John S. Oghalai, M.D.

Assistant Professor

Clinic Chief and Director of The Hearing Center at Texas Children's Hospital

Adjunct Assistant Professor, Department of Bioengineering, Rice University

Board Certification
American Board of Otolaryngology

Undergraduate Degree
University of Wisconsin - Madison, Wisconsin

Medical School
University of Wisconsin - Madison, Wisconsin

Residency
Otolaryngology, Baylor College of Medicine, Houston, Texas

Fellowship
Otology, Neurotology, and Skull Base Surgery, University of California - San Francisco, San Francisco, California

Curriculum Vitae

Laboratory of Cochlear Mechanics and Hearing Loss

Clinical and Research Interests
Otology (chronic otitis media, cholesteatoma, otosclerosis, and conductive hearing loss), Neurotology (cochlear implantation, inner ear disease, and facial nerve disorders), and Skull Base Surgery (acoustic neuroma, meningiomas, glomus jugulare tumors, temporal bone and other skull base tumors).

Patient Information Links:
Acoustic Neuroma and Skull Base Surgery

Cochlear Implants

Hearing and Hair Cells

Tympanic Membrane, Middle Ear and Mastoid Disease

Clinic Appointments
713-798-3200

Adult Clinic Location
Baylor Otolaryngology
Neurosensory Center
6501 Fannin Street, Suite NA102
Houston, Texas 77030

Pediatric Clinic Appointments
832-822-3250

Pediatric Clinic Location
The Hearing Center at Texas Children's Hospital
Clinical Care Center
6701 Fannin Street, 5th Floor
Houston, Texas 77030

Academic Phone Number
713-798-3234

E-mail Address
jso@bcm.edu

Selected Publications:

Isaacson B, Coker NJ, Vrabec JT, Yoshor D, Oghalai JS. Invasive cerebrospinal fluid cysts and cephaloceles of the petrous apex. Otol Neurotol 2006;27:1131-41.

Visosky AMB, Isaacson B, Oghalai JS. Circumferential petrosectomy for petrous apicitis and cranial base osteomyelitis. Otol Neurotol 2006;27:1003-13.

Tang H-y, Fang P, Ward PA, Schmitt E, Manolidis S, Oghalai JS, Roa BB, Alford RL. DNA sequence analysis of GJB2 encoding connexin 26: observations from a population of hearing impaired cases and variable carrier rates, complex genotypes and ethnic stratification of alleles among controls. Am J Med Genet A 2006;140:2401-15.

Paylor R, Glaser B, Mupo A, Ataliotis P, Spencer C, Sobotka A, Sparks C, Choi CH, Oghalai J, Curran S, Murphy KC, Monks S, Williams N, O'Donovan MC, Owen MJ, Scambler PJ, Lindsay E. Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. Proc Natl Acad Sce USA 2006;103:7729-34.

Prichard CN, Isaacson B, Oghalai JS, Coker NJ, Vrabec JT. Adult spontaneous CSF otorrhea: correlation with radiographic empty sella. Otolaryngol Head Neck Surg 2006;134:767-71.

Patel N, Oghalai JS. Familial unilateral cochlear nerve aplasia. Otol Neurotol 2006;27:443-4.

Nakagawa T, Oghalai JS, Saggau P, Rabbit RD, Brownell WE. Photometric recording of transmembrane potential in outer hair cells. J Neural Eng 2006;3:79-86.

Oghalai JS. Revision cochlear implantation after device failure. Oper Tech Otolaryngol Head Neck Surg 2005;16:146-8.

Evans MB, Tonini R, Shope CD, Oghalai JS, Jerger JF, Insull W, Brownell WE. Dyslipidemia and auditory function. Otol Neurotol 2006;27:609-14.

Tang H-Y, Zia A, Oghalai JS, Pereira FA, Alford RL. High frequency of the IVS2-2A>G DNA sequence variation in SLC26A5, encoding the cochlear motor protein prestin, precludes its involvement in hereditary hearing loss. BMC Med Genet 2005;6:30.

Calzada G, Isaacson B, Yoshor D, Oghalai JS. Surgical approaches to the hypoglossal canal. Skull Base Surg (in press).

McMurphy AB, Oghalai JS. Repair of iatrogenic temporal lobe encephalocele following canal wall down mastoidectomy in the presence of active cholesteatoma. Otol Neurotol 2005;26:587-94.

Oghalai JS, Buxbaum JL, Jackler RK, McDermott MV. Skull base chondrosarcoma originating from the petroclival junction. Otol Neurotol 2005;26:1052-60.

Choi C-H, Oghalai JS. Predicting the effect of post-implant cochlear fibrosis on residual hearing. Hear Res 2005;205:193-200.

Pletcher SD, Oghalai JS, Reeck JB, Cheung SW. Management of superior cancal dehiscence syndrome with extensive skull base deficiency. ORL Otorhinolaryngol Relat Spec 2005;67:192-5.

Oghalai JS. The cochlear amplifier: augmentation of the traveling wave within the iner ear. Curr Opin Otolaryngol 2004;12:431-8.

Wenzel GI, Pikkula B, Choi C-H, Anvari B, Oghalai JS. Laser irradiation of the guinea pig basilar membrane. Lasers Surg Med 2004;35:174-80.

Bloch DC, Oghalai JS, Jackler RK, Osofsky M, Pitts LH. The fate of the tumor remnant following less than complete acoustic neuroma resection. Otolaryngol Head Neck Surg 2004;130:104-12.

Lau C, Oghalai JS, Jackler RK. Combination of aberrant internal carotid artery and persistent stapedial artery. Otol Neurotol 2004;25:850-1.

Oghalai JS, Leung M-K, Jackler RK, McDermott MW. The transjugular craniotomy in the management of jugular foramen tumors with intracranial extension. Otol Neurotol 2004;25:570-9.

McMurphy AB, Oghalai JS. Repair of iatrogenic temporal lobe encephalocele following canal wall down mastoidectomy in the presence of active cholesteatoma. Otol Neurotol 2004;26:587-94.

Oghalai JS, Ramirez AL, Hegarty JL, Jackler RK. Chronic pachymeningitis presenting as asymmetric sensorineural hearing loss. Otol Neurotol 2004;25:616-21.

Oghalai JS. Chlorpromazine inhibits cochlear function in guinea pigs. Hear Res 2004;198:59-68.

Oghalai JS, Buxbaum JL, Pitts LH, Jackler RK. The effect of age on acoustic neuroma surgery outcomes. Otol Neurotol 2003;24:473-7.

Oghalai JS, Jackler RK. Anatomy of the combined retrolabyrinthine-middle fossa craniotomy. Neurosurg Focus 2003;14:1-4.

Yates PD, Jackler RK, Satar B, Pitts LH, Oghalai JS. Is it worthwhile to attempt hearing preservation in larger acoustic neuromas? Otol Neurotol 2003;24:460-4.

Oghalai JS, Chen L, Brennan ML, Tonini R, Manolidis S. Neonatal hearing loss in the indigent. Laryngoscope 2002;112;281-6.

Satar B, Jackler RK, Oghalai JS, Pitts LH, Yates PD. Risk-benefit analysis of using the middle fossa approach for acoustic neuromas with >10mm cerebellopontine angle component. Laryngoscope 2002;112:1500-6.

Jackler RK, Oghalai JS. Limitations to mobilizing the intrapetrous carotid artery. Ann Otol Rhinol Laryngol 2002;11:860.

Oghalai JS. Aspiration of a dental appliance in a patient with Alzheimer disease. JAMA 2002;288:2543-4.

Nguyen TU, Oghalai JS, MacGregor DK, Janssen N, Huston DP. Subcutaneous nodular amyloidosis: a case report and review of the literature. Hum Pathol 2001;32:346-8.

Oghalai JS, Holt JR, Jung TM, Nakagawa T, Coker NJ, Jenkins HA, Eatock RA, Brownell WE. Harvesting human hair cells. Ann Otol Rhinol Laryngol 2000;109:9-16.

Oghalai JS, Zhao HB, Kutz JW, Brownell WE. Voltage and tension-dependent lipid mobility in the outer hair cell plasma membrane. Science 2000;287:658-61.

Oghalai JS, Manolidis S, Barth JL, Stewart MG, Jenkins HA. Unrecognized benign paroxysmal positional vertigo in elderly patients . Otolaryngol Head Neck Surg 2000;122:630-4.

Oghalai JS, Giannoni C, Donovan DT, Johnson PE, Green LK. Aggressive cervical lymphoma presenting as airway obstruction. Otolaryngol Head Neck Surg 1999;120:610-3.

Oghalai JS, Tran TD, Raphael RM, Nakagawa T, Brownell WE. Transverse and lateral mobility in outer hair cell lateral wall membranes. Hear Res 1999;135:19-28.

Oghalai JS, Holt JR, Jung TM, Nakagawa T, Coker NJ, Jenkins HA, Eatock RA, Brownell WE. Ionic currents and electromotility in inner ear hair cells from humans. J Neurophysiol 1998;79:2235-9.

Oghalai JS, Patel AA, Nakagawa T, Brownell WE. Fluorescence-imaged microdeformation of the outer hair cell lateral wall. J Neurosci 1998;18:48-58.

Higgins JJ, Ide SE, Oghalai JS, Polymeropoulos MH. Lack of mutations in the biotin-binding region of the pyruvate carboxylase (PC) gene in a family with partial PC deficiency. Clin Biochem 1997;30:79-81.

Oghalai JS, Favrot S, Coker NJ. Imaging quiz case 2: Post-traumatic middle ear mass. Arch Otolaryngol Head Neck Surg 1996;122:1267-8.

Oghalai JS, Street WN, Rhode WS. A neural network based spike discriminator. J Neurosci Methods 1994;54:9-22.

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©2001-2007 Baylor College of Medicine
Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery
Mail: One Baylor Plaza, NA102, Houston, TX 77030
Phone: 713-798-5906
E-mail: oto@bcm.edu

Last modified: June 15, 2007