Wenjie Xie, M.D.

Instructor of Neurology

Medical School

M.D. (1978) Suzhou Medical College, China

Research Interests

The celluar and molecular investigation using cultures, cell line and animal models to define the pathogenic mechanisms of Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis.

Publications
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Deng H, Le W, Shahed J, Xie W, Jankovic J. Mutation analysis of the parkin and PINK1 genes in American Caucasian early-onset Parkinson disease families. Neurosci Lett 2008;430:18-22.
Zhu W, Xie W, Pan T, Jankovic J, Li J, Youdim MB, Le W. Comparison of neuroprotective and neurorestorative capabilities of rasagiline and selegiline against lactacystin-induced nigrostriatal dopaminergic degeneration. J Neurochem 2008;105:1970-8.
Deng H, Le W, Huang M, Xie W, Pan T, Jankovic J. Genetic analysis of LRRK2 P755L variant in Caucasian patients with Parkinson's disease. Neurosci Lett 2007;419:104-7.
Deng H, Le WD, Hunter CB, Mejia N, Xie WJ, Jankovic J. A family with Parkinson disease, essential tremor, bell palsy, and parkin mutations. Arch Neurol 2007;64:421-4.
Qu S, Le W, Zhang X, Xie W, Zhang A, Ondo WG. Locomotion is increased in a11-lesioned mice with iron deprivation: a possible animal model for restless legs syndrome. J Neuropathol Exp Neurol 2007;66:383-8.
Xiao Q, Zhao W, Beers DR, Yen AA, Xie W, Henkel JS, Appel SH. Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia. J Neurochem 2007;102:2008-19.
Zhao H, Zhu W, Pan T, Xie W, Zhang A, Ondo WG, Le W. Spinal cord dopamine receptor expression and function in mice with 6-OHDA lesion of the A11 nucleus and dietary iron deprivation. J Neurosci Res 2007;85:1065-76.
Zhu W, Xie W, Pan T, Xu P, Fridkin M, Zheng H, Jankovic J, Youdim MB, Le W. Prevention and restoration of lactacystin-induced nigrostriatal dopamine neuron degeneration by novel brain-permeable iron chelators. Faseb J 2007;21:3835-44.
Deng H, Le W, Davidson AL, Xie W, Jankovic J. The LRRK2 I2012T, G2019S and I2020T mutations are not common in patients with essential tremor. Neurosci Lett 2006;407:97-100.
Deng H, Le W, Guo Y, Hunter CB, Xie W, Huang M, Jankovic J. Genetic analysis of LRRK2 mutations in patients with Parkinson disease. J Neurol Sci 2006;251:102-6.
Deng H, Le WD, Hunter CB, Ondo WG, Guo Y, Xie WJ, Jankovic J. Heterogeneous phenotype in a family with compound heterozygous parkin gene mutations. Arch Neurol 2006;63:273-7.
Deng H, Le WD, Xie WJ, Jankovic J. Examination of the SLITRK1 gene in Caucasian patients with Tourette syndrome. Acta Neurol Scand 2006;114:400-2.
Deng H, Xie W, Guo Y, Le W, Jankovic J. Gene dosage analysis of alpha-synuclein (SNCA) in patients with Parkinson's disease. Mov Disord 2006;21:728-9.
Deng H, Xie WJ, Le WD, Huang MS, Jankovic J. Genetic analysis of the GABRA1 gene in patients with essential tremor. Neurosci Lett 2006;401:16-9.
Moore DD, Kato S, Xie W, Mangelsdorf DJ, Schmidt DR, Xiao R, Kliewer SA. International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor. Pharmacol Rev 2006;58:742-59.
Qu S, Ondo WG, Zhang X, Xie WJ, Pan TH, Le WD. Projections of diencephalic dopamine neurons into the spinal cord in mice. Exp Brain Res 2006;168:152-6.
Zhao W, Xie W, Xiao Q, Beers DR, Appel SH. Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia. J Neurochem 2006;99:1176-87.
Deng H, Jankovic J, Guo Y, Xie W, Le W. Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y. Biochem Biophys Res Commun 2005;337:1133-8.
Deng H, Le W, Guo Y, Hunter CB, Xie W, Jankovic J. Genetic and clinical identification of Parkinson's disease patients with LRRK2 G2019S mutation. Ann Neurol 2005;57:933-4.
Deng H, Le WD, Guo Y, Huang MS, Xie WJ, Jankovic J. Extended study of A265G variant of HS1BP3 in essential tremor and Parkinson disease. Neurology 2005;65:651-2.
Deng H, Le WD, Xie WJ, Pan TH, Zhang X, Jankovic J. Genetic analysis of parkin co-regulated gene (PACRG) in patients with early-onset parkinsonism. Neurosci Lett 2005;382:297-9.
Imam SZ, Jankovic J, Ali SF, Skinner JT, Xie W, Conneely OM, Le WD. Nitric oxide mediates increased susceptibility to dopaminergic damage in Nurr1 heterozygous mice. Faseb J 2005;19:1441-50.
Pan T, Li X, Xie W, Jankovic J, Le W. Valproic acid-mediated Hsp70 induction and anti-apoptotic neuroprotection in SH-SY5Y cells. FEBS Lett 2005;579:6716-20.
Pan T, Xie W, Jankovic J, Le W. Biological effects of pramipexole on dopaminergic neuron-associated genes: relevance to neuroprotection. Neurosci Lett 2005;377:106-9.
Zhang X, Xie W, Qu S, Pan T, Wang X, Le W. Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration. Biochem Biophys Res Commun 2005;333:544-9.
Zhao W, Xie W, Le W, Beers DR, He Y, Henkel JS, Simpson EP, Yen AA, Xiao Q, Appel SH. Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism. J Neuropathol Exp Neurol 2004;63:964-77.
Le W, Rowe D, Xie W, Ortiz I, He Y, Appel SH. Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease. J Neurosci 2001;21:8447-55.
Le WD, Jankovic J, Xie W, Appel SH. Antioxidant property of pramipexole independent of dopamine receptor activation in neuroprotection. J Neural Transm 2000;107:1165-73.
Le WD, Rowe DB, Jankovic J, Xie W, Appel SH. Effects of cerebrospinal fluid from patients with Parkinson disease on dopaminergic cells. Arch Neurol 1999;56:194-200.
Le WD, Xie WJ, Appel SH. Protective role of heme oxygenase-1 in oxidative stress-induced neuronal injury. J Neurosci Res 1999;56:652-8.
Zou L, Jankovic J, Rowe DB, Xie W, Appel SH, Le W. Neuroprotection by pramipexole against dopamine- and levodopa-induced cytotoxicity. Life Sci 1999;64:1275-85.
Chen S, Le WD, Xie WJ, Alexianu ME, Engelhardt JI, Siklos L, Appel SH. Experimental destruction of substantia nigra initiated by Parkinson disease immunoglobulins. Arch Neurol 1998;55:1075-80.
Colom LV, Diaz ME, Beers DR, Neely A, Xie WJ, Appel SH. Role of potassium channels in amyloid-induced cell death. J Neurochem 1998;70:1925-34.
Colom LV, Neely A, Diaz ME, Xie WJ, Appel SH. Modulation of septal cell activity by extracellular zinc. Neuroreport 1997;8:3081-6.
Kalman J, Engelhardt JI, Le WD, Xie W, Kovacs I, Kasa P, Appel SH. Experimental immune-mediated damage of septal cholinergic neurons. J Neuroimmunol 1997;77:63-74.
Le W, Jankovic J, Xie W, Kong R, Appel SH. (-)-Deprenyl protection of 1-methyl-4 phenylpyridium ion (MPP+)-induced apoptosis independent of MAO-B inhibition. Neurosci Lett 1997;224:197-200.
Le WD, Xie WJ, Kong R, Appel SH. Beta-amyloid-induced neurotoxicity of a hybrid septal cell line associated with increased tau phosphorylation and expression of beta-amyloid precursor protein. J Neurochem 1997;69:978-85.
Le W, Xie WJ, Nyormoi O, Ho BK, Smith RG, Appel SH. beta-Amyloid1-40 increases expression of beta-amyloid precursor protein in neuronal hybrid cells. J Neurochem 1995;65:2373-6.
Le WD, Colom LV, Xie WJ, Smith RG, Alexianu M, Appel SH. Cell death induced by beta-amyloid 1-40 in MES 23.5 hybrid clone: the role of nitric oxide and NMDA-gated channel activation leading to apoptosis. Brain Res 1995;686:49-60.
Le WD, Engelhardt J, Xie WJ, Schneider L, Smith RG, Appel SH. Experimental autoimmune nigral damage in guinea pigs. J Neuroimmunol 1995;57:45-53.
Le WD, Xie WJ, Smith RG, Appel SH. Vimentin-crossreactive antibodies induce cell death in primary cultures of embryonic spinal cord. J Neuroimmunol 1993;42:15-22.
Crawford GD, Jr., Le WD, Smith RG, Xie WJ, Stefani E, Appel SH. A novel N18TG2 x mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin. J Neurosci 1992;12:3392-8.

Poster Presentations
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Le W, Nguyen D, Lin W, Rawal P, Ding Y, Xie W, Deng H, Jankovic J. Transcription factor PITX3 in Parkinson's disease. Mov Disord. 2009;24 Suppl 1:S143.
Pan T, Xie W, Jankovic J, Le W. 17-AAG protects against rotenone-induced apoptosis in SHSY5Y cells via HSP70 induction. Mov Disord. 2009;24 Suppl 1:S361.
Pan T, Xie W, Le W, Jankovic J. Resveratrol, a polyphenol found in red wine, protects against rotenone-induced apoptosis through autophagy induction. Mov Disord. 2009;24 Suppl 1:S225-6.
Pan T, Xie W, Rawal P, Jankovic J, Le W. Rapamycin protects against rotenone-induced apoptosis through autophagy induction in SH-SY5Y cells. Neurology. 2009;72(11 Suppl 3):A438-9.
Le WD, Pan T, Xie W, Huang M, Xu P, Zhu W, Zhang X, Deng H, Jankovic J. Expanded study of NURR1 gene expression in patients with Parkinson's disease. Mov Disord. 2008;23 Suppl 1:S36.
Lou FF, Zhu W, Xie W, Ondo W, Le W. Short-term and long-term improvement by pramipexole in restless leg syndrome animal model. Ann Neurol. 2008;64 Suppl 12:S54.
Pan T, Li X, Xie W, Jankovic J, Le WD. Role of deferoxamine and autophagy induction in rotenone-induced apoptosis. Neurology. 2008;70(11 Suppl 1):A325-7.
Pan T, Xie W, Jankovic J, Le WD. Rapamycin rescues lactacystin-induced dopaminergic neuron injury in vivo. Mov Disord. 2008;23 Suppl 1:S23.
Xie W, Zhu W, Pan T, Jankovic J, Le W. Progressive DA neuron degeneration induced by targeting administration of proteasome inhibitor in SN. Ann Neurol. 2008;64 Suppl 12:S46-7.
Pan T, Li X, Zhu W, Xie W, Jankovic J, Le W. Autophagy induction and its neuroprotection on neurotoxin-induced cell injury relevant to Parkinson's disease. Neurology. 2007;68(12 Suppl 1):A111.
Zhu W, Pan T, Xie W, Jankovic J, Zheng H, Youdim M, Le W. Brain permeable iron chelators M-30 and AK-28 rescue degenerated nigral dopamine neurons in animal model of PD. Mov Disord. 2007:22 Suppl 16:S201.
Zhu W, Pan T, Xie W, Xu P, Jankovic J, Youdim MBH, Le W. Comparison of neuroprotective and neurorescue capabilities of rasagiline and selegiline, against lactacystin induced nigrostriatal degeneration. Neurodegener Dis. 2007;4 Suppl 1:90.
Zhu W, Pan T, Xie W, Xu P, Zheng H, Fridkin M, Jankovic J, Youdim MBH, Le W. Novel brain permeable iron chelators prevent lactacystin induced ubiquitn-proteasome inhibition and degeneration of nigrostrialtal dopamine neurons. Neurology. 2007;68(12 Suppl 1):A113.
Zhu W, Pan T, Zhang X, Xie W, Jankovic J, Le W. Proteasome inhibition in substantial nigra induces sustained dopamine cells degeneration. Neurology. 2007;68(12 Suppl 1):A111.
Deng H, Le W, Davidson AL, Xie W, Jankovic J. Examination of LRRK2 I2012T, G2019S, and I2020T mutations in patients with essential tremor. Mov Disord. 2006;21 Suppl 15:S704.
Deng H, Le W, Guo Y, Hunter CB, Xie W, Huang M, Jankovic J. Examination of LRRK2 I2012T, G2019S, and I2020T mutations in patients with essential tremor. Ann Neurol. 2006;60 Suppl 10:S74.
Deng H, Le W, Hunter CB, Xie W, Mejia N, Jankovic J. A Mexican pedigree with Parkinson's disease, essential tremor and bell's palsy associated with parkin but not HS1BP3 gene mutation. Ann Neurol. 2006;60 Suppl 10:S58.
Deng H, Le W, Xie W, Jankovic J. Genetic analysis of the SLITRK1 gene in caucasian patients with Tourette syndrome. Ann Neurol. 2006;60 Suppl 10:S74.
Pan T, Kondo S, Zhu W, Xie W, Jankovic J, Le W. Enhancement of autophagy and neuroprotection by rapamycin in lactacystin-induced injury of dopaminergic neurons. Mov Disord. 2006;21 Suppl 15:S505.
Pan T, Xie W, Deng H, Zhao H, Jankovic J. Nurrl deficiency predisposes to apoptosis induced by lactacystin in SH-SY5Y cells in vitro. Neurology. 2006;66(5 Suppl 2):A142.
Zhao H, Zhu W, Pan T, Xie W, Ondo W, Le W. Spinal cord dopamine receptor expression and function in mice with 6-OHDA lesion of the A11 nucleus and dietary iron deprivation. Mov Disord. 2006;21 Suppl 15:S341.
Deng H, Jankovic J, Pan T, Xie W, Le W. Small interfering RNA (SiRNA) targeting the PINK1 induces apoptosisin human SH-SY5Y cells. Mov Disord. 2005:20 Suppl 10:S127.
Deng H, Jankovic J, Xie W, Pan T, Le W. Reduced NURR1 gene expression affects expression of dopaminergic phenotypic markers and Parkinson's disease-related genes. Mov Disord. 2005:20 Suppl 10:S143.
Pan T, Xie W, Jankovic J, Le W. HSP70 inducer VPA inhibits rotenone-induced apoptosis in SH-SY5Y cells. Neurology. 2005;64(6 Suppl 1):A199.
Le W, Jiang Q, Xie W, Hintermann S, Jankovic J. Nurr1 gene targeting therapy for Parkinson disease. Mov Disord. 2004:19 Suppl 9:S132.
Pan T, Xie W, Jankovic J, Le W. Decreased Nurr1 mRNA in peripheral blood lymphocytes in Parkinson's disease. Neurology. 2004:62(7 Suppl S5):A108.
Pan T, Xie W, Jankovic J, Le W. The pharmacological and biological effects of pramipexole on dopamine neuron associated genes: DAT, VMAT-2, and Nurr1. Mov Disord. 2004:19 Suppl 9:S215.
Le W, Imam SZ, Xie W, Ali S, Jankovic J. Reduced Nurr1 expression increases the susceptibility to dopaminergic toxins via nitric oxide. Mov Disord. 2002:17 Suppl 5:S27.
Pan TH, Xu PY, Xie WJ, Hunter C, Jankovic J, Le WD. Upregulation of Nurr1 gene expression by dopamine receptor agonist pramipexole in human neuroblastoma SHSY-5Y cells. Mov Disord. 2002:17 Suppl 5:S84.

Contact Information

Wenjie Xie, M.D.
Department of Neurology
Baylor College of Medicine
One Baylor Plaza, MS NB302
Houston, Texas 77030

Tel: 713-798-5142
Fax: 713-798-8307
Email: