Young-Hwa Goo, Ph.D.
Postdoctoral Fellow
Funding: American Heart Association, Texas Affiliate
yg145076@bcm.edu
713-798-5021
Joined the lab: July 2004
Research Interests
DM pathogenesis results from disrupted RNA processing secondary to disrupted function of RNA-binding proteins by the expanded RNA repeats. CUG-BP1 and ETR-3 are well-characterized alternative splicing regulators. Increased activity of CUG-BP1 is responsible for the aberrant regulation of cTNT, IR, and ClC-1 alternative splicing observed in DM1. My subject is to find proteins that interact with CUG-BP and ETR-3. These interactors will be isolated in vivo and in vitro using a combination of approaches including GST-pull downs and Tandem Affinity Purification (TAP) assays and will ultimately be identified using mass spectrometry. I expect these results will help us find new proteins involved in DM pathogenesis and will provide an understanding of the mechanism of alternative splicing regulation by CUG-BP and ETR-3.
Publications
Goo YH , Na SY, Zhang H, Xu J, Hong S, Cheong J, Lee SK, Lee JW Interaction between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation. J Biol Chem, 2004, Feb 20, 279(8):713-5
Goo YH* , Sohn YC*, Kim DH*, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa KO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW Activating signal cointegrator-2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. Mol Cell Biol, 2003, Jan;23(1):140-9.
Jung DJ, Sung HS, Goo YH , Lee HM, Park OK, Jung SY, Lim J, Kim HJ, Lee SK, Kim TS, Lee JW, Lee YC. Novel transcription coactivator complex containing activating signal cointegrator 1. Mol Cell Biol, 2002, Jul:22(14):5203-11.
Kim SW, Cheong C, Sohn YC, Goo YH , Oh WJ, Park JH, Joe SY, Kang HS, Kim DK, Kee C, Lee JW, Lee HW. Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with catarct. Mol Cell Biol, 2002, Dec;22(24):8409-14.
Jang MK*, Goo YH* , Sohn YC, Kim YS, Lee SK, Kang H, Cheong J, Lee JW Ca2+/calmodulin-dependent protein kinase IV stimulates nuclear factor-kappa B transactivation via phosphorylation of the p65 subunit. J Biol Chem, 2001, Jun 8:276(23):20005-10
Goo YH , Park MS, Jhun BH Chronic Treatment of Ethanol Inhibits Proliferation of Normal Fibroblasts, But Not oncogenic ras-transformed Cells The Journal of Applied Pharmacology 1999 6(4) 345-350