A. (1992). In vitro splicing of cardiac troponin T precursors: exon mutations disrupt splicing of the upstream intron. J. Biol. Chem. 267, 5330-5338.PubMed