Multiple Sclerosis Research Laboratory
Jian Hong, M.D., Ph.D.
Sheri M. Skinner, Ph.D.
Ying “Crystal” Zang, M.D., Ph.D.
Rana Singh, Ph.D.
Xin “Cindy” Liu, B.S.
Our multi-disciplinary research program is focused on the autoimmune mechanisms involved in the pathogenesis of multiple sclerosis (MS) and the development of novel approaches for its treatment.
The research combines immunologic and molecular biologic techniques to investigate the mechanisms underlying the aberrant activation and migration of autoimmune T cells recognizing myelin self-antigens in MS. Special emphasis is placed upon the regulation of detrimental myelin-specific T cells through mechanisms involving regulatory T cells and cytokine networks. Another important element of the research is to define the structural and functional properties of myelin-reactive T cells and their relevance to the pathogenesis of MS. Our research takes several independent directions, resulting in data that combines to form a more complete picture of immunological balance mechanisms involved in amelioration of multiple sclerosis symptoms.
It is hoped that the basic science research will help us to better understand the autoimmune mechanisms involved in the pathogenesis of MS, and may eventually lead to the development of more effective immunotherapies.
Multiple Sclerosis Research Laboratory
Department of Neurology
Baylor College of Medicine
Neurosensory Center
6501 Fannin, Suite NB302
Houston, Texas 77030
Tel: 713-798-3975
Fax: 713-798-5665Click here for Maps & Directions | Interactive Map (#22)