Daniel L. Burgess, Ph.D.
Assistant Professor of Neurology
Graduate School
Ph.D. (l996) University of Michigan
Clinical Interests
Epilepsy, neurogenetic disorders, ion channelopathies, translational genomics.
Research Interests
Analysis of inherited neurological disorders in humans and animal models provides a unique window on the development and function of the mammalian nervous system. I am interested in the evolutionary influences, general biological principles, and specific mechanisms that allow one complex system (the mammalian genome) to regulate the development and day-to-day functions of another complex system (the mammalian brain). Research is currently focused on ion channel mutations in humans and mouse models with epilepsy and ataxia, the relationship of subunit combinatorial complexity to the function of ion channels, and mechanisms that (dys)regulate gene expression in the epileptic brain. Experimental techniques include classical and molecular genetics, transgenics, tissue culture, electrophysiology, in situ hybridization and immunohistochemistry.
Publications
- Deng F, Price MG, Davis CF, Mori M, Burgess DL. Stargazin and other transmembrane AMPA receptor regulating proteins interact with synaptic scaffolding protein MAGI-2 in brain. J Neurosci 2006;26:7875-84.
- Burgess DL. Neonatal epilepsy syndromes and GEFS+: mechanistic considerations. Epilepsia 2005;:51-8. "
- Price MG, Davis CF, Deng F, Burgess DL. The alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate receptor trafficking regulator ""stargazin"" is related to the claudin family of proteins by Its ability to mediate cell-cell adhesion. J Biol Chem 2005;280:19711-20. "
- Mori M, Burgess DL, Gefrides LA, Foreman PJ, Opferman JT, Korsmeyer SJ, Cavalheiro EA, Naffah-Mazzacoratti MG, Noebels JL. Expression of apoptosis inhibitor protein Mcl1 linked to neuroprotection in CNS neurons. Cell Death Differ 2004;11:1223-33.
- Zhang Y, Mori M, Burgess DL, Noebels JL. Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons. J Neurosci 2002;22:6362-71.
- Burgess DL. Listen carefully: positional cloning of an audiogenic seizure mutation may yield Frings benefits. Neuron 2001;31:507-8.
- Burgess DL, Gefrides LA, Foreman PJ, Noebels JL. A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family. Genomics 2001;71:339-50.
- Heilstedt HA, Burgess DL, Anderson AE, Chedrawi A, Tharp B, Lee O, Kashork CD, Starkey DE, Wu YQ, Noebels JL, Shaffer LG, Shapira SK. Loss of the potassium channel beta-subunit gene, KCNAB2, is associated with epilepsy in patients with 1p36 deletion syndrome. Epilepsia 2001;42:1103-11.
- Burgess DL, Jones JM, Meisler MH, Noebels JL. Mutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse. Cell 1997;88:385-92.
Contact Information
Daniel L. Burgess, Ph.D.
Department of Neurology
Baylor College of Medicine
One Baylor Plaza, MS NB302
Houston, Texas 77030
Tel: 713-798-5862
Fax: 713-798-7528
Email: