Yi Zhang, M.D., Ph.D.
Instructor of Neurology
Medical School
M.D. (1985) Zhejiang Medical University
Graduate School
Ph.D. (1999) University of Kentucky
Research Interests
To explore the roles of voltage-dependent ion channels in the mechanisms underlying epileptogenesis of inherited and acquired seizures using various animal models (such as single gene mutant models as well as drug induced ones). Patch-clamp electrophysiological recording and methods of molecular biology are used to ascertain the addressed research questions. My long term research goal will be targeted to investigating the mechanisms involving ion-channel related epilepsy and neurological disorders.
Publications
- Zhang Y, Vilaythong AP, Yoshor D, Noebels JL. Elevated thalamic low-voltage-activated currents precede the onset of absence epilepsy in the SNAP25-deficient mouse mutant coloboma. J Neurosci 2004;24:5239-48.
- Zhang Y, Mori M, Burgess DL, Noebels JL. Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons. J Neurosci 2002;22:6362-71.
- Zhang Y, Cribbs LL, Satin J. Arachidonic acid modulation of alpha1H, a cloned human T-type calcium channel. Am J Physiol Heart Circ Physiol 2000;278:H184-93.
- Zhang Y, Hartmann HA, Satin J. Glycosylation influences voltage-dependent gating of cardiac and skeletal muscle sodium channels. J Membr Biol 1999;171:195-207.
- Cribbs LL, Lee JH, Yang J, Satin J, Zhang Y, Daud A, Barclay J, Williamson MP, Fox M, Rees M, Perez-Reyes E. Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family. Circ Res 1998;83:103-9.
- Zhang Y, Richardson D, McCray A. Role of nitric oxide in the response of capillary blood flow in the rat tail to body heating. Microvasc Res 1994;47:177-87.
Contact Information
Yi Zhang, M.D., Ph.D.
Department of Neurology
Baylor College of Medicine
One Baylor Plaza, MS NB302
Houston, Texas 77030
Tel: 713-798-8772
Fax: 713-798-7528
Email: