CELF Proteins
There are six CELF (pronounced, “self”) protein genes in vertebrates. The nomenclature of CELF proteins is rather confusing. Table 1 includes the most commonly used names. CELF proteins contain three RNA binding domains (RNA recognition motifs or RRMs) and a domain of 160-230 residues called the linker or divergent domain that is unique in the database and differs between CELF paralogues. The divergent domain contains regions required for splicing activation and repression that are separate from regions required for RNA binding ( Singh et al. 2004, Han et al. 2005 .) These regions are thought to interact with proteins within activation or repression complexes.
|
|
|
|
|
% identity |
|
|
|
|
|
|
to CUGBP1 |
Chrom. |
BRUNOL2 |
CUGBP1 |
CELF1 |
CUG-BP |
|
--- |
11p11 |
BRUNOL3 |
CUGBP2 |
CELF2 |
ETR-3 |
NAPOR |
78% |
10p13 |
BRUNOL1 |
|
CELF3 |
|
TNRC4, CAGH4 |
44% |
1q21 |
BRUNOL4 |
|
CELF4 |
|
|
42% |
18q12 |
BRUNOL5 |
|
CELF5 |
|
|
39% |
19p13 |
BRUNOL6 |
|
CELF6 |
|
|
46% |
15q24 |
Table 1: CELF protein nomenclature