Faculty: Newton J. Coker, M.D. (713-798-5112), Helen Cohen, Ed.D.(713-798-5931).
Research Focus: Mechanisms of vestibular compensation and visual-vestibular interaction. Vestibular patients are studied before and after surgery with an extensive battery of neurotologic tests. Rehabilitative strategies in the dizzy patient using physical and occupational therapy techniques and rehabilitative strategies for low vision patients.
Recent BCM trainees:
Brandon Isaacson, M.D. (clinical fellow)
Carrie Roller, M.D. (resident): Practice variability and the development of sensorimotor countermeasures
Greg Ator, M.D. (clinical fellow): Postural reflexes in vestibular patients.
Carol Bauer, M.D. (clinical fellow): Histopathology of the temporal bone.
Glenn Knox, M.D. (clinical fellow): Human vestibular physiological measures.
Randy Zane, M.D. (resident): Posturography in normal and vestibular patients.
Cochlear Biophysics Lab
Faculty: W. Brownell, Ph.D. (713-798-8540)
Research focus: Electro-motility, structure, electrochemical gradients, lipid composition and transmembrane potential of guinea pig outer hair cell (OHC).
Recent BCM trainees:
Larry Simon, M.D. (resident)
Walter Kutz, M.D. (resident): Membrane fluidity in the lateral wall of the OHC covaries in response to osmotic challenges
Eric Weitzel, M.D. (resident): Pressure induced changes in OHC pH and OHC piezoelectricity
Romaine Johnson, M.D. (resident)
Matthew Kirby, M.D. (resident): Effect of CPZ and salicylate on membrane mechanics
Thanh Nguyen, M.D. (resident): Cholesterol content of OHC lateral wall
Omid Abassi, M.D. (resident): Contribution of phosphate buffer to intracellular pH of OHC.
John Oghalai, M.D. (resident): The effect of the subsurface cisterna on OHC transmembrane potential.
Amy Chen, M.D. (resident): Spatial variation of OHC plasma membrane potential.
Allen Lue, M.D. (med student/resident): Effect of salicylate on OHC lateral wall stiffness.
Mas Takashima, M.D. (resident): Temperature dependence of pipette aspiration
Mike Yium (med student): Electroanatomical analysis of OHC capacitance.
Alpen Patel (med student): Visualization of OHC lateral wall components.
Head and Neck Immunology
Faculty: Holly H. Birdsall, M.D., Ph.D. (713-794-7775)
Research focus: Regulation leukocyte movement across endothelial barriers in the context of ischemic injury, HIV infection, and other types of inflammation.
Recent BCM trainees:
Susan Eicher, M.D. (resident): Mechanisms of leukocyte-mediated injury in Herpes zoster-infected neural cells.
Andrew de Jong, M.D. (resident): Regulation of monocyte transendothelial migration in HIV infection.
Laboratory of Cochlear Mechanics and Hearing Loss
Faculty: John S. Oghalai, M.D. (713-798-3234)
Research focus: This laboratory is dedicated towards understanding mechanisms within the cochlea that underlie progressive sensorineural hearing loss and towards developing techniques to improve human hearing. Our research objectives are to better understand the relationship between the passive and active mechanical properties within the the cochlea and to develop techniques that can be used to modulate the function of the cochlear amplifier. The ultimate goals of these efforts are to develop therapeutic interventions for noise-induced and age-related hearing loss (sensorineural hearing loss).
Recent trainees:
Etai Funk, M.D.
Ann Marie Visosky, M.D.
Amman Mazhar
Brad Evans, M.D (resident): Modulation of basilar membrance stiffness.
Rob Schmidt
Drew Sawyer
Nicola Schug
Audrey Nath
Gentiana Wenzel, M.D.
Molecular Genetics Laboratory
Faculty: Raye Lynn Alford, Ph.D., FACMG
Research Focus: Molecular genetic basis of human hearing loss including gene discovery, mutation detection, genotype-phenotype correlations, and diagnostic technology development.
Pediatric Otolaryngology - Clinical research
Faculty: Ellen Friedman, M.D. (832-822-3268), Marcelle Sulek, M.D. (832-822-3267), and Carla Giannoni, M.D. (821-822-3267)
Research focus: Pediatric otolaryngology.
M.D. Anderson Cancer Center — Extradepartmental site
Faculty & Research focus: :
Gary Clayman, M.D.: Oncogenes in head and neck cancer.
Reuben Lotan, Ph.D.: Retinoids in cellular differentiation.
Recent BCM trainees:
Thanh-Van Nguyenh. M.D. (resident)
Chris Prichard, M.D. (resident)
Gabe Calzada, M.D. (resident)
Matthew Kirby, M.D. (resident)
Andrea McMurphy, M.D. (resident)
James Ludwick, M.D. (resident)
Janet Lee, M.D. (resident)
Jason Greenberg, M.D. (resident): Selection for anoikis-resistance of squamous cell carcinoma of the oral tongue
Carla Giannoni, M.D. (resident): HER-2 expression and loss of heterozygosity in salivary tumors.
Mark Overholt, M.D. (resident): Oncogenes in head and neck cancer.
Mike Sicard, M.D. (resident): Adenovirus transfer into squamous cell carcinoma lines.
Troy Callender, M.D. (resident): Amplification and overexpression of PRad proto-oncogene in primary squamous cell carcinomas of the head and neck.
For additional information contact: W. Brownell, Ph.D. (713-798-8540)
By email: brownell@bcm.edu
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©2001-2006 Baylor College of Medicine
Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery
Mail: One Baylor Plaza, NA102, Houston, TX 77030
Phone: 713-798-5906
E-mail: oto@bcm.tmc.edu
Last modified: July 12, 2006
