Weidong Le, M.D., Ph.D.

Professor of Neurology

Co-Director, Parkinson's Disease Research Laboratory

Medical School

M.D., Suzhou Medical College, China

Graduate School

Ph.D., Shanghai Second Medical University, China

Clinical Interests

Neurodegenerative diseases: Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis

Research Interests

Cellular and molecular basis of neuronal injury in these neurodegenerative diseases. Main focuses are genetic and environmental factors contributing to nigral dopamine neuron degeneration, and novel target therapy for Parkinson's disease and other movement disorders. Other research interests also include the role of oxidative stress and inflammatory in ß-amyloid metabolism relevant to Alzheimer's disease; and dysfunction of diencephalic-spinal cord dopaminergic pathway in restless leg syndrome.

Journal Publications
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Guo Y, Jankovic J, Zhu S, Le W, Song Z, Xie W, Liao D, Yang H, Deng H. GIGYF2 Asn56Ser and Asn457Thr mutations in Parkinson disease patients. Neurosci Lett. 2009;454:209-11.

Le W, Chen S, Jankovic J. Etiopathogenesis of Parkinson disease: a new beginning? Neuroscientist. 2009;15:28-35.

Le W, Nguyen D, Lin XW, Rawal P, Huang M, Ding Y, Xie W, Deng H, Jankovic J. Transcription factor PITX3 gene in Parkinson's disease. Neurobiol Aging. 2009;:.

Pan T, Rawal P, Wu Y, Xie W, Jankovic J, Le W. Rapamycin protects against rotenone-induced apoptosis through autophagy induction. Neuroscience. 2009;164:541-51.

Walters AS, Ondo WG, Zhu W, Le W. Does the endogenous opiate system play a role in the Restless Legs Syndrome? A pilot post-mortem study. J Neurol Sci. 2009;279:62-5.

Deng H, Le W, Shahed J, Xie W, Jankovic J. Mutation analysis of the parkin and PINK1 genes in American Caucasian early-onset Parkinson disease families. Neurosci Lett. 2008;430:18-22.

Deng H, Le WD, Jankovic J. Genetic study of an American family with DYT3 dystonia (lubag). Neurosci Lett. 2008;448:180-3.

Le W, Pan T, Huang M, Xu P, Xie W, Zhu W, Zhang X, Deng H, Jankovic J. Decreased NURR1 gene expression in patients with Parkinson's disease. J Neurol Sci. 2008;273:29-33.

Li X, Du Y, Fan X, Yang D, Luo G, Le W. c-Jun N-terminal kinase mediates lactacystin-induced dopamine neuron degeneration. J Neuropathol Exp Neurol. 2008;67:933-44.

Pan T, Kondo S, Le W, Jankovic J. The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease. Brain. 2008;131:1969-78.

Pan T, Kondo S, Zhu W, Xie W, Jankovic J, Le W. Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement. Neurobiol Dis. 2008;32:16-25.

Pan T, Zhu W, Zhao H, Deng H, Xie W, Jankovic J, Le W. Nurr1 deficiency predisposes to lactacystin-induced dopaminergic neuron injury in vitro and in vivo. Brain Res. 2008;1222:222-9.

Pu P, Le W. Dopamine neuron degeneration induced by MPP(+) is independent of CED-4 pathway in Caenorhabditis elegans. Cell Res. 2008;:.

Wang W, Le WD, Pan T, Stringer JL, Jaiswal AK. Association of NRH:quinone oxidoreductase 2 gene promoter polymorphism with higher gene expression and increased susceptibility to Parkinson's disease. J Gerontol A Biol Sci Med Sci. 2008;63:127-34.

Zhu W, Xie W, Pan T, Jankovic J, Li J, Youdim MB, Le W. Comparison of neuroprotective and neurorestorative capabilities of rasagiline and selegiline against lactacystin-induced nigrostriatal dopaminergic degeneration. J Neurochem. 2008;105:1970-8.

Deng H, Le W, Huang M, Xie W, Pan T, Jankovic J. Genetic analysis of LRRK2 P755L variant in Caucasian patients with Parkinson's disease. Neurosci Lett. 2007;419:104-7.

Deng H, Le W, Jankovic J. Genetics of essential tremor. Brain. 2007;130:1456-64.

Deng H, Le WD, Hunter CB, Mejia N, Xie WJ, Jankovic J. A family with Parkinson disease, essential tremor, bell palsy, and parkin mutations. Arch Neurol. 2007;64:421-4.

Ondo WG, Zhao HR, Le WD. Animal models of restless legs syndrome. Sleep Med. 2007;8:344-8.

Qu S, Le W, Zhang X, Xie W, Zhang A, Ondo WG. Locomotion is increased in a11-lesioned mice with iron deprivation: a possible animal model for restless legs syndrome. J Neuropathol Exp Neurol. 2007;66:383-8.

Zhao H, Zhu W, Pan T, Xie W, Zhang A, Ondo WG, Le W. Spinal cord dopamine receptor expression and function in mice with 6-OHDA lesion of the A11 nucleus and dietary iron deprivation. J Neurosci Res. 2007;85:1065-76.

Zhu W, Xie W, Pan T, Xu P, Fridkin M, Zheng H, Jankovic J, Youdim MB, Le W. Prevention and restoration of lactacystin-induced nigrostriatal dopamine neuron degeneration by novel brain-permeable iron chelators. Faseb J. 2007;21:3835-44.

Chu Y, Le W, Kompoliti K, Jankovic J, Mufson EJ, Kordower JH. Nurr1 in Parkinson's disease and related disorders. J Comp Neurol. 2006;494:495-514.

Deng H, Le W, Davidson AL, Xie W, Jankovic J. The LRRK2 I2012T, G2019S and I2020T mutations are not common in patients with essential tremor. Neurosci Lett. 2006;407:97-100.

Deng H, Le W, Guo Y, Hunter CB, Xie W, Huang M, Jankovic J. Genetic analysis of LRRK2 mutations in patients with Parkinson disease. J Neurol Sci. 2006;251:102-6.

Deng H, Le WD, Hunter CB, Ondo WG, Guo Y, Xie WJ, Jankovic J. Heterogeneous phenotype in a family with compound heterozygous parkin gene mutations. Arch Neurol. 2006;63:273-7.

Deng H, Le WD, Xie WJ, Jankovic J. Examination of the SLITRK1 gene in Caucasian patients with Tourette syndrome. Acta Neurol Scand. 2006;114:400-2.

Deng H, Xie W, Guo Y, Le W, Jankovic J. Gene dosage analysis of alpha-synuclein (SNCA) in patients with Parkinson's disease. Mov Disord. 2006;21:728-9.

Deng H, Xie WJ, Le WD, Huang MS, Jankovic J. Genetic analysis of the GABRA1 gene in patients with essential tremor. Neurosci Lett. 2006;401:16-9.

Qu S, Ondo WG, Zhang X, Xie WJ, Pan TH, Le WD. Projections of diencephalic dopamine neurons into the spinal cord in mice. Exp Brain Res. 2006;168:152-6.

Cai W, Khaoustov VI, Xie Q, Pan T, Le W, Yoffe B. Interferon-alpha-induced modulation of glucocorticoid and serotonin receptors as a mechanism of depression. J Hepatol. 2005;42:880-7.

Deng H, Jankovic J, Guo Y, Xie W, Le W. Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y. Biochem Biophys Res Commun. 2005;337:1133-8.

Deng H, Le W, Guo Y, Hunter CB, Xie W, Jankovic J. Genetic and clinical identification of Parkinson's disease patients with LRRK2 G2019S mutation. Ann Neurol. 2005;57:933-4.

Deng H, Le WD, Guo Y, Huang MS, Xie WJ, Jankovic J. Extended study of A265G variant of HS1BP3 in essential tremor and Parkinson disease. Neurology. 2005;65:651-2.

Deng H, Le WD, Xie WJ, Pan TH, Zhang X, Jankovic J. Genetic analysis of parkin co-regulated gene (PACRG) in patients with early-onset parkinsonism. Neurosci Lett. 2005;382:297-9.

Deng H, Le WD, Zhang X, Pan TH, Jankovic J. G309D and W437OPA PINK1 mutations in Caucasian Parkinson's disease patients. Acta Neurol Scand. 2005;111:351-2.

Grider MH, Mamounas LA, Le W, Shine HD. In situ expression of brain-derived neurotrophic factor or neurotrophin-3 promotes sprouting of cortical serotonergic axons following a neurotoxic lesion. J Neurosci Res. 2005;82:404-12.

Imam SZ, Jankovic J, Ali SF, Skinner JT, Xie W, Conneely OM, Le WD. Nitric oxide mediates increased susceptibility to dopaminergic damage in Nurr1 heterozygous mice. Faseb J. 2005;19:1441-50.

Jankovic J, Chen S, Le WD. The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Prog Neurobiol. 2005;77:128-38.

Jiang C, Wan X, He Y, Pan T, Jankovic J, Le W. Age-dependent dopaminergic dysfunction in Nurr1 knockout mice. Exp Neurol. 2005;191:154-62.

Pan T, Li X, Xie W, Jankovic J, Le W. Valproic acid-mediated Hsp70 induction and anti-apoptotic neuroprotection in SH-SY5Y cells. FEBS Lett. 2005;579:6716-20.

Pan T, Xie W, Jankovic J, Le W. Biological effects of pramipexole on dopaminergic neuron-associated genes: relevance to neuroprotection. Neurosci Lett. 2005;377:106-9.

Yang JH, Le WD, Basinger SF, Wu SM, Yang CY. Mechanisms of apoptosis in human retinal pigment epithelium induced by TNF-alpha in conditions of heavy metal ion deficiency. Invest Ophthalmol Vis Sci. 2005;46:1039-46.

Zhang X, Xie W, Qu S, Pan T, Wang X, Le W. Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration. Biochem Biophys Res Commun. 2005;333:544-9.

Deng H, Le W, Jankovic J. Premutation alleles associated with Parkinson disease and essential tremor. Jama. 2004;292:1685-6.

Jiang C, Wan X, Jankovic J, Christian ST, Pristupa ZB, Niznik HB, Sundsmo JS, Le W. Dopaminergic properties and experimental anti-parkinsonian effects of IPX750 in rodent models of Parkinson disease. Clin Neuropharmacol. 2004;27:63-73.

Le W, Appel SH. Mutant genes responsible for Parkinson's disease. Curr Opin Pharmacol. 2004;4:79-84.

Pan T, Le W, Jankovic J. Slowing Parkinson's disease progression: recent dopamine agonist trials. Neurology. 2004;62:343; author reply 343-4.

Rachakonda V, Pan TH, Le WD. Biomarkers of neurodegenerative disorders: how good are they? Cell Res. 2004;14:347-58.

Thomas M, Le WD. Minocycline: neuroprotective mechanisms in Parkinson's disease. Curr Pharm Des. 2004;10:679-86.

Zhao W, Xie W, Le W, Beers DR, He Y, Henkel JS, Simpson EP, Yen AA, Xiao Q, Appel SH. Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism. J Neuropathol Exp Neurol. 2004;63:964-77.

He Y, Imam SZ, Dong Z, Jankovic J, Ali SF, Appel SH, Le W. Role of nitric oxide in rotenone-induced nigro-striatal injury. J Neurochem. 2003;86:1338-45.

Le WD, Xu P, Jankovic J, Jiang H, Appel SH, Smith RG, Vassilatis DK. Mutations in NR4A2 associated with familial Parkinson disease. Nat Genet. 2003;33:85-9.

Pan T, Fei J, Zhou X, Jankovic J, Le W. Effects of green tea polyphenols on dopamine uptake and on MPP+ -induced dopamine neuron injury. Life Sci. 2003;72:1073-83.

Pan T, Jankovic J, Le W. Potential therapeutic properties of green tea polyphenols in Parkinson's disease. Drugs Aging. 2003;20:711-21.

Thomas M, Le WD, Jankovic J. Minocycline and other tetracycline derivatives: a neuroprotective strategy in Parkinson's disease and Huntington's disease. Clin Neuropharmacol. 2003;26:18-23.

He Y, Le WD, Appel SH. Role of Fcgamma receptors in nigral cell injury induced by Parkinson disease immunoglobulin injection into mouse substantia nigra. Exp Neurol. 2002;176:322-7.

Mohamed HA, Mosier DR, Zou LL, Siklos L, Alexianu ME, Engelhardt JI, Beers DR, Le WD, Appel SH. Immunoglobulin Fc gamma receptor promotes immunoglobulin uptake, immunoglobulin-mediated calcium increase, and neurotransmitter release in motor neurons. J Neurosci Res. 2002;69:110-6.

Xu PY, Liang R, Jankovic J, Hunter C, Zeng YX, Ashizawa T, Lai D, Le WD. Association of homozygous 7048G7049 variant in the intron six of Nurr1 gene with Parkinson's disease. Neurology. 2002;58:881-4.

He Y, Appel S, Le W. Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum. Brain Res. 2001;909:187-93.

Le W, Rowe D, Xie W, Ortiz I, He Y, Appel SH. Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease. J Neurosci. 2001;21:8447-55.

Le WD, Jankovic J. Are dopamine receptor agonists neuroprotective in Parkinson's disease? Drugs Aging. 2001;18:389-96.

Xu P, Liang X, Jankovic J, Le W. Identification of a high frequency of mutation at exon 8 of the ATP7B gene in a Chinese population with Wilson disease by fluorescent PCR. Arch Neurol. 2001;58:1879-82.

Engelhardt JI, Le WD, Siklos L, Obal I, Boda K, Appel SH. Stereotaxic injection of IgG from patients with Alzheimer disease initiates injury of cholinergic neurons of the basal forebrain. Arch Neurol. 2000;57:681-6.

Le WD, Jankovic J, Xie W, Appel SH. Antioxidant property of pramipexole independent of dopamine receptor activation in neuroprotection. J Neural Transm. 2000;107:1165-73.

Ondo WG, He Y, Rajasekaran S, Le WD. Clinical correlates of 6-hydroxydopamine injections into A11 dopaminergic neurons in rats: a possible model for restless legs syndrome. Mov Disord. 2000;15:154-8.

Zou L, Xu J, Jankovic J, He Y, Appel SH, Le W. Pramipexole inhibits lipid peroxidation and reduces injury in the substantia nigra induced by the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice. Neurosci Lett. 2000;281:167-70.

Le W, Conneely OM, He Y, Jankovic J, Appel SH. Reduced Nurr1 expression increases the vulnerability of mesencephalic dopamine neurons to MPTP-induced injury. J Neurochem. 1999;73:2218-21.

Le W, Conneely OM, Zou L, He Y, Saucedo-Cardenas O, Jankovic J, Mosier DR, Appel SH. Selective agenesis of mesencephalic dopaminergic neurons in Nurr1-deficient mice. Exp Neurol. 1999;159:451-8.

Le WD, Rowe DB, Jankovic J, Xie W, Appel SH. Effects of cerebrospinal fluid from patients with Parkinson disease on dopaminergic cells. Arch Neurol. 1999;56:194-200.

Le WD, Xie WJ, Appel SH. Protective role of heme oxygenase-1 in oxidative stress-induced neuronal injury. J Neurosci Res. 1999;56:652-8.

Zou L, Jankovic J, Rowe DB, Xie W, Appel SH, Le W. Neuroprotection by pramipexole against dopamine- and levodopa-induced cytotoxicity. Life Sci. 1999;64:1275-85.

Chen S, Le WD, Xie WJ, Alexianu ME, Engelhardt JI, Siklos L, Appel SH. Experimental destruction of substantia nigra initiated by Parkinson disease immunoglobulins. Arch Neurol. 1998;55:1075-80.

Rowe DB, Le W, Smith RG, Appel SH. Antibodies from patients with Parkinson's disease react with protein modified by dopamine oxidation. J Neurosci Res. 1998;53:551-8.

Kalman J, Engelhardt JI, Le WD, Xie W, Kovacs I, Kasa P, Appel SH. Experimental immune-mediated damage of septal cholinergic neurons. J Neuroimmunol. 1997;77:63-74.

Le W, Jankovic J, Xie W, Kong R, Appel SH. (-)-Deprenyl protection of 1-methyl-4 phenylpyridium ion (MPP+)-induced apoptosis independent of MAO-B inhibition. Neurosci Lett. 1997;224:197-200.

Le WD, Xie WJ, Kong R, Appel SH. Beta-amyloid-induced neurotoxicity of a hybrid septal cell line associated with increased tau phosphorylation and expression of beta-amyloid precursor protein. J Neurochem. 1997;69:978-85.

Appel SH, Smith RG, Le WD. Immune-mediated cell death in neurodegenerative disease. Adv Neurol. 1996;69:153-9.

Le W, Yang K, Whitson JS, Clifton GL, Hayes RL. Liposome-mediated NGF gene transfection increases ChAT activity in CNS cell cultures. Neuroreport. 1996;7:710-2.

Le W, Xie WJ, Nyormoi O, Ho BK, Smith RG, Appel SH. beta-Amyloid1-40 increases expression of beta-amyloid precursor protein in neuronal hybrid cells. J Neurochem. 1995;65:2373-6.

Le WD, Colom LV, Xie WJ, Smith RG, Alexianu M, Appel SH. Cell death induced by beta-amyloid 1-40 in MES 23.5 hybrid clone: the role of nitric oxide and NMDA-gated channel activation leading to apoptosis. Brain Res. 1995;686:49-60.

Le WD, Engelhardt J, Xie WJ, Schneider L, Smith RG, Appel SH. Experimental autoimmune nigral damage in guinea pigs. J Neuroimmunol. 1995;57:45-53.

Le WD, Xie WJ, Smith RG, Appel SH. Vimentin-crossreactive antibodies induce cell death in primary cultures of embryonic spinal cord. J Neuroimmunol. 1993;42:15-22.

Appel SH, Le WD, Tajti J, Haverkamp LJ, Engelhardt JI. Nigral damage and dopaminergic hypofunction in mesencephalon-immunized guinea pigs. Ann Neurol. 1992;32:494-501.

Crawford GD, Jr., Le WD, Smith RG, Xie WJ, Stefani E, Appel SH. A novel N18TG2 x mesencephalon cell hybrid expresses properties that suggest a dopaminergic cell line of substantia nigra origin. J Neurosci. 1992;12:3392-8.

Le WD, Bostwick JR, Appel SH. Use of [3H]-GBR12935 to measure dopaminergic nerve terminal growth into the developing rat striatum. Brain Res Dev Brain Res. 1992;67:375-7.

Rabinovsky ED, Le WD, McManaman JL. Differential effects of neurotrophic factors on neurotransmitter development in the IMR-32 human neuroblastoma cell line. J Neurosci. 1992;12:171-9.

Bostwick JR, Le WD. A tyrosine hydroxylase assay in microwells using coupled nonenzymatic decarboxylation of dopa. Anal Biochem. 1991;192:125-30.

Book Chapters and Other Publications
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Ondo WG, Zhao HR, Le WD. Animal models of restless legs syndrome. In: Chokroverty S, McCarley R, editors. Clinical neuroscience research: advances in sleep medicine. 2008. (in press).

Poster and Platform Presentations
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Le W, Nguyen D, Lin W, Rawal P, Ding Y, Xie W, Deng H, Jankovic J. Transcription factor PITX3 in Parkinson's disease. Mov Disord. 2009;24 Suppl 1:S143.

Li C, Biswas S, Xie WJ, Dutta AK, Le WD. Novel multifunctional drug D-264 for Parkinson's disease: Evidence of neuroprotective property in PD animal models induced by MPTP and lactacystin. American Neurological Association (ANA), 134th Annual Meeting in Baltimore, Maryland (Oct. 11-14, 2009).

Pan T, Xie W, Jankovic J, Le W. 17-AAG protects against rotenone-induced apoptosis in SHSY5Y cells via HSP70 induction. Mov Disord. 2009;24 Suppl 1:S361.

Pan T, Xie W, Le W, Jankovic J. Resveratrol, a polyphenol found in red wine, protects against rotenone-induced apoptosis through autophagy induction. Mov Disord. 2009;24 Suppl 1:S225-6.

Pan T, Xie W, Rawal P, Jankovic J, Le W. Rapamycin protects against rotenone-induced apoptosis through autophagy induction in SH-SY5Y cells. Neurology. 2009;72(11 Suppl 3):A438-9.

Le WD, Pan T, Xie W, Huang M, Xu P, Zhu W, Zhang X, Deng H, Jankovic J. Expanded study of NURR1 gene expression in patients with Parkinson's disease. Mov Disord. 2008;23 Suppl 1:S36.

Lou FF, Zhu W, Xie W, Ondo W, Le W. Short-term and long-term improvement by pramipexole in restless leg syndrome animal model. Ann Neurol. 2008;64 Suppl 12:S54.

Pan T, Li X, Xie W, Jankovic J, Le WD. Role of deferoxamine and autophagy induction in rotenone-induced apoptosis. Neurology. 2008;70(11 Suppl 1):A325-7.

Pan T, Xie W, Jankovic J, Le WD. Rapamycin rescues lactacystin-induced dopaminergic neuron injury in vivo. Mov Disord. 2008;23 Suppl 1:S23.

Walters AS, Ondo W, Zhu W, Le WD. Thalamic endogenous opioids are decreased in restless legs syndrome: A post-mortem study. Ann Neurol. 2008;64 Suppl 12:S29-30.

Xie W, Zhu W, Pan T, Jankovic J, Le W. Progressive DA neuron degeneration induced by targeting administration of proteasome inhibitor in SN. Ann Neurol. 2008;64 Suppl 12:S46-7.

Deng H, Le W, Shahed J, Jankovic J. Three parkin mutations in a family with Parkinson's disease. Neurology. 2007;68(12 Suppl 1):A323.

Pan T, Li X, Zhu W, Xie W, Jankovic J, Le W. Autophagy induction and its neuroprotection on neurotoxin-induced cell injury relevant to Parkinson's disease. Neurology. 2007;68(12 Suppl 1):A111.

Zhu W, Pan T, Xie W, Jankovic J, Zheng H, Youdim M, Le W. Brain permeable iron chelators M-30 and AK-28 rescue degenerated nigral dopamine neurons in animal model of PD. Mov Disord. 2007:22 Suppl 16:S201.

Zhu W, Pan T, Xie W, Xu P, Jankovic J, Youdim MBH, Le W. Comparison of neuroprotective and neurorescue capabilities of rasagiline and selegiline, against lactacystin induced nigrostriatal degeneration. Neurodegener Dis. 2007;4 Suppl 1:90.

Zhu W, Pan T, Xie W, Xu P, Zheng H, Fridkin M, Jankovic J, Youdim MBH, Le W. Novel brain permeable iron chelators prevent lactacystin induced ubiquitn-proteasome inhibition and degeneration of nigrostrialtal dopamine neurons. Neurology. 2007;68(12 Suppl 1):A113.

Zhu W, Pan T, Zhang X, Xie W, Jankovic J, Le W. Proteasome inhibition in substantial nigra induces sustained dopamine cells degeneration. Neurology. 2007;68(12 Suppl 1):A111.

Deng H, Le W, Davidson AL, Xie W, Jankovic J. Examination of LRRK2 I2012T, G2019S, and I2020T mutations in patients with essential tremor. Mov Disord. 2006;21 Suppl 15:S704.

Deng H, Le W, Guo Y, Hunter CB, Xie W, Huang M, Jankovic J. Examination of LRRK2 I2012T, G2019S, and I2020T mutations in patients with essential tremor. Ann Neurol. 2006;60 Suppl 10:S74.

Deng H, Le W, Hunter CB, Xie W, Mejia N, Jankovic J. A Mexican pedigree with Parkinson's disease, essential tremor and bell's palsy associated with parkin but not HS1BP3 gene mutation. Ann Neurol. 2006;60 Suppl 10:S58.

Deng H, Le W, Xie W, Jankovic J. Genetic analysis of the SLITRK1 gene in caucasian patients with Tourette syndrome. Ann Neurol. 2006;60 Suppl 10:S74.

Pan T, Kondo S, Zhu W, Xie W, Jankovic J, Le W. Enhancement of autophagy and neuroprotection by rapamycin in lactacystin-induced injury of dopaminergic neurons. Mov Disord. 2006;21 Suppl 15:S505.

Zhao H, Zhu W, Pan T, Xie W, Ondo W, Le W. Spinal cord dopamine receptor expression and function in mice with 6-OHDA lesion of the A11 nucleus and dietary iron deprivation. Mov Disord. 2006;21 Suppl 15:S341.

Deng H, Jankovic J, Pan T, Xie W, Le W. Small interfering RNA (SiRNA) targeting the PINK1 induces apoptosisin human SH-SY5Y cells. Mov Disord. 2005:20 Suppl 10:S127.

Deng H, Jankovic J, Xie W, Pan T, Le W. Reduced NURR1 gene expression affects expression of dopaminergic phenotypic markers and Parkinson's disease-related genes. Mov Disord. 2005:20 Suppl 10:S143.

Deng H, Le W, Zhang X, Pan T, Jankovic J. Genetic analysis of G309D and W4370PA mutations of PINK1 in Parkinson's disease. Neurology. 2005;64(6 Suppl 1):A90.

Pan T, Xie W, Jankovic J, Le W. HSP70 inducer VPA inhibits rotenone-induced apoptosis in SH-SY5Y cells. Neurology. 2005;64(6 Suppl 1):A199.

Jiang C, Pan T, Jankovic J, Le W. Effects of ropinirole on progression of parkinsonism in Nurr1-deficient mice and its underlying mechanisms. Neurology. 2004:62(7 Suppl S5):A7.

Jiang C, Wan X, Jankovic J, Christian S, Sundsmo J, Le W. Dopaminergic properties and anti-parkinsonian effects of IPX750 in rodent models of Parkinson's disease. Neurology. 2004:62(7 Suppl S5):A9.

Le W, Jiang Q, Xie W, Hintermann S, Jankovic J. Nurr1 gene targeting therapy for Parkinson disease. Mov Disord. 2004:19 Suppl 9:S132.

Pan T, Jankovic J, Le W. The pharmacological and biological effects of pramipexole on dopamine transporter. Neurology. 2004:62(7 Suppl S5):A109.

Pan T, Xie W, Jankovic J, Le W. The pharmacological and biological effects of pramipexole on dopamine neuron associated genes: DAT, VMAT-2, and Nurr1. Mov Disord. 2004:19 Suppl 9:S215.

Pan T, Xie W, Jankovic J, Le W. Decreased Nurr1 mRNA in peripheral blood lymphocytes in Parkinson's disease. Neurology. 2004:62(7 Suppl S5):A108.

Le W, Imam SZ, Xie W, Ali S, Jankovic J. Reduced Nurr1 expression increases the susceptibility to dopaminergic toxins via nitric oxide. Mov Disord. 2002:17 Suppl 5:S27.

Pan TH, Xu PY, Xie WJ, Hunter C, Jankovic J, Le WD. Upregulation of Nurr1 gene expression by dopamine receptor agonist pramipexole in human neuroblastoma SHSY-5Y cells. Mov Disord. 2002:17 Suppl 5:S84.

Contact Information

Weidong Le, M.D., Ph.D.
Department of Neurology
Baylor College of Medicine
One Baylor Plaza, MS NB302
Houston, Texas 77030

Tel: 713-798-5142
Fax: 713-798-8307
Email: