Thomas A. Kent, M.D.

Professor of Neurology
Chief of Neurology,
Michael E. DeBakey Veterans Affairs Medical Center
Director of Stroke Research and Education

Medical School

M.D. (1979) University of Kansas Medical Center

Clinical Interests

Acute Stroke therapy, Diabetes and Stroke, Interface of psychiatry with neurological illness

Research Interests

Novel anti-thrombotic therapies for acute stroke, mechanisms of interaction between hyperglycemia and the cerebral vasculature, transcriptional events in stroke recovery, development of analytical methods for neuroimaging

Publications
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Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH. Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations. Stroke. 2009;:.
Kent TA, Rutherford DG, Breier JI, Papanicoloau AC. What is the evidence for use dependent learning after stroke? Stroke. 2009;40:S139-40.
Mandava P, Kent TA. A Method to Determine Stroke Trial Success Using Multidimensional Pooled Control Functions. Stroke. 2009;:.
Mandava P, Kent TA. Percutaneous clot removal in acute ischemic stroke. Arch Neurol. 2009;66:283-4; author reply 284.
Bruno A, Kent TA, Coull BM, Shankar RR, Saha C, Becker KJ, Kissela BM, Williams LS. Treatment of hyperglycemia in ischemic stroke (THIS): a randomized pilot trial. Stroke. 2008;39:384-9.
Dong JF, Cruz MA, Aboulfatova K, Martin C, Choi H, Bergeron AL, Martini SR, Kroll MH, Kent TA. Magnesium maintains endothelial integrity, up-regulates proteolysis of ultra-large von Willebrand factor, and reduces platelet aggregation under flow conditions. Thromb Haemost. 2008;99:586-93.
Fabian RH, Perez-Polo JR, Kent TA. Perivascular nitric oxide and superoxide in neonatal cerebral hypoxia-ischemia. Am J Physiol Heart Circ Physiol. 2008;295:H1809-14.
Mandava P, Suarez JI, Kent TA. Intravenous rt-PA versus Endovascular Therapy for Acute Ischemic Stroke. Curr Atheroscler Rep. 2008;10:332-8.
Mandava P, Thiagarajan P, Kent TA. Glycoprotein IIb/IIIa Antagonists in Acute Ischaemic Stroke: Current Status and Future Directions. Drugs. 2008;68:1019-28.
Miller LA, Collins RL, Kent TA. Language and the modulation of impulsive aggression. J Neuropsychiatry Clin Neurosci. 2008;20:261-73.
Suarez JI, Kent TA. The time is right to improve organization of stroke care. Neurology. 2008;70:1232-3.
Teten AL, Miller LA, Bailey SD, Dunn NJ, Kent TA. Empathic deficits and alexithymia in trauma-related impulsive aggression. Behav Sci Law. 2008;26:823-32.
Fabian RH, Perez-Polo JR, Kent TA. A decoy oligonucleotide inhibiting nuclear factor-kappaB binding to the IgGkappaB consensus site reduces cerebral injury and apoptosis in neonatal hypoxic-ischemic encephalopathy. J Neurosci Res. 2007;85:1420-6.
Kent TA, Mandava P. Recanalization rates can be misleading. Stroke. 2007;38:e103; author reply e104.
Mandava P, Kent TA. Intra-arterial therapies for acute ischemic stroke. Neurology. 2007;68:2132-9.
Martini SR, Kent TA. Hyperglycemia in acute ischemic stroke: a vascular perspective. J Cereb Blood Flow Metab. 2007;27:435-51.
Simard JM, Kent TA, Chen M, Tarasov KV, Gerzanich V. Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications. Lancet Neurol. 2007;6:258-68.
Mandava P, Anderson JA, Kent TA. MRI-guided, open trial of abciximab for ischemic stroke within a 3- to 24-hour window. Neurology. 2006;66:1132.
Martini SR, Hill MD, Alexandrov AV, Molina CA, Kent TA. Outcome in hyperglycemic stroke with ultrasound-augmented thrombolytic therapy. Neurology. 2006;67:700-2.
Mandava P, Kent TA. Reversal of dense signs predicts recovery in acute ischemic stroke. Stroke. 2005;36:2490-2.
Mandava P, Lick SD, Rahman MA, Langsjoen H, Reddy KV, Nelson J, Kent TA. Initial safety experience of abciximab and heparin for acute ischemic stroke. Cerebrovasc Dis. 2005;19:276-8.
Bruno A, Williams LS, Kent TA. How important is hyperglycemia during acute brain infarction? Neurologist. 2004;10:195-200.
Fabian RH, Perez-Polo JR, Kent TA. Extracellular superoxide concentration increases following cerebral hypoxia but does not affect cerebral blood flow. Int J Dev Neurosci. 2004;22:225-30.
Simard JM, Kent TA. Vascular smooth muscle proliferation as a target for therapeutic intervention. Stroke. 2003;34:e108; author reply e108.
Mandava P, Bebensee A, Rawlings RR, Kent TA. Basilar artery aneurysm thrombosis. Neurology. 2002;59:1287.
Rempe DA, Kent TA. Using bone marrow stromal cells for treatment of stroke. Neurology. 2002;59:486-7.
Kent TA, Soukup VM, Fabian RH. Heterogeneity affecting outcome from acute stroke therapy: making reperfusion worse. Stroke. 2001;32:2318-27.
Qiu J, Grafe MR, Schmura SM, Glasgow JN, Kent TA, Rassin DK, Perez-Polo JR. Differential NF-kappa B regulation of bcl-x gene expression in hippocampus and basal forebrain in response to hypoxia. J Neurosci Res. 2001;64:223-34.
Fabian RH, Perez-Polo JR, Kent TA. Electrochemical monitoring of superoxide anion production and cerebral blood flow: effect of interleukin-1 beta pretreatment in a model of focal ischemia and reperfusion. J Neurosci Res. 2000;60:795-803.
Barratt ES, Stanford MS, Dowdy L, Liebman MJ, Kent TA. Impulsive and premeditated aggression: a factor analysis of self-reported acts. Psychiatry Res. 1999;86:163-73.
Fabian RH, Kent TA. Superoxide anion production during reperfusion is reduced by an antineutrophil antibody after prolonged cerebral ischemia. Free Radic Biol Med. 1999;26:355-61.
Guidry J, Kent TA. New genetic hypothesis of schizophrenia. Med Hypotheses. 1999;52:69-75.
Hillman GR, Chang CW, Ying H, Yen J, Ketonen L, Kent TA. A fuzzy logic approach to identifying brain structures in MRI using expert anatomic knowledge. Comput Biomed Res. 1999;32:503-16.
Kent TA, Quast M, Taglialatela G, Rea C, Wei J, Tao Z, Perez-Polo JR. Effect of NGF treatment on outcome measures in a rat model of middle cerebral artery occlusion. J Neurosci Res. 1999;55:357-69.
Edwards M, Kent TA, Rea HC, Wei J, Quast M, Izumi T, Mitra S, Perez-Polo JR. APE/Ref-1 responses to ischemia in rat brain. Neuroreport. 1998;9:4015-8.
Fabian RH, Dewitt DS, Kent TA. The 21-aminosteroid U-74389G reduces cerebral superoxide anion concentration following fluid percussion injury of the brain. J Neurotrauma. 1998;15:433-40.
Stroemer RP, Kent TA, Hulsebosch CE. Enhanced neocortical neural sprouting, synaptogenesis, and behavioral recovery with D-amphetamine therapy after neocortical infarction in rats. Stroke. 1998;29:2381-93; discussion 2393-5.
Barratt ES, Stanford MS, Felthous AR, Kent TA. The effects of phenytoin on impulsive and premeditated aggression: a controlled study. J Clin Psychopharmacol. 1997;17:341-9.
Barratt ES, Stanford MS, Kent TA, Felthous A. Neuropsychological and cognitive psychophysiological substrates of impulsive aggression. Biol Psychiatry. 1997;41:1045-61.
Mottet I, Quast MJ, Dewitt DS, Hillman GR, Wei J, Uhrbrock DH, Perez-Polo JR, Kent TA. NG-nitro-L-arginine methyl ester modifies the input function measured by dynamic susceptibility contrast magnetic resonance imaging. J Cereb Blood Flow Metab. 1997;17:791-800.
Noyes R, Jr., Moroz G, Davidson JR, Liebowitz MR, Davidson A, Siegel J, Bell J, Cain JW, Curlik SM, Kent TA, Lydiard RB, Mallinger AG, Pollack MH, Rapaport M, Rasmussen SA, Hedges D, Schweizer E, Uhlenhuth EH. Moclobemide in social phobia: a controlled dose-response trial. J Clin Psychopharmacol. 1997;17:247-54.
Quast MJ, Wei J, Huang NC, Brunder DG, Sell SL, Gonzalez JM, Hillman GR, Kent TA. Perfusion deficit parallels exacerbation of cerebral ischemia/reperfusion injury in hyperglycemic rats. J Cereb Blood Flow Metab. 1997;17:553-9.
Gelman BB, Dholakia S, Casper K, Kent TA, Cloyd MW, Freeman D, Jr. Expansion of the cerebral ventricles and correlation with acquired immunodeficiency syndrome neuropathology in 232 patients. Arch Pathol Lab Med. 1996;120:866-71.
Berryhill P, Lilly MA, Levin HS, Hillman GR, Mendelsohn D, Brunder DG, Fletcher JM, Kufera J, Kent TA, Yeakley J, et al. Frontal lobe changes after severe diffuse closed head injury in children: a volumetric study of magnetic resonance imaging. Neurosurgery. 1995;37:392-9; discussion 399-400.
Fabian RH, DeWitt DS, Kent TA. In vivo detection of superoxide anion production by the brain using a cytochrome c electrode. J Cereb Blood Flow Metab. 1995;15:242-7.
Fisher S, Kent TA, Bryant SG. Postmarketing surveillance by patient self-monitoring: preliminary data for sertraline versus fluoxetine. J Clin Psychiatry. 1995;56:288-96.
Kischell ER, Kehtarnavaz N, Hillman GR, Levin H, Lilly M, Kent TA. Classification of brain compartments and head injury lesions by neural networks applied to MRI. Neuroradiology. 1995;37:535-41.
Stroemer RP, Kent TA, Hulsebosch CE. Neocortical neural sprouting, synaptogenesis, and behavioral recovery after neocortical infarction in rats. Stroke. 1995;26:2135-44.
Fisher S, Bryant SG, Kent TA, Davis JE. Patient drug attributions and postmarketing surveillance. Pharmacotherapy. 1994;14:202-9.
Kent TA, Messina JL, Weinstock RS, Stein JP. Synergistic induction of gene 33 expression by retinoic acid and insulin. Endocrinology. 1994;134:2237-44.
Ahlgren-Beckendorf JA, Maggio WW, Chen F, Kent TA. Neurofibromatosis 1 mRNA expression in blood vessels. Biochem Biophys Res Commun. 1993;197:1019-24.
Fisher S, Bryant SG, Kent TA. Postmarketing surveillance by patient self-monitoring: trazodone versus fluoxetine. J Clin Psychopharmacol. 1993;13:235-42.
Quast MJ, Huang NC, Hillman GR, Kent TA. The evolution of acute stroke recorded by multimodal magnetic resonance imaging. Magn Reson Imaging. 1993;11:465-71.
Stroemer RP, Kent TA, Hulsebosch CE. Acute increase in expression of growth associated protein GAP-43 following cortical ischemia in rat. Neurosci Lett. 1993;162:51-4.
Kent TA, Jazayeri A, Simard JM. Calcium channels and nifedipine inhibition of serotonin-induced [3H]thymidine incorporation in cultured cerebral smooth muscle cells. J Cereb Blood Flow Metab. 1992;12:139-46.
Stroemer RP, Kent TA, Hulsebosch CE. Increase in synaptophysin immunoreactivity following cortical infarction. Neurosci Lett. 1992;147:21-4.
Barratt ES, Kent TA, Bryant SG, Felthous AR. A controlled trial of phenytoin in impulsive aggression. J Clin Psychopharmacol. 1991;11:388-9.
Hillman GR, Kent TA, Kaye A, Brunder DG, Tagare H. Measurement of brain compartment volumes in MR using voxel composition calculations. J Comput Assist Tomogr. 1991;15:640-6.
Kent TA, Quast MJ, Kaplan BJ, Lifsey RS, Eisenberg HM. Assessment of a superparamagnetic iron oxide (AMI-25) as a brain contrast agent. Magn Reson Med. 1990;13:434-43.
Bradley RH, Kent TA, Eisenberg HM, Quast MJ, Ward GA, Campbell GA, Hillman G. Middle cerebral artery occlusion in rats studied by magnetic resonance imaging. Stroke. 1989;20:1032-6.
Brower RD, Dreyer CF, Kent TA. Neuroleptic malignant syndrome in a child treated with metoclopramide for chemotherapy-related nausea. J Child Neurol. 1989;4:230-2.
Brown CS, Kent TA, Bryant SG, Gevedon RM, Campbell JL, Felthous AR, Barratt ES, Rose RM. Blood platelet uptake of serotonin in episodic aggression. Psychiatry Res. 1989;27:5-12.
Jazayeri A, Meyer WJ, 3rd, Kent TA. 5-HT1B and 5-HT2 serotonin binding sites in cultured Wistar-Kyoto rat aortic smooth muscle cells. Eur J Pharmacol. 1989;169:183-7.
Kent TA, Quast MJ, Kaplan BJ, Najafi A, Amparo EG, Gevedon RM, Salinas F, Suttle AD, DiPette DJ, Eisenberg HM. Cerebral blood volume in a rat model of ischemia by MR imaging at 4.7 T. AJNR Am J Neuroradiol. 1989;10:335-8.
Kent TA, Brown CS, Bryant SG, Barratt ES, Felthous AR, Rose RM. Blood platelet uptake of serotonin in episodic aggression: correlation with red blood cell proton T1 and impulsivity. Psychopharmacol Bull. 1988;24:454-7.
Kent TA, Gunn WH, Goodwin DW, Jones MP, Marples BW, Penick EC. Individual differences in state-dependent retrieval effects of alcohol intoxication. J Stud Alcohol. 1986;47:241-3.
Kent TA, Preskorn SH, Glotzbach RK, Irwin GH. Amitriptyline normalizes tetrabenazine-induced changes in cerebral microcirculation. Biol Psychiatry. 1986;21:483-91.
Kent TA, Sheftel TG, Sutton TE, Morrison LT, Mader JT. Effect of hyperbaric oxygen on the blood: cerebrospinal fluid transfer of tobramycin. Aviat Space Environ Med. 1986;57:664-6.
Kent TA, Campbell JL, Pazdernik TL, Hunter R, Gunn WH, Goodwin DW. Blood platelet uptake of serotonin in men alcoholics. J Stud Alcohol. 1985;46:357-9.
Kent TA, Nagy G, Oke AF, Preskorn SH, Adams RN. Effect of CO2 on a brain extracellular space marker and evidence of its neuronal modulation. Brain Res. 1985;342:141-4.
Kent TA, Preskorn SH. A modified method for the simultaneous determination of regional single-transit brain extraction of diffusion-limited compounds and cerebral blood flow: utilization of non-invasive measurement of transit time. Brain Res. 1985;335:251-5.
Weller RA, Penick EC, Powell BJ, Othmer E, Rice AS, Kent TA. Agreement between two structured psychiatric diagnostic interviews: DIS and the PDI. Compr Psychiatry. 1985;26:157-63.
Hughes CW, Kent TA, Campbell J, Oke A, Croskell H, Preskorn SH. Cerebral blood flow and cerebrovascular permeability in an inescapable shock (learned helplessness) animal model of depression. Pharmacol Biochem Behav. 1984;21:891-4.
Preskorn SH, Kent TA, Glotzbach RK, Irwin GH, Solnick JV. Cerebromicrocirculatory defects in animal model of depression. Psychopharmacology (Berl). 1984;84:196-9.
Kent TA, Pazdernik TL, Gunn WH, Penick EC, Marples BW, Jones MP, Goodwin DW. Platelet uptake of serotonin in ethanol intoxication: a preliminary study. Biol Psychiatry. 1983;18:929-33.
Kent TA, Wilber RD. Reserpine withdrawal psychosis: the possible role of denervation supersensitivity of receptors. J Nerv Ment Dis. 1982;170:502-4.

Poster Presentations
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Fabian R, Kent T. Apocynin decreases consequences of nitric oxide synthase uncoupling in experimental neonatal hypoxia-ischemia. Neurology. 2009;72(11 Suppl 3):A400.

Contact Information

Thomas A. Kent, M.D.
Department of Neurology
Baylor College of Medicine
One Baylor Plaza, MS NB302
Houston, Texas 77030

Tel: 713-794-7393
Fax: 713-794-7786
Email: