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Department of Neurosurgery

Houston, Texas

Department of Neurosurgery
Department of Neurosurgery
not shown on screen

H. David Shine, Ph.D.

Associate Professor
Associate Professor - Secondary Appointment, Department of Neuroscience
Associate Professor - Secondary Appointment, Department of Molecular and Cell Biology
Associate Member - Center for Cell and Gene Therapy

Undergraduate School
Texas Tech University, Lubbock, Texas; University of Texas, Austin, Texas

Ph.D.
University of Texas, Austin, Texas

Postgraduate
Harvard Medical School, Boston, Massachusetts

Primary Neurosurgical Interests
Research: Molecular neurobiology; nervous system regenration, gene therapy of the nervous system

Professional Associations
American Society for Neurochemistry
Society for Neuroscience
Sigma XI
International Society for Neurochemistry
International Society for developmental Neuroscience
American Association for the Advancement of Science
Neurotrauma Society
American Society of Gene Therapy
American Society for Peripheral Nerve

Contact Information
Alkek Building
One Baylor Plaza, Room N1130
Houston, TX 77030
Phone: 713-798-3828
Fax: 713-798-1230

Selected Publications

Baumgartner BJ, Shine HD: Neuroprotection of CNS neuron by retrograde transport of adenoviral vectors carrying neurotrophic genes. Journal of Neuroscience 17:6504-6511, 1997.

Trask TW, Trask RP, Aguilar-Cordova E, Shine HD, Wyde PR, Goodman JC, Hamilton WJ, Rojas-Martinez A, Chen S-H, Woo SLC, Grossman RG: Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with recurrent malignant brain tumors. Mol. Med. 1:195-203, 2000.

Castro RF, Jackson KA, Goodell MA, Robertson CS, Liu H, Shine HD: Failure of bone marrow cells to transdifferentiate into neural cells in vivo. Science 297:1299, 2002.

Zhou L, Baumgartner BJ, Hill-Felberg SJ, McGowen LR and Shine HD: Neurotrophin-3 expressed in situ induces axonal plasticity in the adult injured spinal cord. J. Neurosci. 23:1424-1431, 2003.

Grider MH, Mamounas LA, Le W, Shine HD: In situ expression of brain-derived neurotrophic factor or neurotrophin-3 promotes sprouting o fcortical serotonergic axons following a neurotoxic lesion. J. Neurosci Res 82:404-412, 2005.