Dennis R. Mosier, M.D., Ph.D.
Associate Professor of Neurology
Clinical Service Area
Neurology
Specialty
Muscular Dystrophy
Board Certification
American Board of Psychiatry and Neurology, Neurology
Clinic Appointments
713-798-4227
Consult
713-798-4227
Medical School
M.D./Ph.D., University of Florida College of Medicine, Gainesville, FL
Internship
Internal Medicine, Baylor College of Medicine, Houston, TX
Residency
Neurology, Baylor College of Medicine, Houston, TX
Clinical Interests
Neuromuscular disorders such as amyotrophic lateral sclerosis (Lou Gehrig's disase), myasthenia gravis, and muscle diseases, neurodegenerative diseases
Clinic Location
Baylor Neurology
Smith Tower
6550 Fannin, Suite 1801
Houston, Texas 77030
Journal Publications
- Orengo JP, Chambon P, Metzger D, Mosier DR, Snipes GJ, Cooper TA. Expanded CTG repeats within the DMPK 3' UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy. Proc Natl Acad Sci U S A. 2008;105:2646-51.
- Kawai M, Gundogdu B, Kwan J, Mosier DR. Inflammatory cells invading non-necrotic muscle fibers in myotonic dystrophy type 2. J Clin Neuromuscular Dis. 2007;8:212-6.
- Deitiker PR, Oshima M, Smith RG, Mosier DR, Atassi MZ. Subtle differences in HLA DQ haplotype-associated presentation of AChR alpha-chain peptides may suffice to mediate myasthenia gravis. Autoimmunity. 2006;39:277-88.
- Jha S, Xu K, Maruta T, Oshima M, Mosier DR, Atassi MZ, Hoch W. Myasthenia gravis induced in mice by immunization with the recombinant extracellular domain of rat muscle-specific kinase (MuSK). J Neuroimmunol. 2006;175:107-17.
- Oshima M, Maruta T, Ohtani M, Deitiker PR, Mosier D, Atassi MZ. Vaccination with a MHC class II peptide in Alum and inactive pertussis strongly ameliorates clinical MG in C57BL/6 mice. J Neuroimmunol. 2006;171:8-16.
- Oshima M, Deitiker PR, Mosier DR, Smith RG, Atassi MZ. Responses in vitro of peripheral blood lymphocytes from patients with myasthenia gravis to stimulation with human acetylcholine receptor alpha-chain peptides: analysis in relation to age, thymic abnormality, and ethnicity. Hum Immunol. 2005;66:32-42.
- Oshima M, Ohtani M, Deitiker PR, Smith RG, Mosier DR, Atassi MZ. Suppression by mAbs against DQB1 peptides of in vitro proliferation of AChR-specific T cells from myasthenia gravis patients. Autoimmunity. 2005;38:161-9.
- Wang P, Yang G, Mosier DR, Chang P, Zaidi T, Gong YD, Zhao NM, Dominguez B, Lee KF, Gan WB, Zheng H. Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2. J Neurosci. 2005;25:1219-25.
- Quattrocchi CC, Huang C, Niu S, Sheldon M, Benhayon D, Cartwright J, Jr., Mosier DR, Keller F, D'Arcangelo G. Retraction. Science. 2004;303:1974.
- Quattrocchi CC, Huang C, Niu S, Sheldon M, Benhayon D, Cartwright J, Jr., Mosier DR, Keller F, D'Arcangelo G. Reelin promotes peripheral synapse elimination and maturation. Science. 2003;301:649-53.
- Mohamed HA, Mosier DR, Zou LL, Siklos L, Alexianu ME, Engelhardt JI, Beers DR, Le WD, Appel SH. Immunoglobulin Fc gamma receptor promotes immunoglobulin uptake, immunoglobulin-mediated calcium increase, and neurotransmitter release in motor neurons. J Neurosci Res. 2002;69:110-6.
- Simpson EP, Mosier D, Appel SH. Mechanisms of disease pathogenesis in amyotrophic lateral sclerosis. A central role for calcium. Adv Neurol. 2002;88:1-19.
- Appel SH, Beers D, Siklos L, Engelhardt JI, Mosier DR. Calcium: the Darth Vader of ALS. Amyotroph Lateral Scler Other Motor Neuron Disord. 2001;2 Suppl 1:S47-54.
- Beers DR, Ho BK, Siklos L, Alexianu ME, Mosier DR, Mohamed AH, Otsuka Y, Kozovska ME, McAlhany RE, Smith RG, Appel SH. Parvalbumin overexpression alters immune-mediated increases in intracellular calcium, and delays disease onset in a transgenic model of familial amyotrophic lateral sclerosis. J Neurochem. 2001;79:499-509.
- Gooch CL, Mosier DR. Stimulated single fiber electromyography in the mouse: techniques and normative data. Muscle Nerve. 2001;24:941-5.
- Mosier DR, Siklos L, Appel SH. Resistance of extraocular motoneuron terminals to effects of amyotrophic lateral sclerosis sera. Neurology. 2000;54:252-5.
- Le W, Conneely OM, Zou L, He Y, Saucedo-Cardenas O, Jankovic J, Mosier DR, Appel SH. Selective agenesis of mesencephalic dopaminergic neurons in Nurr1-deficient mice. Exp Neurol. 1999;159:451-8.
- Colom LV, Alexianu ME, Mosier DR, Smith RG, Appel SH. Amyotrophic lateral sclerosis immunoglobulins increase intracellular calcium in a motoneuron cell line. Exp Neurol. 1997;146:354-60.
- Smith RG, Siklos L, Alexianu ME, Engelhardt JI, Mosier DR, Colom L, Habib Mohamed A, Appel SH. Autoimmunity and ALS. Neurology. 1996;47:S40-5; discussion S45-6.
- Mosier DR, Baldelli P, Delbono O, Smith RG, Alexianu ME, Appel SH, Stefani E. Amyotrophic lateral sclerosis immunoglobulins increase Ca2+ currents in a motoneuron cell line. Ann Neurol. 1995;37:102-9.
- Appel SH, Smith RG, Alexianu M, Engelhardt J, Mosier D, Colom L, Stefani E. Neurodegenerative disease: autoimmunity involving calcium channels. Ann N Y Acad Sci. 1994;747:183-94.
- Mosier DR, Zengel JE. Evoked transmitter release at the frog neuromuscular junction in the presence of very low extracellular Ca2+. Neurosci Lett. 1994;174:1-4.
- Zengel JE, Sosa MA, Poage RE, Mosier DR. Role of intracellular Ca2+ in stimulation-induced increases in transmitter release at the frog neuromuscular junction. J Gen Physiol. 1994;104:337-55.
- Zengel JE, Lee DT, Sosa MA, Mosier DR. Effects of calcium channel blockers on stimulation-induced changes in transmitter release at the frog neuromuscular junction. Synapse. 1993;15:251-62.
Poster and Platform Presentations
- Mosier D, Smith R. Searching for unicorns: The neurologist as diagnostician for rare disorders. Neurology. 2009;72(11 Suppl 3):A209.
- Nord K, Mosier D. Myasthenia mimics. J Clin Neuromuscular Disease. 2009;10:156.
- Shanina E, Mosier D, Smith RG. Motor neuropathy in Fascioscapulohumeral Dystrophy (FSHD). Ann Neurol. 2009;66 Suppl 13:S23.
Contact Information
Dennis R. Mosier, M.D., Ph.D.
Department of Neurology
Baylor College of Medicine
One Baylor Plaza, MS NB302
Houston, Texas 77030
Tel: 713-798-4227
Fax: 713-798-3091
Email: