Department of Neurology

James D. Frost, Jr., M.D.

Professor of Neurology

 

Medical School

M.D. (1962) Baylor University College of Medicine

Clinical Interests

Clinical neurophysiology. electroencephalography, epilepsy, infantile spasms, sleep disorders.

Research Interests

Etiology, pathophysiology and treatment of infantile spasms; development of automated electrophysiological and video techniques for the detection and characterization of epileptic seizures; sleep disorders.

Publications

• Guggenheim MA, Frost JD, Jr., Hrachovy RA. Time interval from a brain insult to the onset of infantile spasms. Pediatr Neurol 2008;38:34-7.
• Lee CL, Frost JD, Jr., Swann JW, Hrachovy RA. A new animal model of infantile spasms with unprovoked persistent seizures. Epilepsia 2008;49:298-307.
• Lee CL, Frost JD, Jr., Swann JW, Hrachovy RA. A new animal model of infantile spasms with unprovoked persistent seizures. Epilepsia 2007;:.
• Hrachovy RA, Frost JD, Jr.. The EEG in selected generalized seizures. J Clin Neurophysiol 2006;23:312-32.
• Karayiannis NB, Mukherjee A, Glover JR, Ktonas PY, Frost JD, Jr., Hrachovy RA, Mizrahi EM. Detection of pseudosinusoidal epileptic seizure segments in the neonatal EEG by cascading a rule-based algorithm with a neural network. IEEE Trans Biomed Eng 2006;53:633-41.
• Karayiannis NB, Tao G, Frost JD, Jr., Wise MS, Hrachovy RA, Mizrahi EM. Automated detection of videotaped neonatal seizures based on motion segmentation methods. Clin Neurophysiol 2006;117:1585-94.
• Karayiannis NB, Xiong Y, Frost JD, Jr., Wise MS, Hrachovy RA, Mizrahi EM. Automated detection of videotaped neonatal seizures based on motion tracking methods. J Clin Neurophysiol 2006;23:521-31.
• Karayiannis NB, Xiong Y, Tao G, Frost JD, Jr., Wise MS, Hrachovy RA, Mizrahi EM. Automated detection of videotaped neonatal seizures of epileptic origin. Epilepsia 2006;47:966-80.
• Frost JD, Jr., Hrachovy RA. Pathogenesis of infantile spasms: a model based on developmental desynchronization. J Clin Neurophysiol 2005;22:25-36.
• Karayiannis NB, Sami A, Frost JD, Jr., Wise MS, Mizrahi EM. Automated extraction of temporal motor activity signals from video recordings of neonatal seizures based on adaptive block matching. IEEE Trans Biomed Eng 2005;52:676-86.
• Karayiannis NB, Tao G, Xiong Y, Sami A, Varughese B, Frost JD, Jr., Wise MS, Mizrahi EM. Computerized motion analysis of videotaped neonatal seizures of epileptic origin. Epilepsia 2005;46:901-17.
• Karayiannis NB, Varughese B, Tao G, Frost JD, Jr., Wise MS, Mizrahi EM. Quantifying motion in video recordings of neonatal seizures by regularized optical flow methods. IEEE Trans Image Process 2005;14:890-903.
• Karayiannis NB, Xiong Y, Frost JD, Jr., Wise MS, Mizrahi EM. Quantifying motion in video recordings of neonatal seizures by robust motion trackers based on block motion models. IEEE Trans Biomed Eng 2005;52:1065-77.
• Karayiannis NB, Xiong Y, Frost JD, Jr., Wise MS, Mizrahi EM. Improving the accuracy and reliability of motion tracking methods used for extracting temporal motor activity signals from video recordings of neonatal seizures. IEEE Trans Biomed Eng 2005;52:747-9.
• Mitra J, Glover J, Ktonas P, Frost J, Hrachovy R, Mizrahi E. Rule-enhanced Clustering in the Detection of Neonatal Seizures. Conf Proc IEEE Eng Med Biol Soc 2005;1:948-51.
• Karayiannis NB, Mukherjee A, Glover JR, Ktonas PY, Frost JD, Jr., Hrachovy RA, Mizrahi EM. Quantifying and visualizing uncertainty in EEG data of neonatal seizures. Conf Proc IEEE Eng Med Biol Soc 2004;1:423-6.
• Karayiannis NB, Sami A, Frost JD, Jr., Wise MS, Mizrahi EM. Quantifying motion in video recordings of neonatal seizures by feature trackers based on predictive block matching. Conf Proc IEEE Eng Med Biol Soc 2004;2:1447-50.
• Karayiannis NB, Tao G, Varughese B, Frost JD, Jr., Wise MS, Mizrahi EM. Discrete optical flow estimation methods and their application in the extraction of motion strength signals from video recordings of neonatal seizures. Conf Proc IEEE Eng Med Biol Soc 2004;3:1718-21.
• Mitra J, Glover JR, Frost JD, Ktonas PA, Hrachovy RA, Mizrahi EM. Enhanced spatio-temporal clustering in the detection of neonatal seizures using context-based rules. Conf Proc IEEE Eng Med Biol Soc 2004;7:4717-20.
• Hrachovy RA, Frost JD, Jr.. Infantile epileptic encephalopathy with hypsarrhythmia (infantile spasms/West syndrome). J Clin Neurophysiol 2003;20:408-25.
• Karayiannis NB, Srinivasan S, Bhattacharya R, Wise MS, Frost JD, Jr., Mizrahi EM. Extraction of motion strength and motor activity signals from video recordings of neonatal seizures. IEEE Trans Med Imaging 2001;20:965-80.
• Ramabhadran B, Frost JD, Jr., Glover JR, Ktonas PY. An automated system for epileptogenic focus localization in the electroencephalogram. J Clin Neurophysiol 1999;16:59-68.
• Glaze DG, Schultz RJ, Frost JD. Rett syndrome: characterization of seizures versus non-seizures. Electroencephalogr Clin Neurophysiol 1998;106:79-83.
• Chatrian GE, Bergamasco B, Bricolo A, Frost JD, Jr., Prior PF. IFCN recommended standards for electrophysiologic monitoring in comatose and other unresponsive states. Report of an IFCN committee. Electroencephalogr Clin Neurophysiol 1996;99:103-22.
• Frost JD, Jr., Hrachovy RA, Glaze DG, Rettig GM. Alpha rhythm slowing during initiation of carbamazepine therapy: implications for future cognitive performance. J Clin Neurophysiol 1995;12:57-63.
• Lee CL, Hrachovy RA, Smith KL, Frost JD, Jr., Swann JW. Tetanus toxin-induced seizures in infant rats and their effects on hippocampal excitability in adulthood. Brain Res 1995;677:97-109.
• Hrachovy RA, Frost JD, Jr., Glaze DG. High-dose, long-duration versus low-dose, short-duration corticotropin therapy for infantile spasms. J Pediatr 1994;124:803-6.
• Hrachovy RA, Frost JD, Jr., Glaze DG. Coupling of focal electrical seizure discharges with infantile spasms: incidence during long-term monitoring in newly diagnosed patients. J Clin Neurophysiol 1994;11:461-4.
• Percy AK, Glaze DG, Schultz RJ, Zoghbi HY, Williamson D, Frost JD, Jr., Jankovic JJ, del Junco D, Skender M, Waring S, et al.. Rett syndrome: controlled study of an oral opiate antagonist, naltrexone. Ann Neurol 1994;35:464-70.
• Butte NF, Jensen CL, Moon JK, Glaze DG, Frost JD, Jr.. Sleep organization and energy expenditure of breast-fed and formula-fed infants. Pediatr Res 1992;32:514-9.
• Frost JD, Jr., Hrachovy RA, Glaze DG. Spike morphology in childhood focal epilepsy: relationship to syndromic classification. Epilepsia 1992;33:531-6.
• Frost JD, Jr., Hrachovy RA, Glaze DG, McCully MI. Sleep modulation of interictal spike configuration in untreated children with partial seizures. Epilepsia 1991;32:341-6.
• Hrachovy RA, Frost JD, Jr., Glaze DG, Kellaway P. Surgical treatment for infantile spasms?. Ann Neurol 1991;29:110-2.
• Hrachovy RA, Glaze DG, Frost JD, Jr.. A retrospective study of spontaneous remission and long-term outcome in patients with infantile spasms. Epilepsia 1991;32:212-4.
• Glover JR, Jr., Raghavan N, Ktonas PY, Frost JD, Jr.. Context-based automated detection of epileptogenic sharp transients in the EEG: elimination of false positives. IEEE Trans Biomed Eng 1989;36:519-27.
• Hrachovy RA, Frost JD, Jr.. Infantile spasms. Cleve Clin J Med 1989;:S10-6; dicussion S40-2.
• Hrachovy RA, Frost JD, Jr.. Infantile spasms. Pediatr Clin North Am 1989;36:311-29.
• Hrachovy RA, Frost JD, Jr., Glaze DG, Rose D. Treatment of infantile spasms with methysergide and alpha-methylparatyrosine. Epilepsia 1989;30:607-10.
• Frost JD, Jr., Glaze DG, Rosen CL. Munchausen's syndrome by proxy and video surveillance. Am J Dis Child 1988;142:917-8.
• Glaze DG, Hrachovy RA, Frost JD, Jr., Kellaway P, Zion TE. Prospective study of outcome of infants with infantile spasms treated during controlled studies of ACTH and prednisone. J Pediatr 1988;112:389-96.
• Hrachovy RA, Frost JD, Jr., Glaze DG. Treatment of infantile spasms with tetrabenazine. Epilepsia 1988;29:561-3.
• Hrachovy RA, Frost JD, Jr., Pollack MS, Glaze DG. Serologic HLA typing in infantile spasms. Epilepsia 1988;29:817-9.
• Veregge S, Frost JD, Jr.. Relationship between single-unit activity and the electroencephalogram in a neocortical, cobalt-induced epileptogenic focus. Electroencephalogr Clin Neurophysiol 1988;69:34-44.
• Frost JD, Jr.. Data reduction methods for intensive neurodiagnostic monitoring: future directions for development. Adv Neurol 1987;46:271-9.
• Glaze DG, Frost JD, Jr., Zoghbi HY, Percy AK. Rett's syndrome: characterization of respiratory patterns and sleep. Ann Neurol 1987;21:377-82.
• Glaze DG, Frost JD, Jr., Zoghbi HY, Percy AK. Rett's syndrome. Correlation of electroencephalographic characteristics with clinical staging. Arch Neurol 1987;44:1053-6.
• Hrachovy RA, Frost JD, Jr., Gospe SM, Jr., Glaze DG. Infantile spasms following near-drowning: a report of two cases. Epilepsia 1987;28:45-8.
• Jerger J, Chmiel R, Glaze D, Frost JD, Jr.. Rate and filter dependence of the middle-latency response in infants. Audiology 1987;26:269-83.
• Frost JD, Jr., Kellaway P, Hrachovy RA, Glaze DG, Mizrahi EM. Changes in epileptic spike configuration associated with attainment of seizure control. Ann Neurol 1986;20:723-6.
• Glaze DG, Hrachovy RA, Frost JD, Jr., Zion TE, Bryan RN. Computed tomography in infantile spasms: effects of hormonal therapy. Pediatr Neurol 1986;2:23-7.
• Jerger J, Chmiel R, Frost JD, Jr., Coker N. Effect of sleep on the auditory steady state evoked potential. Ear Hear 1986;7:240-5.
• McGuire DA, Frost JD, Floerchinger SL. Local anesthesia and arthroscopic surgery of the knee. Alaska Med 1986;28:20-4.
• Rosen CL, Frost JD, Jr., Glaze DG. Child abuse and recurrent infant apnea. J Pediatr 1986;109:1065-7.
• Rosen CL, Glaze DG, Frost JD, Jr.. Home monitor follow-up of persistent apnea and bradycardia in preterm infants. Am J Dis Child 1986;140:547-50.
• Frost JD, Jr.. Automatic recognition and characterization of epileptiform discharges in the human EEG. J Clin Neurophysiol 1985;2:231-49.
• Kellaway P, Frost JD, Jr.. Monitoring at the Baylor College of Medicine, Houston. Electroencephalogr Clin Neurophysiol Suppl 1985;37:403-14.
• Veregge S, Frost JD, Jr.. A simple inexpensive, hydraulic microdrive for recording neocortical unit activity in the unanesthetized rat. Electroencephalogr Clin Neurophysiol 1985;61:94-7.
