Department of Neurology

Thomas A. Kent, M.D.

Professor of Neurology

Chief of Neurology,
Michael E. DeBakey Veterans Affairs Medical Center

Director of Stroke Research and Education

 

Medical School

M.D. (1979) University of Kansas Medical Center

Clinical Interests

Acute Stroke therapy, Diabetes and Stroke, Interface of psychiatry with neurological illness

Research Interests

Novel anti-thrombotic therapies for acute stroke, mechanisms of interaction between hyperglycemia and the cerebral vasculature, transcriptional events in stroke recovery, development of analytical methods for neuroimaging

Publications

• Bruno A, Kent TA, Coull BM, Shankar RR, Saha C, Becker KJ, Kissela BM, Williams LS. Treatment of hyperglycemia in ischemic stroke (THIS): a randomized pilot trial. Stroke 2008;39:384-9.
• Dong JF, Cruz MA, Aboulfatova K, Martin C, Choi H, Bergeron AL, Martini SR, Kroll MH, Kent TA. Magnesium maintains endothelial integrity, up-regulates proteolysis of ultra-large von Willebrand factor, and reduces platelet aggregation under flow conditions. Thromb Haemost 2008;99:586-93.
• Suarez JI, Kent TA. The time is right to improve organization of stroke care. Neurology 2008;70:1232-3.
• Fabian RH, Perez-Polo JR, Kent TA. A decoy oligonucleotide inhibiting nuclear factor-kappaB binding to the IgGkappaB consensus site reduces cerebral injury and apoptosis in neonatal hypoxic-ischemic encephalopathy. J Neurosci Res 2007;85:1420-6.
• Kent TA, Mandava P. Recanalization rates can be misleading. Stroke 2007;38:e103; author reply e104.
• Mandava P, Kent TA. Intra-arterial therapies for acute ischemic stroke. Neurology 2007;68:2132-9.
• Martini SR, Kent TA. Hyperglycemia in acute ischemic stroke: a vascular perspective. J Cereb Blood Flow Metab 2007;27:435-51.
• Simard JM, Kent TA, Chen M, Tarasov KV, Gerzanich V. Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications. Lancet Neurol 2007;6:258-68.
• Mandava P, Anderson JA, Kent TA. MRI-guided, open trial of abciximab for ischemic stroke within a 3- to 24-hour window. Neurology 2006;66:1132.
• Martini SR, Hill MD, Alexandrov AV, Molina CA, Kent TA. Outcome in hyperglycemic stroke with ultrasound-augmented thrombolytic therapy. Neurology 2006;67:700-2.
• Mandava P, Kent TA. Reversal of dense signs predicts recovery in acute ischemic stroke. Stroke 2005;36:2490-2.
• Mandava P, Lick SD, Rahman MA, Langsjoen H, Reddy KV, Nelson J, Kent TA. Initial safety experience of abciximab and heparin for acute ischemic stroke. Cerebrovasc Dis 2005;19:276-8.
• Bruno A, Williams LS, Kent TA. How important is hyperglycemia during acute brain infarction?. Neurologist 2004;10:195-200.
• Fabian RH, Perez-Polo JR, Kent TA. Extracellular superoxide concentration increases following cerebral hypoxia but does not affect cerebral blood flow. Int J Dev Neurosci 2004;22:225-30.
• Simard JM, Kent TA. Vascular smooth muscle proliferation as a target for therapeutic intervention. Stroke 2003;34:e108; author reply e108.
• Mandava P, Bebensee A, Rawlings RR, Kent TA. Basilar artery aneurysm thrombosis. Neurology 2002;59:1287.
• Rempe DA, Kent TA. Using bone marrow stromal cells for treatment of stroke. Neurology 2002;59:486-7.
• Kent TA, Soukup VM, Fabian RH. Heterogeneity affecting outcome from acute stroke therapy: making reperfusion worse. Stroke 2001;32:2318-27.
• Qiu J, Grafe MR, Schmura SM, Glasgow JN, Kent TA, Rassin DK, Perez-Polo JR. Differential NF-kappa B regulation of bcl-x gene expression in hippocampus and basal forebrain in response to hypoxia. J Neurosci Res 2001;64:223-34.
• Fabian RH, Perez-Polo JR, Kent TA. Electrochemical monitoring of superoxide anion production and cerebral blood flow: effect of interleukin-1 beta pretreatment in a model of focal ischemia and reperfusion. J Neurosci Res 2000;60:795-803.
• Barratt ES, Stanford MS, Dowdy L, Liebman MJ, Kent TA. Impulsive and premeditated aggression: a factor analysis of self-reported acts. Psychiatry Res 1999;86:163-73.
• Fabian RH, Kent TA. Superoxide anion production during reperfusion is reduced by an antineutrophil antibody after prolonged cerebral ischemia. Free Radic Biol Med 1999;26:355-61.
• Guidry J, Kent TA. New genetic hypothesis of schizophrenia. Med Hypotheses 1999;52:69-75.
• Hillman GR, Chang CW, Ying H, Yen J, Ketonen L, Kent TA. A fuzzy logic approach to identifying brain structures in MRI using expert anatomic knowledge. Comput Biomed Res 1999;32:503-16.
• Kent TA, Quast M, Taglialatela G, Rea C, Wei J, Tao Z, Perez-Polo JR. Effect of NGF treatment on outcome measures in a rat model of middle cerebral artery occlusion. J Neurosci Res 1999;55:357-69.
• Edwards M, Kent TA, Rea HC, Wei J, Quast M, Izumi T, Mitra S, Perez-Polo JR. APE/Ref-1 responses to ischemia in rat brain. Neuroreport 1998;9:4015-8.
• Fabian RH, Dewitt DS, Kent TA. The 21-aminosteroid U-74389G reduces cerebral superoxide anion concentration following fluid percussion injury of the brain. J Neurotrauma 1998;15:433-40.
• Stroemer RP, Kent TA, Hulsebosch CE. Enhanced neocortical neural sprouting, synaptogenesis, and behavioral recovery with D-amphetamine therapy after neocortical infarction in rats. Stroke 1998;29:2381-93; discussion 2393-5.
• Barratt ES, Stanford MS, Felthous AR, Kent TA. The effects of phenytoin on impulsive and premeditated aggression: a controlled study. J Clin Psychopharmacol 1997;17:341-9.
• Barratt ES, Stanford MS, Kent TA, Felthous A. Neuropsychological and cognitive psychophysiological substrates of impulsive aggression. Biol Psychiatry 1997;41:1045-61.
• Henry EC, Kent TA, Gasiewicz TA. DNA binding and transcriptional enhancement by purified TCDD.Ah receptor complex. Arch Biochem Biophys 1997;339:305-14.
• Mottet I, Quast MJ, Dewitt DS, Hillman GR, Wei J, Uhrbrock DH, Perez-Polo JR, Kent TA. NG-nitro-L-arginine methyl ester modifies the input function measured by dynamic susceptibility contrast magnetic resonance imaging. J Cereb Blood Flow Metab 1997;17:791-800.
• Noyes R, Jr., Moroz G, Davidson JR, Liebowitz MR, Davidson A, Siegel J, Bell J, Cain JW, Curlik SM, Kent TA, Lydiard RB, Mallinger AG, Pollack MH, Rapaport M, Rasmussen SA, Hedges D, Schweizer E, Uhlenhuth EH. Moclobemide in social phobia: a controlled dose-response trial. J Clin Psychopharmacol 1997;17:247-54.
• Quast MJ, Wei J, Huang NC, Brunder DG, Sell SL, Gonzalez JM, Hillman GR, Kent TA. Perfusion deficit parallels exacerbation of cerebral ischemia/reperfusion injury in hyperglycemic rats. J Cereb Blood Flow Metab 1997;17:553-9.
• Gelman BB, Dholakia S, Casper K, Kent TA, Cloyd MW, Freeman D, Jr.. Expansion of the cerebral ventricles and correlation with acquired immunodeficiency syndrome neuropathology in 232 patients. Arch Pathol Lab Med 1996;120:866-71.
• Berryhill P, Lilly MA, Levin HS, Hillman GR, Mendelsohn D, Brunder DG, Fletcher JM, Kufera J, Kent TA, Yeakley J, et al.. Frontal lobe changes after severe diffuse closed head injury in children: a volumetric study of magnetic resonance imaging. Neurosurgery 1995;37:392-9; discussion 399-400.
• Fabian RH, DeWitt DS, Kent TA. In vivo detection of superoxide anion production by the brain using a cytochrome c electrode. J Cereb Blood Flow Metab 1995;15:242-7.
• Fisher S, Kent TA, Bryant SG. Postmarketing surveillance by patient self-monitoring: preliminary data for sertraline versus fluoxetine. J Clin Psychiatry 1995;56:288-96.
• Kischell ER, Kehtarnavaz N, Hillman GR, Levin H, Lilly M, Kent TA. Classification of brain compartments and head injury lesions by neural networks applied to MRI. Neuroradiology 1995;37:535-41.
• Stroemer RP, Kent TA, Hulsebosch CE. Neocortical neural sprouting, synaptogenesis, and behavioral recovery after neocortical infarction in rats. Stroke 1995;26:2135-44.
• Fisher S, Bryant SG, Kent TA, Davis JE. Patient drug attributions and postmarketing surveillance. Pharmacotherapy 1994;14:202-9.
• Kent TA, Messina JL, Weinstock RS, Stein JP. Synergistic induction of gene 33 expression by retinoic acid and insulin. Endocrinology 1994;134:2237-44.
• Ahlgren-Beckendorf JA, Maggio WW, Chen F, Kent TA. Neurofibromatosis 1 mRNA expression in blood vessels. Biochem Biophys Res Commun 1993;197:1019-24.
• Fisher S, Bryant SG, Kent TA. Postmarketing surveillance by patient self-monitoring: trazodone versus fluoxetine. J Clin Psychopharmacol 1993;13:235-42.
• Quast MJ, Huang NC, Hillman GR, Kent TA. The evolution of acute stroke recorded by multimodal magnetic resonance imaging. Magn Reson Imaging 1993;11:465-71.
• Stroemer RP, Kent TA, Hulsebosch CE. Acute increase in expression of growth associated protein GAP-43 following cortical ischemia in rat. Neurosci Lett 1993;162:51-4.
• Kent TA, Jazayeri A, Simard JM. Calcium channels and nifedipine inhibition of serotonin-induced [3H]thymidine incorporation in cultured cerebral smooth muscle cells. J Cereb Blood Flow Metab 1992;12:139-46.
• Stroemer RP, Kent TA, Hulsebosch CE. Increase in synaptophysin immunoreactivity following cortical infarction. Neurosci Lett 1992;147:21-4.
• Barratt ES, Kent TA, Bryant SG, Felthous AR. A controlled trial of phenytoin in impulsive aggression. J Clin Psychopharmacol 1991;11:388-9.
• Hillman GR, Kent TA, Kaye A, Brunder DG, Tagare H. Measurement of brain compartment volumes in MR using voxel composition calculations. J Comput Assist Tomogr 1991;15:640-6.
• Kent TA, Quast MJ, Kaplan BJ, Lifsey RS, Eisenberg HM. Assessment of a superparamagnetic iron oxide (AMI-25) as a brain contrast agent. Magn Reson Med 1990;13:434-43.
• Bradley RH, Kent TA, Eisenberg HM, Quast MJ, Ward GA, Campbell GA, Hillman G. Middle cerebral artery occlusion in rats studied by magnetic resonance imaging. Stroke 1989;20:1032-6.
• Brower RD, Dreyer CF, Kent TA. Neuroleptic malignant syndrome in a child treated with metoclopramide for chemotherapy-related nausea. J Child Neurol 1989;4:230-2.
• Brown CS, Kent TA, Bryant SG, Gevedon RM, Campbell JL, Felthous AR, Barratt ES, Rose RM. Blood platelet uptake of serotonin in episodic aggression. Psychiatry Res 1989;27:12-May.
• Jazayeri A, Meyer WJ, 3rd, Kent TA. 5-HT1B and 5-HT2 serotonin binding sites in cultured Wistar-Kyoto rat aortic smooth muscle cells. Eur J Pharmacol 1989;169:183-7.
• Kent TA, Quast MJ, Kaplan BJ, Najafi A, Amparo EG, Gevedon RM, Salinas F, Suttle AD, DiPette DJ, Eisenberg HM. Cerebral blood volume in a rat model of ischemia by MR imaging at 4.7 T. AJNR Am J Neuroradiol 1989;10:335-8.
• Kent TA, Brown CS, Bryant SG, Barratt ES, Felthous AR, Rose RM. Blood platelet uptake of serotonin in episodic aggression: correlation with red blood cell proton T1 and impulsivity. Psychopharmacol Bull 1988;24:454-7.
• Day EP, Kent TA, Lindahl PA, Munck E, Orme-Johnson WH, Roder H, Roy A. SQUID measurement of metalloprotein magnetization. New methods applied to the nitrogenase proteins. Biophys J 1987;52:837-53.
• Kent TA, Gunn WH, Goodwin DW, Jones MP, Marples BW, Penick EC. Individual differences in state-dependent retrieval effects of alcohol intoxication. J Stud Alcohol 1986;47:241-3.
• Kent TA, Preskorn SH, Glotzbach RK, Irwin GH. Amitriptyline normalizes tetrabenazine-induced changes in cerebral microcirculation. Biol Psychiatry 1986;21:483-91.
• Kent TA, Sheftel TG, Sutton TE, Morrison LT, Mader JT. Effect of hyperbaric oxygen on the blood: cerebrospinal fluid transfer of tobramycin. Aviat Space Environ Med 1986;57:664-6.
• Kent TA, Campbell JL, Pazdernik TL, Hunter R, Gunn WH, Goodwin DW. Blood platelet uptake of serotonin in men alcoholics. J Stud Alcohol 1985;46:357-9.
• Kent TA, Emptage MH, Merkle H, Kennedy MC, Beinert H, Munck E. Mossbauer studies of aconitase. Substrate and inhibitor binding, reaction intermediates, and hyperfine interactions of reduced 3Fe and 4Fe clusters. J Biol Chem 1985;260:6871-81.
• Kent TA, Nagy G, Oke AF, Preskorn SH, Adams RN. Effect of CO2 on a brain extracellular space marker and evidence of its neuronal modulation. Brain Res 1985;342:141-4.
• Kent TA, Preskorn SH. A modified method for the simultaneous determination of regional single-transit brain extraction of diffusion-limited compounds and cerebral blood flow: utilization of non-invasive measurement of transit time. Brain Res 1985;335:251-5.
• Lindahl PA, Day EP, Kent TA, Orme-Johnson WH, Munck E. Mossbauer, EPR, and magnetization studies of the Azotobacter vinelandii Fe protein. Evidence for a [4Fe-4S]1+ cluster with spin S = 3/2. J Biol Chem 1985;260:11160-73.
• Weller RA, Penick EC, Powell BJ, Othmer E, Rice AS, Kent TA. Agreement between two structured psychiatric diagnostic interviews: DIS and the PDI. Compr Psychiatry 1985;26:157-63.
• Andersson KK, Kent TA, Lipscomb JD, Hooper AB, Munck E. Mossbauer, EPR, and optical studies of the P-460 center of hydroxylamine oxidoreductase from Nitrosomonas. A ferrous heme with an unusually large quadrupole splitting. J Biol Chem 1984;259:6833-40.
• Fee JA, Findling KL, Yoshida T, Hille R, Tarr GE, Hearshen DO, Dunham WR, Day EP, Kent TA, Munck E. Purification and characterization of the Rieske iron-sulfur protein from Thermus thermophilus. Evidence for a [2Fe-2S] cluster having non-cysteine ligands. J Biol Chem 1984;259:124-33.
• Hughes CW, Kent TA, Campbell J, Oke A, Croskell H, Preskorn SH. Cerebral blood flow and cerebrovascular permeability in an inescapable shock (learned helplessness) animal model of depression. Pharmacol Biochem Behav 1984;21:891-4.
• Huynh BH, Kent TA. Mossbauer studies of iron proteins. Adv Inorg Biochem 1984;6:163-223.
• Kennedy MC, Kent TA, Emptage M, Merkle H, Beinert H, Munck E. Evidence for the formation of a linear [3Fe-4S] cluster in partially unfolded aconitase. J Biol Chem 1984;259:14463-71.
• Preskorn SH, Kent TA, Glotzbach RK, Irwin GH, Solnick JV. Cerebromicrocirculatory defects in animal model of depression. Psychopharmacology (Berl) 1984;84:196-9.
• Whittaker JW, Lipscomb JD, Kent TA, Munck E. Brevibacterium fuscum protocatechuate 3,4-dioxygenase. Purification, crystallization, and characterization. J Biol Chem 1984;259:4466-75.
• Arciero DM, Lipscomb JD, Huynh BH, Kent TA, Munck E. EPR and Mossbauer studies of protocatechuate 4,5-dioxygenase. Characterization of a new Fe2+ environment. J Biol Chem 1983;258:14981-91.
• Burger RM, Kent TA, Horwitz SB, Munck E, Peisach J. Mossbauer study of iron bleomycin and its activation intermediates. J Biol Chem 1983;258:1559-64.
• Emptage MH, Kent TA, Kennedy MC, Beinert H, Munck E. Mossbauer and EPR studies of activated aconitase: development of a localized valence state at a subsite of the [4Fe-4S] cluster on binding of citrate. Proc Natl Acad Sci U S A 1983;80:4674-8.
• Hille R, Yoshida T, Tarr GE, Williams CH, Jr., Ludwig ML, Fee JA, Kent TA, Huynh BH, Munck E. Studies of the ferredoxin from Thermus thermophilus. J Biol Chem 1983;258:13008-13.
• Kent TA, Pazdernik TL, Gunn WH, Penick EC, Marples BW, Jones MP, Goodwin DW. Platelet uptake of serotonin in ethanol intoxication: a preliminary study. Biol Psychiatry 1983;18:929-33.
• Kent TA, Young LJ, Palmer G, Fee JA, Munck E. Mossbauer study of beef heart cytochrome oxidase. Comparative study of the bovine enzyme and cytochrome c1aa3 from Thermus thermophilus. J Biol Chem 1983;258:8543-6.
• Kent TA, Dreyer JL, Kennedy MC, Huynh BH, Emptage MH, Beinert H, Munck E. Mossbauer studies of beef heart aconitase: evidence for facile interconversions of iron-sulfur clusters. Proc Natl Acad Sci U S A 1982;79:1096-100.
• Kent TA, Munck E, Dunham WR, Filter WF, Findling KL, Yoshida T, Fee JA. Mossbauer study of a bacterial cytochrome oxidase: cytochrome c1aa3 from Thermus thermophilus. J Biol Chem 1982;257:12489-92.
• Kent TA, Wilber RD. Reserpine withdrawal psychosis: the possible role of denervation supersensitivity of receptors. J Nerv Ment Dis 1982;170:502-4.
• Lipscomb JD, Andersson KK, Munck E, Kent TA, Hooper AB. Resolution of multiple heme centers of hydroxylamine oxidoreductase from Nitrosomonas. 2. Mossbauer spectroscopy. Biochemistry 1982;21:3973-6.
• Moura JJ, Moura I, Kent TA, Lipscomb JD, Huynh BH, LeGall J, Xavier AV, Munck E. Interconversions of [3Fe-3S] and [4Fe-4S] clusters. Mossbauer and electron paramagnetic resonance studies of Desulfovibrio gigas ferredoxin II. J Biol Chem 1982;257:6259-67.
• Emptage MH, Kent TA, Huynh BH, Rawlings J, Orme-Johnson WH, Munck E. On the nature of the iron-sulfur centers in a ferredoxin from Azotobacter vinelandii. Mossbauer studies and cluster displacement experiments. J Biol Chem 1980;255:1793-6.
• Huynh BH, Moura JJ, Moura I, Kent TA, LeGall J, Xavier AV, Munck E. Evidence for a three-iron center in a ferredoxin from Desulfovibrio gigas. Mossbauer and EPR studies. J Biol Chem 1980;255:3242-4.
• Kent TA, Huynh BH, Munck E. Iron-sulfur proteins: spin-coupling model for three-iron clusters. Proc Natl Acad Sci U S A 1980;77:6574-6.
• Kent TA, Spartalian K, Lang G, Yonetani T, Reed CA, Collman JP. High magnetic field Mossbauer studies of deoxymyoglobin, deoxyhemoglobin, and synthetic analogues. Biochim Biophys Acta 1979;580:245-58.

Contact Information

Thomas A. Kent, M.D.
Department of Neurology
Baylor College of Medicine
One Baylor Plaza, MS NB302
Houston, Texas 77030

Tel: 713-794-7393
Fax: 713-794-7786
Email:

• Home
• Patients & Visitors
• Clinical Programs
  • Autonomic Function
  • EMG/NCV
  • Epilepsy
  • Medical Neuromuscular
  • Memory & Dementia
  • Multiple Sclerosis
  • Neurogenetics
  • Parkinson’s & Movement Disorders
  • Sleep
  • Vascular Neurology
• Research Programs
  • Neurobiology
  • Neuroimmunology
  • Parkinson’s & Movement Disorders
• Education
  • Overview
  • BCM
    Medical Students
  • National & International Students
  • Residency in
    Adult Neurology
  • Residency in
    Pediatric Neurology
  • Residency Training in Neurology
    Slide Show
  • Clinical & Research Fellowships
  • Application Process
  • Clinical Neuroscience
    Grand Rounds
  • Neurology Seminars
  • Case of the Month
• Faculty
  • Neurology
  • Pediatric Neurology
  • Adjunct/Voluntary
  • Publications
  • Poster Presentations
  • Activities
• Calendar
  • Seminars & Rounds
  • Administration*
  • On-Call Schedule*
  • Past News & Events
• About Us
  • Neurology Yearbook
  • Texas Medical Center
• Help Us
  In Our Mission
• Links & Resources
• Resources
  *(BCM login required)
• Contact Us
  • Contact Neurology
  • Baylor Secure Messaging
  • BIGFILE Upload
  • Maps & Directions
• Site Map