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The recent realization that most human genes generate multiple protein isoforms via alternative splicing has revealed an extensive degree of regulation that remains to be explored. We are interested in understanding the mechanisms of this regulation, from how RNA binding proteins regulate splicing of individual pre-mRNAs to the signaling events that coordinate splicing networks during development. We also study myotonic dystrophy, the most common form of adult onset muscular dystrophy, in which disrupted splicing regulation causes the primary features of the disease.
Tom Cooper, M.D.
S. Donald Greenberg Professor of Pathology
Dr. Cooper's contact information
Lab Phone: (713) 798-5021
Fax: (713) 798-5838
Department of Pathology
Live cell imaging of CUG RNA foci bound to
GFP-MBNL1 (time-lapse video) T. Ho.