• Hrachovy RA, Frost JD, Jr., Glaze DG. What have we learned about sudden infant death?. N Engl J Med 1984;310:787-8.
• Hrachovy RA, Frost JD, Jr., Kellaway P. Hypsarrhythmia: variations on the theme. Epilepsia 1984;25:317-25.
• Jankovic J, Glaze DG, Frost JD, Jr.. Effect of tetrabenazine on tics and sleep of Gilles de la Tourette's syndrome. Neurology 1984;34:688-92.
• Rosen CL, Glaze DG, Frost JD, Jr.. Hypoxemia associated with feeding in the preterm infant and full-term neonate. Am J Dis Child 1984;138:623-8.
• Glaze DG, Frost JD, Jr., Jankovic J. Sleep in Gilles de la Tourette's syndrome: disorder of arousal. Neurology 1983;33:586-92.
• Hrachovy RA, Frost JD, Jr., Kellaway P, Zion TE. Double-blind study of ACTH vs prednisone therapy in infantile spasms. J Pediatr 1983;103:641-5.
• Mizrahi EM, Maulsby RL, Frost JD, Jr.. Improved wave V resolution by dual-channel brain stem auditory evoked potential recording. Electroencephalogr Clin Neurophysiol 1983;55:105-7.
• Rosen CL, Frost JD, Jr., Bricker T, Tarnow JD, Gillette PC, Dunlavy S. Two siblings with recurrent cardiorespiratory arrest: Munchausen syndrome by proxy or child abuse?. Pediatrics 1983;71:715-20.
• Rosen CL, Frost JD, Jr., Harrison GM. Infant apnea: polygraphic studies and follow-up monitoring. Pediatrics 1983;71:731-6.
• McGuire DA, Brudenell R, Frost JD, Newman MH. Arthroscopy: a perspective. Alaska Med 1982;24:46-50.
• Hrachovy RA, Frost JD, Jr., Kellaway P. Sleep characteristics in infantile spasms. Neurology 1981;31:688-93.
• Jankovic J, Frost JD, Jr.. Quantitative assessment of parkinsonian and essential tremor: clinical application of triaxial accelerometry. Neurology 1981;31:1235-40.
• Saltzberg B, Kellaway P, Burton WD, Jr., Frost JD, Jr.. Epilepsy: a heuristic model for relating nocturnal sleep EEG spike distributions to the risk of seizure. Int J Biomed Comput 1981;12:16-Sep.
• Frost JD, Jr., Hillman CE, Jr., Kellaway P. Automatic interpretation of EEG: analysis of background activity. Comput Biomed Res 1980;13:242-57.
• Hrachovy RA, Frost JD, Jr., Kellaway P, Zion T. A controlled study of ACTH therapy in infantile spasms. Epilepsia 1980;21:631-6.
• Kellaway P, Frost JD, Jr., Crawley JW. Time modulation of spike-and-wave activity in generalized epilepsy. Ann Neurol 1980;8:491-500.
• Frost JD, Jr.. Microprocessor-based EEG spike detection and quantification. Int J Biomed Comput 1979;10:357-73.
• Frost JD, Jr., DeLucchi MR. Insomnia in the elderly: treatment with flurazepam hydrochloride. J Am Geriatr Soc 1979;27:541-6.
• Hrachovy RA, Frost JD, Jr., Kellaway P, Zion T. A controlled study of prednisone therapy in infantile spasms. Epilepsia 1979;20:403-7.
• Kellaway P, Frost JD, Jr., Crawley JW. Time modulation of ictal and interictal spike-and-wave activity in generalized epilepsy. Trans Am Neurol Assoc 1979;104:92-3.
• Kellaway P, Hrachovy RA, Frost JD, Jr., Zion T. Precise characterization and quantification of infantile spasms. Ann Neurol 1979;6:214-8.
• Frost JD, Jr.. Triaxial vector accelerometry: a method for quantifying tremor and ataxia. IEEE Trans Biomed Eng 1978;25:17-27.
• Frost JD, Jr., Hrachovy RA, Kellaway P, Zion T. Quantitative analysis and characterization of infantile spasms. Epilepsia 1978;19:273-82.
• Carrie JR, Frost JD, Jr.. Clinical evaluation of a method of quantification of generalized spike-wave EEG patterns by computer during prolonged recordings. Comput Biomed Res 1977;10:449-57.
• Fann WE, Stafford JR, Malone RL, Frost JD, Jr., Richman BW. Clinical research techniques in tardive dyskinesia. Am J Psychiatry 1977;134:759-62.
• Frost JD, Jr., Shumate WH, Salamy JG, Booher CR. Sleep monitoring: the second manned Skylab mission. Aviat Space Environ Med 1976;47:372-82.
• Frost JD, Jr., Shumate WH, Booher CR, DeLucchi MR. The Skylab sleep monitoring experiment: methodology and initial results. Acta Astronaut 1975;2:319-36.
• Frost JD, Jr., Carrie JR, Borda RP, Kellaway P. The effects of dalmane (flurazepam hydrochloride) on human EEG characteristics. Electroencephalogr Clin Neurophysiol 1973;34:171-5.
• Hutton JT, Frost JD, Jr., Foster J. the influence of the cerebellum in cat penicillin epilepsy. Epilepsia 1972;13:401-8.
• Carrier JR, Frost JD, Jr.. A small computer system for EEG wavelength-amplitude profile analysis. Int J Biomed Comput 1971;2:251-63.
• Frost JD, Jr.. An automatic sleep analyzer. Electroencephalogr Clin Neurophysiol 1970;29:88-92.
• Frost JD. Wave length analysis of the EEG--the alpha profile. Electroencephalogr Clin Neurophysiol 1969;27:702-3.
• Frost JD, Jr.. Statistical analysis of EEG-single neuron relationships. Electroencephalogr Clin Neurophysiol 1969;27:550-1.
• Borda RP, Frost JD, Jr.. Error reduction in small sample averaging through the use of the median rather than the mean. Electroencephalogr Clin Neurophysiol 1968;25:391-2.
• Frost JD, Jr.. EEG-intracellular potential relationships in isolated cerebral cortex. Electroencephalogr Clin Neurophysiol 1968;24:434-43.
• Frost JD, Jr., Elazar Z. Three-dimensional selective amplitude histograms: a statistical approach to EEG-single neuron relationships. Electroencephalogr Clin Neurophysiol 1968;25:499-503.
• Low MD, Frost JD, Jr., Maulsby RL, McSherry W. Electroencephalographic correlates of preparation set. Electroencephalogr Clin Neurophysiol 1968;24:286.
• Frost JD, Jr.. Comparison of intracellular potentials and ECoG activity in isolated cerebral cortex. Electroencephalogr Clin Neurophysiol 1967;23:89-90.
• Frost JD, Jr.. An averaging technique for detection of EEG-intracellular potential relationships. Electroencephalogr Clin Neurophysiol 1967;23:179-81.
• Frost JD, Jr., Low MD. An electronic method for determining time-locked changes in neuronal firing rate. Electroencephalogr Clin Neurophysiol 1967;23:176-8.
• Proler ML, Frost JD, Jr., Maulsby RL, Crawley JW. Electroencephalography. Prog Neurol Psychiatry 1967;22:260-94.
• Frost JD, Jr., Gol A. Computer determination of relationships between EEG activity and single unit discharges in isolated cerebral cortex. Exp Neurol 1966;14:506-19.
• Frost JD, Jr., Kellaway P, Gol A. Single-unit discharges in isolated cerebral cortex. Exp Neurol 1966;14:305-16.
• Maulsby RL, Frost JD, Jr., Graham MH. A simple electronic method for graphing EEG sleep patterns. Electroencephalogr Clin Neurophysiol 1966;21:501-3.
• Proler ML, Frost JD, Jr., Maulsby RL, Crawley JW. Electroencephalography. Prog Neurol Psychiatry 1966;21:330-57.
• Proler ML, Frost JD, Jr., Maulsby RL, Crawley JW. Electroencephalography. Prog Neurol Psychiatry 1965;20:439-54.
• Winter DL, Frost JD, Jr.. Recovery Cycles in the Lemniscal System. Electroencephalogr Clin Neurophysiol 1964;16:459-69.

Contact Information

James D. Frost, Jr., M.D.
Department of Neurology
Baylor College of Medicine
One Baylor Plaza, MS NB302
Houston, Texas 77030

Tel: 713-798-0980
Fax: 713-798-0984
Email:

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