Dennis M. Landis, M.D.

Professor of Neurology

Clinical Service Area

Neurology

Board Certification

American Board of Psychiatry and Neurology, Neurology
American Board of Psychiatry and Neurology, Vascular Neurology
American Board of Internal Medicine

Clinic Appointments

713-798-5975

Medical School

Harvard Medical School, Boston, MA

Internship

Internal Medicine, University of California - San Diego, LaJolla, CA

Residency

Internal Medicine, Brigham and Women's Hospital, Boston, MA
Neurology, Massachusetts General Hospital, Boston, MA

Clinic Location

Baylor Neurology
Smith Tower
6550 Fannin St., Suite 1801
Houston, TX 77030

Research Interests

Thrombolytic therapy for acute ischemic stroke

Publications

Pandya DJ, Gilkeson RC, Suarez JI, Tarr R, Schluchter M, Landis DM, Zaidat OO. Interobserver and intraobserver reliabilities of multislice electrocardiogram-gated spiral computerized tomography in evaluating aortic atheroma in patients with acute ischemic stroke. Clin Imaging 2008;32:109-13.
Zaidat OO, Slivka AP, Mohammad Y, Graffagnino C, Smith TP, Enterline DS, Christoforidis GA, Alexander MJ, Landis DM, Suarez JI. Intra-arterial thrombolytic therapy in peri-coronary angiography ischemic stroke. Stroke 2005;36:1089-90.
Zaidat OO, Suarez JI, Hedrick D, Redline S, Schluchter M, Landis DM, Hoit B. Reproducibility of transesophageal echocardiography in evaluating aortic atheroma in stroke patients. Echocardiography 2005;22:326-30.
Zaidat OO, Suarez JI, Sunshine JL, Tarr RW, Alexander MJ, Smith TP, Enterline DS, Selman WR, Landis DM. Thrombolytic therapy of acute ischemic stroke: correlation of angiographic recanalization with clinical outcome. AJNR Am J Neuroradiol 2005;26:880-4.
Leigh R, Zaidat OO, Suri MF, Lynch G, Sundararajan S, Sunshine JL, Tarr R, Selman W, Landis DM, Suarez JI. Predictors of hyperacute clinical worsening in ischemic stroke patients receiving thrombolytic therapy. Stroke 2004;35:1903-7.
Zaidat OO, Zahuranec DB, Ubogu EE, Fernandes-Filho JA, Suarez JI, Sunshine JL, Tarr RW, Mirarchi S, Nour SG, Selman WR, Landis DM. Asymptomatic middle cerebral artery stenosis diagnosed by magnetic resonance angiography. Neuroradiology 2004;46:49-53.
Katzan IL, Graber TM, Furlan AJ, Sundararajan S, Sila CA, Houser G, Landis DM. Cuyahoga County Operation Stroke speed of emergency department evaluation and compliance with National Institutes of Neurological Disorders and Stroke time targets. Stroke 2003;34:994-8.
Suarez JI, Zaidat OO, Sunshine JL, Tarr R, Selman WR, Landis DM. Endovascular administration after intravenous infusion of thrombolytic agents for the treatment of patients with acute ischemic strokes. Neurosurgery 2002;50:251-9; discussion 259-60.
Zaidat OO, Suarez JI, Santillan C, Sunshine JL, Tarr RW, Paras VH, Selman WR, Landis DM. Response to intra-arterial and combined intravenous and intra-arterial thrombolytic therapy in patients with distal internal carotid artery occlusion. Stroke 2002;33:1821-6.
Landis DM, Heindel CC, Loeb LA. Creation and characterization of 5-fluorodeoxyuridine-resistant Arg50 loop mutants of human thymidylate synthase. Cancer Res 2001;61:666-72.
Sunshine JL, Bambakidis N, Tarr RW, Lanzieri CF, Zaidat OO, Suarez JI, Landis DM, Selman WR. Benefits of perfusion MR imaging relative to diffusion MR imaging in the diagnosis and treatment of hyperacute stroke. AJNR Am J Neuroradiol 2001;22:915-21.
Landis DM. Current patterns and future possibilities in the care of acute ischemic stroke. Clin Neurosurg 1999;45:135-9.
Suarez JI, Sunshine JL, Tarr R, Zaidat O, Selman WR, Kernich C, Landis DM. Predictors of clinical improvement, angiographic recanalization, and intracranial hemorrhage after intra-arterial thrombolysis for acute ischemic stroke. Stroke 1999;30:2094-100.
Sunshine JL, Tarr RW, Lanzieri CF, Landis DM, Selman WR, Lewin JS. Hyperacute stroke: ultrafast MR imaging to triage patients prior to therapy. Radiology 1999;212:325-32.
Zaidat OO, Werz MA, Landis DM, Selman W. Orthostatic limb shaking from carotid hypoperfusion. Neurology 1999;53:650-1.
Landis DM, Tarr RW, Selman WR. Thrombolysis for acute ischemic stroke. Neurosurg Clin N Am 1997;8:219-26.
Rottach KG, von Maydell RD, Das VE, Zivotofsky AZ, Discenna AO, Gordon JL, Landis DM, Leigh RJ. Evidence for independent feedback control of horizontal and vertical saccades from Niemann-Pick type C disease. Vision Res 1997;37:3627-38.
Selman WR, Tarr R, Landis DM. Brain attack: emergency treatment of ischemic stroke. Am Fam Physician 1997;55:2655-62, 2665-6.
Landis DM. The early reactions of non-neuronal cells to brain injury. Annu Rev Neurosci 1994;17:133-51.
Pozzo Miller LD, Mahanty NK, Connor JA, Landis DM. Spontaneous pyramidal cell death in organotypic slice cultures from rat hippocampus is prevented by glutamate receptor antagonists. Neuroscience 1994;63:471-87.
Pozzo Miller LD, Landis DM. Cytoplasmic structure in organotypic cultures of rat hippocampus prepared by rapid freezing and freeze-substitution fixation. Synapse 1993;13:195-205.
Landis DM, Weinstein LA, Skordeles CJ. Effects of dexamethasone on the differentiation of membrane structure in cultured astrocytes. Glia 1991;4:335-44.
Landis DM, Welter E, Skordeles C. A novel epitope expressed on the surface of developing and mature astrocytes. Neuroscience 1991;45:467-77.
Landis DM, Weinstein LA, Skordeles CJ. Serum influences the differentiation of membrane structure in cultured astrocytes. Glia 1990;3:212-21.
Landis DM, Payne HR, Weinstein LA. Changes in the structure of synaptic junctions during climbing fiber synaptogenesis. Synapse 1989;4:281-93.
Landis DM, Reese TS. Substructure in the assemblies of intramembrane particles in astrocytic membranes. J Neurocytol 1989;18:819-31.
Andrews SB, Leapman RD, Landis DM, Reese TS. Activity-dependent accumulation of calcium in Purkinje cell dendritic spines. Proc Natl Acad Sci U S A 1988;85:1682-5.
Landis DM. Membrane and cytoplasmic structure at synaptic junctions in the mammalian central nervous system. J Electron Microsc Tech 1988;10:129-51.
Landis DM, Hall AK, Weinstein LA, Reese TS. The organization of cytoplasm at the presynaptic active zone of a central nervous system synapse. Neuron 1988;1:201-9.
Andrews SB, Leapman RD, Landis DM, Reese TS. Distribution of calcium and potassium in presynaptic nerve terminals from cerebellar cortex. Proc Natl Acad Sci U S A 1987;84:1713-7.
Landis DM, Weinstein LA, Reese TS. Substructure in the postsynaptic density of Purkinje cell dendritic spines revealed by rapid freezing and etching. Synapse 1987;1:552-8.
Sagar SM, Marshall PE, Onesti ST, Landis DM. Somatostatin immunocytochemistry in the rabbit retina. Invest Ophthalmol Vis Sci 1986;27:316-22.
Beal MF, Marshall PE, Burd GD, Landis DM, Martin JB. Excitotoxin lesions do not mimic the alteration of somatostatin in Huntington's disease. Brain Res 1985;361:135-45.
Benson TE, Burd GD, Greer CA, Landis DM, Shepherd GM. High-resolution 2-deoxyglucose autoradiography in quick-frozen slabs of neonatal rat olfactory bulb. Brain Res 1985;339:67-78.
Harris KM, Marshall PE, Landis DM. Ultrastructural study of cholecystokinin-immunoreactive cells and processes in area CA1 of the rat hippocampus. J Comp Neurol 1985;233:147-58.
Marshall PE, Landis DM. Huntington's disease is accompanied by changes in the distribution of somatostatin-containing neuronal processes. Brain Res 1985;329:71-82.
Reese BF, Landis DM, Reese TS. Organization of the cerebellar cortex viewed by scanning electron microscopy. Neuroscience 1985;14:133-46.
Sagar SM, Marshall PE, Landis DM. Immunoreactive somatostatin in the rat retina: light microscopic immunocytochemistry and chromatographic characterization. Brain Res 1985;336:235-42.
