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Pathology

Houston, Texas

Cooper Lab
Pathology
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CELF Proteins

There are six CELF (pronounced, “self”) protein genes in vertebrates. The nomenclature of CELF proteins is rather confusing. Table 1 includes the most commonly used names. CELF proteins contain three RNA binding domains (RNA recognition motifs or RRMs) and a domain of 160-230 residues called the linker or divergent domain that is unique in the database and differs between CELF paralogues. The divergent domain contains regions required for splicing activation and repression that are separate from regions required for RNA binding ( Singh et al. 2004, Han et al. 2005 .) These regions are thought to interact with proteins within activation or repression complexes.

 

 

 

 

 

% identity

 

 

 

 

 

 

to CUGBP1

Chrom.

BRUNOL2

CUGBP1

CELF1

CUG-BP

 

---

11p11

BRUNOL3

CUGBP2

CELF2

ETR-3

NAPOR

78%

10p13

BRUNOL1

 

CELF3

 

TNRC4, CAGH4

44%

1q21

BRUNOL4

 

CELF4

 

 

42%

18q12

BRUNOL5

 

CELF5

 

 

39%

19p13

BRUNOL6

 

CELF6

 

 

46%

15q24

Table 1: CELF protein nomenclature