Salama A. Salama, Ph.D., Assitant Professor
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Baylor College of Medicine |
Dr. Salama recieved his B.S. in Pharmacy and Pharmaceutical Science from Al-Azhar University, Faculty of Pharmacy, Cairo, Egypt. He then proceeded to obtain his M.S. in Pharmacology and Experimental Therapeutics, from Al-Azhar University, FAculty of Pharmacy, in Cairo, Egypt. He earned his Ph.D. in Pharmacogenetics and Genetic Toxicology, University of Texas Medical Branch at Galveston and Al-Azhar University, Cairo Egypt (under the channel system and joint supervision scheme).
Dr. Salama's research focuses on studying estrogen biosynthesis and metabolism, elucidating the transcription regulation of estrogen-metabolizing genes, profile of estrogen metabolites and estrogen-induced adducts, in hormone-dependent human diseases such as breast cancer, endometrial cancer and uterine fibroids. From our previous study of estrogen metabolites, we have demonstrate the potential capacity of estrogen and certain estrogen metabolites to induce oxidative stress, mutagenic DNA adducts formation, genomic instability, and neoplastic transformation, of human endometrial glandular cells. Recently, we demonstrated that natural estrogen metabolites 2-methoxyestradiol represents a potential new therapeutic for uterine leiomyomas. Directing estrogen metabolism to form 2-methoxyestradiol by regulating the expression of Catechol-O-methyltransferase or affects microtubule dynamics, ameliorates cell proliferation, inhibits steroid receptors signaling, and reduces HIF-1 α and CYP19 expression in human uterine leiomyoma cells.
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