Halperin JJ, Landis DM, Weinstein LA, Lott IT, Kolodny EH. Communicating hydrocephalus and lysosomal inclusions in mannosidosis. Arch Neurol 1984;41:777-9.
Sagar SM, Beal MF, Marshall PE, Landis DM, Martin JB. Implications of neuropeptides in neurological diseases. Peptides 1984;:255-62.
Weinstein LA, Landis DM, Sagar SM, Millard WJ, Martin JB. Cysteamine depletes prolactin (PRL) but does not alter the structure of PRL-containing granules in the anterior pituitary. Endocrinology 1984;115:1543-50.
Landis DM, Reese TS. Cytoplasmic organization in cerebellar dendritic spines. J Cell Biol 1983;97:1169-78.
Landis DM, Weinstein LA. Membrane structure in cultured astrocytes. Brain Res 1983;276:31-41.
Landis DM, Weinstein LA, Halperin JJ. Development of synaptic junctions in cerebellar glomeruli. Brain Res 1983;284:231-45.
Marshall PE, Landis DM, Zalneraitis EL. Immunocytochemical studies of substance P and leucine-enkephalin in Huntington's disease. Brain Res 1983;289:26-Nov.
Halperin JJ, Landis DM, Kleinman GM. Whipple disease of the nervous system. Neurology 1982;32:612-7.
Halperin JJ, Landis DM, Lott IT, Ment L. Neuroaxonal dystrophy and Down's syndrome. Report of a case. Arch Neurol 1982;39:587-91.
Landis DM, Reese TS. Regional organization of astrocytic membranes in cerebellar cortex. Neuroscience 1982;7:937-50.
Millard WJ, Sagar SM, Landis DM, Martin JB. Cysteamine: a potent and specific depletor of pituitary prolactin. Science 1982;217:452-4.
Sagar SM, Rorstad OP, Landis DM, Arnold MA, Martin JB. Somatostatin-like immunoreactive material in the rabbit retina. Brain Res 1982;244:91-9.
Landis DM, Reese TS. Membrane structure in mammalian astrocytes: a review of freeze-fracture studies on adult, developing, reactive and cultured astrocytes. J Exp Biol 1981;95:35-48.
Landis DM, Reese TS. Astrocyte membrane structure: changes after circulatory arrest. J Cell Biol 1981;88:660-3.
Landis DM, Williams RS, Masters CL. Golgi and electronmicroscopic studies of spongiform encephalopathy. Neurology 1981;31:538-49.
Gulley RL, Landis DM, Reese TS. Internal organization of membranes at end bulbs of Held in the anteroventral cochlear nucleus. J Comp Neurol 1978;180:707-41.
Landis DM, Landis SC. Several mutations in mice that affect the cerebellum. Adv Neurol 1978;21:85-105.
Landis DM, Sidman RL. Electron microscopic analysis of postnatal histogenesis in the cerebellar cortex of staggerer mutant mice. J Comp Neurol 1978;179:831-63.
Landis DM, Reese TS. Structure of the Purkinje cell membrane in staggerer and weaver mutant mice. J Comp Neurol 1977;171:247-60.
Henkart M, Landis DM, Reese TS. Similarity of junctions between plasma membranes and endoplasmic reticulum in muscle and neurons. J Cell Biol 1976;70:338-47.
Heuser JE, Reese TS, Landis DM. Preservation of synaptic structure by rapid freezing. Cold Spring Harb Symp Quant Biol 1976;40:17-24.
Nabeshima S, Reese TS, Landis DM, Brightman MW. Junctions in the meninges and marginal glia. J Comp Neurol 1975;164:127-69.
Heuser JE, Reese TS, Landis DM. Functional changes in frog neuromuscular junctions studied with freeze-fracture. J Neurocytol 1974;3:109-31.
Landis DM, Reese TS. Differences in membrane structure between excitatory and inhibitory synapses in the cerebellar cortex. J Comp Neurol 1974;155:93-125.
Landis DM, Reese TS. Arrays of particles in freeze-fractured astrocytic membranes. J Cell Biol 1974;60:316-20.
Landis DM, Reese TS, Raviola E. Differences in membrane structure between excitatory and inhibitory components of the reciprocal synapse in the olfactory bulb. J Comp Neurol 1974;155:67-91.
Landis DM, Rosenberg RN, Landis SC, Schut L, Nyhan WL. Olivopontocerebellar degeneration. Clinical and ultrastructural abnormalities. Arch Neurol 1974;31:295-307.

Invited Speaker and Participant in Courses, Workshops, Symposia and Conferences

Invited speaker: Management of Acute Ischemic Stroke. Texas Neurological Society, Houston, Texas. (July 17, 2007)
Invited speaker: Prevention and Emergency Treatment of Brain Attack. Parkinson Foundation of Harris County, West University Place, Texas. (April 20, 2007)
Invited speaker: Treatment and Prevention of Acute Ischemic Stroke. Neurosurgery Grand Rounds, Baylor College of Medicine, Houston, Texas. (April 13, 2007)
Invited speaker: Brain Attack. Thrombolysis in Acute Ischemic Stroke. Neurology Grand Rounds, St. Luke's Episcopal Hospital, Houston, Texas. (April 11, 2007)
Invited speaker: Causes of Ischemic Stroke. Center for Neurosciences First Annual Stroke Symposium, Cleveland, Ohio. (Sept. 30, 2005)
Invited speaker: Brain Attack and First Responders. EMS Regional Symposium, Lyndhurst, Ohio. (Sept. 21, 2005)
Invited speaker: Secondary Prevention of Ischemic Stroke. St. John Westshore Hospital, Westlake, Ohio. (Aug. 31, 2005)
Invited speaker: Physician Scientists in Neurology. National Association of M.D.-Ph.D. Programs, Keystone, Colo. (July 30, 2005)
Invited speaker: Treatment and Prevention of Stroke. Amici Medicinae, School of Medicine, Case Western Reserve University, Cleveland, Ohio. (May 9, 2005)
Invited speaker: Brain Attack and First Responders. University Hospitals of Cleveland, Cleveland, Ohio. (May 5, 2005)
Invited speaker: Prevention and Treatment of Stroke. Retired Executives Club, Highland Hts, Ohio. (Sept. 16, 2004)
Invited speaker: Brain Attack and First Responders. Richmond Heights Hospital, Cleveland, Ohio. (Jan. 8, 2004)

Contact Information

Dennis M. Landis, M.D.
Department of Neurology
Baylor College of Medicine
One Baylor Plaza, MS NB302
Houston, Texas 77030

Tel: 713-798-7990
Fax: 713-798-2739
Email: